DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15262 and CNOT2

DIOPT Version :9

Sequence 1:	NP_609750.1	Gene:	CG15262 / 34901	FlyBaseID:	FBgn0028852	Length:	438	Species:	Drosophila melanogaster
Sequence 2:	NP_001186231.1	Gene:	CNOT2 / 4848	HGNCID:	7878	Length:	540	Species:	Homo sapiens

Alignment Length:	449	Identity:	99/449 - (22%)
Similarity:	164/449 - (36%)	Gaps:	174/449 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 DQQEVESSPSPPPPPPFQSPLSSPESLQTPDGYPILYVDVVKNKPKQELPPSASPSQPLAPEFSI 75
            |:...|.|.:|       :||.:|.:.:.|      ||.:|           ..|:...:.:|||
Human   235 DRNRREGSGNP-------TPLINPLAGRAP------YVGMV-----------TKPANEQSQDFSI 275

  Fly    76 FREDFPALPGS-----------LPSALPTALPTTSS---PVVPDDWTAMMSNSEQVELAKFRNTV 126
            ..|||||||||           ..|.|.|:..||||   |..|.|.::...|:.|
Human   276 HNEDFPALPGSSYKDPTSSNDDSKSNLNTSGKTTSSTDGPKFPGDKSSTTQNNNQ---------- 330

  Fly   127 IRNSSDPCVNANGNEVLRQPTHAPEKRQNMELLPHMYGYLGNPFRLNLSMIFTKQFLLEGVRQRA 191
                                     :::.:::||                        :|
Human   331 -------------------------QKKGIQVLP------------------------DG----- 341

  Fly   192 INAAHKRAALAKPAIQPPPGFENCKIFARLITNSDGMPLGGVTFELGSPTNETTSNVEAKPSGST 256
                                         .:||   :|.|.||.:
Human   342 -----------------------------RVTN---IPQGMVTDQ-------------------- 354

  Fly   257 IQGAFGMLGLAKKLRSINQNP----LLFGNNVAHNIG---GAADSI---FTGPIQEARLTPQEMS 311
                |||:||...:|:...:|    |..|:::. .:|   .:.:::   |..|...:...||::.
Human   355 ----FGMIGLLTFIRAAETDPGMVHLALGSDLT-TLGLNLNSPENLYPKFASPWASSPCRPQDID 414

  Fly   312 YKLPLNYLFNVNM--SLQEPKIEEMHDELLFFFFYTYAGDMMQMLAAAELAERGWRYHKYEHFWV 374
            :.:|..||.|:::  .|...|:....::|||:.:|...||::|:|||.||..|.|||||.|..|:
Human   415 FHVPSEYLTNIHIRDKLAAIKLGRYGEDLLFYLYYMNGGDVLQLLAAVELFNRDWRYHKEERVWI 479

  Fly   375 IRQADNPNYLYHGFREFGEYNYFNMWQWKILPRHFYLDPEILERTLSKEELYVTYGYHP 433
            .|.......:.....|.|.|.:|:...|:.:.:.|:|:.:.||   .:..|..|:.|:|
Human   480 TRAPGMEPTMKTNTYERGTYYFFDCLNWRKVAKEFHLEYDKLE---ERPHLPSTFNYNP 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15262	NP_609750.1	NOT2_3_5	294..414	CDD:282064	38/124 (31%)
CNOT2	NP_001186231.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	96..126
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	276..342		24/158 (15%)
		NOT2_3_5	396..519	CDD:398019	38/122 (31%)
		Repressor domain	437..540		34/102 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151431
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5601
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2523
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1273874at2759
OrthoFinder	1	1.000	-	-		FOG0003536
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23326
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2209
SonicParanoid	1	1.000	-	-		X2412
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.790