Protein Alignment nht and TAF4B

DIOPT Version :10

• Sequence 1: NP_523574.4
• Gene: nht / 34902
• FlyBaseID: FBgn0041103
• Length: 245
• Species: Drosophila melanogaster
• Sequence 2: NP_001280654.1
• Gene: TAF4B / 6875
• HGNCID: 11538
• Length: 867
• Species: Homo sapiens
• Alignment Length: 220
• Identity: 53/220 - (24%)
• Similarity: 98/220 - (44%)
• Gaps: 46/220 - (20%)

  Fly    53 SIYKKIM----KHLSQGNQADDINISEQEWLLDSFLAALETYMKHVVKKTIELCEHR-TSYHLHN 112
            ::.|:|:    ||......:|.:|:..|         |.:..::.:::|...:.:|| |:|..
Human   664 ALQKRILDIGKKHDITELNSDAVNLISQ---------ATQERLRGLLEKLTAIAQHRMTTYKA-- 717

  Fly   113 DERCVMKNDMRVTMMFL----------NDLEIADY--------GSSDDETGFYRKRRAENIDEER 159
            .|..::.:|.|..:.||          .|||..:.        .:.:|......|::|:.: ::.
Human   718 SENYILCSDTRSQLKFLEKLDQLEKQRKDLEEREMLLKAAKSRSNKEDPEQLRLKQKAKEL-QQL 781

  Fly   160 KVARLE--SVNDTALLAISGR-KRPGEQ----LAPESAPSGSKVAKLTGAPIQRACAPRFKHMNI 217
            ::|:::  ..|.|||.||..| |||.|.    |......||:  :.||..  ::...||...:.:
Human   782 ELAQIQHRDANLTALAAIGPRKKRPLESGIEGLKDNLLASGT--SSLTAT--KQLHRPRITRICL 842

  Fly   218 RDVLQFMEEDRRYARSNMLFEAYLK 242
            ||::..||::|....|..|:.|.||
Human   843 RDLIFCMEQEREMKYSRALYLALLK 867

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nht	NP_523574.4	TAF4	<85..237	CDD:461598	42/177 (24%)
TAF4B	NP_001280654.1	PHA03247	<14..154	CDD:223021
		Sufficient for interaction with ZNF628. /evidence=ECO:0000250|UniProtKB:G5E8Z2	100..241
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	219..239
		TAFH	258..349	CDD:462195
		TAF4	621..862	CDD:461598	49/213 (23%)
		Required for interaction with TAF12. /evidence=ECO:0000269|PubMed:15601843	835..867		10/31 (32%)