DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG4168 and 18w

DIOPT Version :10

Sequence 1:NP_609740.4 Gene:CG4168 / 34889 FlyBaseID:FBgn0028888 Length:1330 Species:Drosophila melanogaster
Sequence 2:NP_476814.1 Gene:18w / 37277 FlyBaseID:FBgn0287775 Length:1385 Species:Drosophila melanogaster


Alignment Length:1113 Identity:282/1113 - (25%)
Similarity:442/1113 - (39%) Gaps:296/1113 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   341 RLDLGQNCIENLESDYFQQNYSDVHLRALNLEQNFVTQLPEAVFKATGIAHLVLAFNAISRVHPS 405
            ||||  .|.:.|             |.|..|......||.:       ::.|.:....:.||.|:
  Fly    66 RLDL--QCSQEL-------------LHASELAPGLFRQLQK-------LSELRIDACKLQRVPPN 108

  Fly   406 AFEGLTETLEYLDLERNRLTTVPVALSSLHHLKYLYLTSNQISQLNNLPSFTENLRVLSLSGNNF 470
            |||||. :|:.|.||.:.....|.                               :.|.|.|.:|
  Fly   109 AFEGLM-SLKRLTLESHNAVWGPG-------------------------------KTLELHGQSF 141

  Fly   471 SMIPVLGLKNYTQLSYLNMGYNSITDIPEGIFAVDSWGS--NLQTILLRNNKITHLHL------- 526
            .     |||   :||.|::|.|:|..:|||:     |.|  :||.:.|..|:|.....       
  Fly   142 Q-----GLK---ELSELHLGDNNIRQLPEGV-----WCSMPSLQLLNLTQNRIRSAEFLGFSEKL 193

  Fly   527 ----------GSFAGLEQIQEISLSFNDITIHHPLVFENVSRTLKILELSFAVFPARSLESLDPL 581
                      |:.:|..::|.:.:|||::.........:..|.|:.|.|..     .::.:|.| 
  Fly   194 CAGSALSNANGAVSGGSELQTLDVSFNELRSLPDAWGASRLRRLQTLSLQH-----NNISTLAP- 252

  Fly   582 DALLPLSQLIWLGLDNNNLKQVSNESFAQMRELSYINLSFNQLKTLPRGLFQSDAH--SHLVEID 644
            :||..||.|..|.:..|:|..:.:|:||..:||..::|..|.|..||:||.    |  ..|:.:|
  Fly   253 NALAGLSSLRVLNISYNHLVSLPSEAFAGNKELRELHLQGNDLYELPKGLL----HRLEQLLVLD 313

  Fly   645 LSYNGL--ERLEAQTFHSLGDLQTLNLQSNRLRTIARHAFHNLEFLRYLDLSYNRLVNISHGAFT 707
            ||.|.|  ..::..||..|..|..|||.:|.|..|....|..|.||:.||:..|.:.:|..|||.
  Fly   314 LSGNQLTSHHVDNSTFAGLIRLIVLNLSNNALTRIGSKTFKELYFLQILDMRNNSIGHIEEGAFL 378

  Fly   708 VLPNLAALDLMHNQLCSLSLKSF--LYVSNTTTPLRLNVSHNHIASFYDELSSYMYIYQLDISHN 770
            .|.||..|:|..|:|.:|..:.|  |||   .|.|.||   |::.|                   
  Fly   379 PLYNLHTLNLAENRLHTLDNRIFNGLYV---LTKLTLN---NNLVS------------------- 418

  Fly   771 HVTKSDSFTNLANTLRFLNLAHNQLGSLQSHAFGDLEFLEILNVAHNNLTSLRRRSFQGLNSLQE 835
             :.:|.:|.|.:: |:.|:|:.|||..: ..|..||..|:.|::..|.::..:..:|:.||.|..
  Fly   419 -IVESQAFRNCSD-LKELDLSSNQLTEV-PEAVQDLSMLKTLDLGENQISEFKNNTFRNLNQLTG 480

  Fly   836 LDLSHNQLDQLQVEQFSNLRKLRILRINSNRLRALPREVF-MNTRLEFLDIAENQLSVWPVPAFT 899
            |.|..|::..:.|..|.:|.:|.:|.:..||::::.|..| .||.:|.:.:.:|.|        |
  Fly   481 LRLIDNRIGNITVGMFQDLPRLSVLNLAKNRIQSIERGAFDKNTEIEAIRLDKNFL--------T 537

  Fly   900 DIG---FTLRS---IQMSHNNLEYLDASMFINSQFLY------------------------DISL 934
            ||.   .||.|   :.:|.|:|.:.|.: ||.|...:                        .:..
  Fly   538 DINGIFATLASLLWLNLSENHLVWFDYA-FIPSNLKWLDIHGNYIEALGNYYKLQEEIRVTTLDA 601

  Fly   935 ARNRIT-----ILPDN-TFSFLNNLTNLDLSQNPLV-TTNLREVFVHTPRLRKLSLHHMGLYVLP 992
            :.||||     .:|:: ...|:||.....:..|..| .|.|..|.::...|.|:||:  .|.|.|
  Fly   602 SHNRITEIGAMSVPNSIELLFINNNIIGQIQANTFVDKTRLARVDLYANVLSKISLN--ALRVAP 664

  Fly   993 -PLKLPLLSY--------LDVSGNYLQELSPLGSLRHLRHVNVSHNKLTNASCAAEHLPPSVRVL 1048
             ..:.|:..:        .|.|..:||.::.|.:.:|...|:     |.|..|...|        
  Fly   665 VSAEKPVPEFYLGGNPFECDCSMEWLQRINNLTTRQHPHVVD-----LGNIECLMPH-------- 716

  Fly  1049 DLAHNPLRRITLHDLASLR----------------HLAELNILDVKVTNP---QAFSKLRSLRKL 1094
                  .|...|..||||.                |..|....:.:|..|   ..|........:
  Fly   717 ------SRSAPLRPLASLSASDFVCKYESHCPPTCHCCEYEQCECEVICPGNCSCFHDATWATNI 775

  Fly  1095 HASSHANLGEIVARIPGLQQLRVHCLEPNIGQQL-FAKLANNTKIRLLELYGSNVQTIAPDVFTG 1158
            ......:|..:..|||  |.:....|:.|...:| ...|.....:|.|.|..||:.|:...    
  Fly   776 VDCGRQDLAALPNRIP--QDVSDLYLDGNNMPELEVGHLTGRRNLRALYLNASNLMTLQNG---- 834

  Fly  1159 LSRSQRLQVKISH---TRISDLPPGIFYA---LREV----------------PHLSIDI---SHN 1198
             |.:|.:.:::.|   .:::.|....|.:   |||:                |.:|:::   .:|
  Fly   835 -SLAQLVNLRVLHLENNKLTALEGTEFRSLGLLRELYLHNNMLTHISNATFEPLVSLEVLRLDNN 898

  Fly  1199 RINALAADSFYPNKSYWDAVGTRSIMGGLITSHNPLECECGLVWFGHWLRRWLRESAQIKVIQKD 1263
            |:::|      |:..|      |..:.||....|...|.|          :.|||.||.    ..
  Fly   899 RLSSL------PHLQY------RHSLQGLTLGRNAWSCRC----------QQLRELAQF----VS 937

  Fly  1264 DLKRMVQRARANTCHDPTSGRHLPI---LEIFPE--DLL-CQASALSSS-----GQRIFLLSFAM 1317
            |...:|:.|....|.|....|.|.:   |...|:  ||| ..||.:|||     |.|:.||:..:
  Fly   938 DNAMVVRDAHDIYCLDAGIKRELELIGNLANGPDCSDLLDASASNISSSQDLAGGYRLPLLAAVL 1002

  Fly  1318 ALLIPIVM 1325
            .|:..:|:
  Fly  1003 VLIFLVVV 1010

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG4168NP_609740.4 PRK15370 <69..>353 CDD:185268 5/11 (45%)
leucine-rich repeat 99..118 CDD:275380
leucine-rich repeat 122..146 CDD:275380
leucine-rich repeat 147..170 CDD:275380
leucine-rich repeat 171..194 CDD:275380
leucine-rich repeat 195..214 CDD:275380
leucine-rich repeat 215..236 CDD:275380
leucine-rich repeat 266..287 CDD:275380
leucine-rich repeat 288..311 CDD:275380
leucine-rich repeat 312..338 CDD:275380
LRR <338..651 CDD:443914 87/332 (26%)
leucine-rich repeat 339..365 CDD:275380 6/23 (26%)
leucine-rich repeat 366..388 CDD:275380 5/21 (24%)
leucine-rich repeat 389..412 CDD:275380 9/22 (41%)
leucine-rich repeat 414..436 CDD:275380 5/21 (24%)
leucine-rich repeat 437..459 CDD:275380 0/21 (0%)
leucine-rich repeat 460..483 CDD:275380 7/22 (32%)
leucine-rich repeat 484..510 CDD:275380 11/27 (41%)
leucine-rich repeat 511..534 CDD:275380 7/39 (18%)
leucine-rich repeat 535..589 CDD:275380 13/53 (25%)
LRR 543..971 CDD:443914 134/471 (28%)
leucine-rich repeat 590..613 CDD:275380 7/22 (32%)
leucine-rich repeat 614..639 CDD:275380 9/26 (35%)
leucine-rich repeat 640..663 CDD:275380 9/24 (38%)
leucine-rich repeat 664..687 CDD:275380 9/22 (41%)
leucine-rich repeat 688..711 CDD:275380 9/22 (41%)
leucine-rich repeat 712..735 CDD:275380 10/24 (42%)
leucine-rich repeat 740..783 CDD:275380 8/42 (19%)
leucine-rich repeat 785..808 CDD:275380 9/22 (41%)
leucine-rich repeat 809..832 CDD:275380 5/22 (23%)
leucine-rich repeat 833..856 CDD:275380 7/22 (32%)
leucine-rich repeat 857..879 CDD:275380 7/22 (32%)
leucine-rich repeat 880..900 CDD:275380 3/19 (16%)
leucine-rich repeat 905..928 CDD:275380 9/25 (36%)
LRR 911..>1203 CDD:443914 77/376 (20%)
leucine-rich repeat 929..952 CDD:275380 6/52 (12%)
leucine-rich repeat 953..977 CDD:275380 5/24 (21%)
leucine-rich repeat 978..1020 CDD:275380 13/50 (26%)
leucine-rich repeat 1045..1068 CDD:275380 6/38 (16%)
leucine-rich repeat 1069..1090 CDD:275380 4/23 (17%)
leucine-rich repeat 1091..1114 CDD:275380 4/22 (18%)
leucine-rich repeat 1115..1161 CDD:275380 10/46 (22%)
leucine-rich repeat 1162..1190 CDD:275380 7/49 (14%)
PCC 1230..>1298 CDD:188093 20/73 (27%)
18wNP_476814.1 leucine-rich repeat 66..91 CDD:275380 11/39 (28%)
leucine-rich repeat 92..115 CDD:275380 9/23 (39%)
LRR_8 115..181 CDD:404697 27/109 (25%)
leucine-rich repeat 116..146 CDD:275380 12/68 (18%)
leucine-rich repeat 147..170 CDD:275380 11/27 (41%)
leucine-rich repeat 171..201 CDD:275380 5/29 (17%)
LRR 210..592 CDD:443914 125/428 (29%)
leucine-rich repeat 212..236 CDD:275380 4/23 (17%)
leucine-rich repeat 237..260 CDD:275380 8/28 (29%)
leucine-rich repeat 261..284 CDD:275380 7/22 (32%)
leucine-rich repeat 285..308 CDD:275380 9/26 (35%)
leucine-rich repeat 309..334 CDD:275380 9/24 (38%)
leucine-rich repeat 335..358 CDD:275380 9/22 (41%)
leucine-rich repeat 359..382 CDD:275380 9/22 (41%)
leucine-rich repeat 383..406 CDD:275380 8/22 (36%)
leucine-rich repeat 407..430 CDD:275380 9/45 (20%)
leucine-rich repeat 431..451 CDD:275380 7/20 (35%)
leucine-rich repeat 454..477 CDD:275380 5/22 (23%)
leucine-rich repeat 478..499 CDD:275380 6/20 (30%)
leucine-rich repeat 502..525 CDD:275380 7/22 (32%)
leucine-rich repeat 526..548 CDD:275380 8/29 (28%)
leucine-rich repeat 590..617 CDD:275380 5/26 (19%)
leucine-rich repeat 618..641 CDD:275380 5/22 (23%)
leucine-rich repeat 642..689 CDD:275380 12/48 (25%)
LRRCT 679..736 CDD:214507 17/75 (23%)
LRR <775..>920 CDD:443914 33/163 (20%)
leucine-rich repeat 775..796 CDD:275380 5/22 (23%)
leucine-rich repeat 797..817 CDD:275380 4/19 (21%)
leucine-rich repeat 818..841 CDD:275380 8/27 (30%)
leucine-rich repeat 842..865 CDD:275380 3/22 (14%)
leucine-rich repeat 866..889 CDD:275380 4/22 (18%)
leucine-rich repeat 890..911 CDD:275380 6/32 (19%)
TIR 1045..1183 CDD:214587
Blue background indicates that the domain is not in the aligned region.

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