Protein Alignment CG18478 and PLAU

DIOPT Version :10

• Sequence 1: NP_609764.1
• Gene: CG18478 / 34923
• FlyBaseID: FBgn0028517
• Length: 294
• Species: Drosophila melanogaster
• Sequence 2: NP_002649.2
• Gene: PLAU / 5328
• HGNCID: 9052
• Length: 431
• Species: Homo sapiens
• Alignment Length: 279
• Identity: 87/279 - (31%)
• Similarity: 126/279 - (45%)
• Gaps: 34/279 - (12%)

  Fly    27 EELK--CGYGNPDAVKVQFNVTEGQAKPAE-FPWTIAVIHNR------SLVGGGSLITPDIVLTA 82
            ||||  ||   ...::.:|.:..|:....| .|| .|.|:.|      :.|.|||||:|..|::|
Human   162 EELKFQCG---QKTLRPRFKIIGGEFTTIENQPW-FAAIYRRHRGGSVTYVCGGSLISPCWVISA 222

  Fly    83 AHRIFN-KDVEDIVVSAGEWEYGSALE-KYPFEEAFVLKMVIHKSFNYQRGA--NNLALLFL--- 140
            .|...: ...||.:|..|.....|..: :..||   |..:::||.::....|  |::|||.:
Human   223 THCFIDYPKKEDYIVYLGRSRLNSNTQGEMKFE---VENLILHKDYSADTLAHHNDIALLKIRSK 284

  Fly   141 -DREFPLTYKINTICLPTQKRSLS-STRCIVAGWGKYQFSDTHYGGVLKKIDLPIVPRHICQDQL 203
             .|....:..|.|||||:...... .|.|.:.|:||...:|..|...||...:.::....||
Human   285 EGRCAQPSRTIQTICLPSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQ--- 346

  Fly   204 RKTRLGQNYTLPRGLICAGGEK-DNDACTGDGGGALFCPMTEDPKQFEQIGIVNWGVGCKEKNVP 267
            :....|...|..  ::||...: ..|:|.||.||.|.|.:   ..:....|||:||.||..|:.|
Human   347 QPHYYGSEVTTK--MLCAADPQWKTDSCQGDSGGPLVCSL---QGRMTLTGIVSWGRGCALKDKP 406

  Fly   268 ATYTDVFEFKPWIVQQIKE 286
            ..||.|..|.|||....||
Human   407 GVYTRVSHFLPWIRSHTKE 425

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG18478	NP_609764.1	Tryp_SPc	50..280	CDD:214473	75/246 (30%)
PLAU	NP_002649.2	Binds urokinase plasminogen activator surface receptor. /evidence=ECO:0000250	34..57
		KR	67..152	CDD:238056
		Connecting peptide	152..177		6/17 (35%)
		Tryp_SPc	179..422	CDD:238113	78/254 (31%)