DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nht and TAF4B

DIOPT Version :9

Sequence 1:	NP_523574.4	Gene:	nht / 34902	FlyBaseID:	FBgn0041103	Length:	245	Species:	Drosophila melanogaster
Sequence 2:	NP_001280654.1	Gene:	TAF4B / 6875	HGNCID:	11538	Length:	867	Species:	Homo sapiens

Alignment Length:	220	Identity:	53/220 - (24%)
Similarity:	98/220 - (44%)	Gaps:	46/220 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 SIYKKIM----KHLSQGNQADDINISEQEWLLDSFLAALETYMKHVVKKTIELCEHR-TSYHLHN 112
            ::.|:|:    ||......:|.:|:..|         |.:..::.:::|...:.:|| |:|..
Human   664 ALQKRILDIGKKHDITELNSDAVNLISQ---------ATQERLRGLLEKLTAIAQHRMTTYKA-- 717

  Fly   113 DERCVMKNDMRVTMMFL----------NDLEIADY--------GSSDDETGFYRKRRAENIDEER 159
            .|..::.:|.|..:.||          .|||..:.        .:.:|......|::|:.: ::.
Human   718 SENYILCSDTRSQLKFLEKLDQLEKQRKDLEEREMLLKAAKSRSNKEDPEQLRLKQKAKEL-QQL 781

  Fly   160 KVARLE--SVNDTALLAISGR-KRPGEQ----LAPESAPSGSKVAKLTGAPIQRACAPRFKHMNI 217
            ::|:::  ..|.|||.||..| |||.|.    |......||:  :.||..  ::...||...:.:
Human   782 ELAQIQHRDANLTALAAIGPRKKRPLESGIEGLKDNLLASGT--SSLTAT--KQLHRPRITRICL 842

  Fly   218 RDVLQFMEEDRRYARSNMLFEAYLK 242
            ||::..||::|....|..|:.|.||
Human   843 RDLIFCMEQEREMKYSRALYLALLK 867

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nht	NP_523574.4	TAF4	10..238	CDD:173965	50/214 (23%)
TAF4B	NP_001280654.1	Sufficient for interaction with ZNF628. /evidence=ECO:0000250\|UniProtKB:G5E8Z2	100..241
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	219..239
		TAFH	258..346	CDD:284862
		TAF4	621..862	CDD:283017	49/213 (23%)
		Required for interaction with TAF12. /evidence=ECO:0000269\|PubMed:15601843	835..867		10/31 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2341
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001841
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR15138
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.000