DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG4168 and Nrros

DIOPT Version :10

Sequence 1:NP_609740.4 Gene:CG4168 / 34889 FlyBaseID:FBgn0028888 Length:1330 Species:Drosophila melanogaster
Sequence 2:NP_001020166.1 Gene:Nrros / 303875 RGDID:1310771 Length:692 Species:Rattus norvegicus


Alignment Length:785 Identity:198/785 - (25%)
Similarity:307/785 - (39%) Gaps:222/785 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   599 NLKQVSNESFAQMRELSYINLSFNQLKTLPRGLFQSDAHSHLVEIDLSYNGLERLEAQTFHSLGD 663
            ||..|.:...|..|.|.   |..|.|:.|.....|  |:..|.::.|....|:|:....||..|.
  Rat    47 NLASVPSGLPAHSRMLV---LDANPLRVLWNHSLQ--AYPRLEDLSLHSCHLDRISHWAFHEQGH 106

  Fly   664 LQTLNLQSNRLRTIARH---AFHNLEFLRYLDLSYNRLVNISHGAFTVLPNLAALDLMHNQLCSL 725
            ||.|.|..|||....:.   |.|.|..||.||||.|.|..          ::||  ||...|.||
  Rat   107 LQNLVLADNRLSENYKESATALHTLLRLRRLDLSGNSLTE----------DMAA--LMLQNLSSL 159

  Fly   726 SLKSFLYVSNTTTPLRLNVSHNHIASFYDELSSYMYIYQLDISHNHV--TKSDSFTNLANTLRFL 788
            .:.|..    ..|.:||:      .|.::.|..   :.:||:..|::  .:..:|..|.. ||.|
  Rat   160 EVVSLA----RNTLMRLD------DSVFEGLER---LVELDLQRNYIFEIEGGAFDGLTE-LRRL 210

  Fly   789 NLAHNQLGSLQSHAFGDLEFLEILNVAHNNLTSLRRRSFQGLNSLQELDLSHNQLDQLQVEQFSN 853
            |||:|.|..:...:...|.|   |||::|.|........:....|:.||||||||  |.......
  Rat   211 NLAYNNLPCIVDFSLTQLRF---LNVSYNILEWFLAAREEAAFELEILDLSHNQL--LFFPLLPQ 270

  Fly   854 LRKLRILRINSNRLRALPREVFMNTR------LEFLDIAEN-----QLSVWPVPAFTDIGFTLRS 907
            ..||..|.:..|.: ...||:: ||.      .:||.:..|     .:|:|...:.:|:. .||.
  Rat   271 CGKLHTLLLQDNSM-GFYRELY-NTSSPQEMVAQFLLVDGNVTNITTVSLWEEFSSSDLS-ALRF 332

  Fly   908 IQMSHNNLEYLDASMFINSQFLYDISLARNRITILPDNTFSFLNNLTNLDLSQNPLVTTNLREVF 972
            :.||.|.|.:                        |||.......:|::|:|:||.|...::||  
  Rat   333 LDMSQNQLRH------------------------LPDGFLKKTPSLSHLNLNQNCLTKLHIRE-- 371

  Fly   973 VHTPRLRKLSLHHMGLYVLPPLKLPLLSYLDVSGNYLQE--LSP--LGSLRHLRHVNVSHNKLTN 1033
                       |.      ||   ..|:.||:|.|.|.|  |:|  .|||::||..|:|.|:|..
  Rat   372 -----------HE------PP---GALTELDLSRNQLAELHLAPGLTGSLKNLRVFNLSSNQLLG 416

  Fly  1034 ASCAAEHLPPSVRVLDLAHN---------------PLRRITLHDLASLRHLAELNILDVKVTNPQ 1083
            ......|...|:..||::||               |...:...::||||.|: |:...:|.....
  Rat   417 VPTGLFHSASSITTLDMSHNQISLCPQTVPLDWEEPSSCVDFRNMASLRSLS-LDGCGLKALQDC 480

  Fly  1084 AFSKLRSLRKLHASS-----HANLGEIVARIPGLQQLRVHCLEPNIG------QQLFAKLANNTK 1137
            .|.. .||..|..||     :.::..:.|..|.||.|.:.    |:|      :..|:...|   
  Rat   481 PFQG-TSLTHLDLSSNWGILNGSVSPLSAVAPTLQVLSLR----NVGLGSGAAEMDFSGFGN--- 537

  Fly  1138 IRLLELYGSNVQTIAPDVFTGLSRSQRLQVKISHTRISDLPPGIFYALREVPHLSIDISHNRINA 1202
            :|.|:|.|:::.:     |.....|..||                         ::|:..|.:.|
  Rat   538 LRELDLSGNSLTS-----FPKFKGSSALQ-------------------------TLDLRRNSLTA 572

  Fly  1203 LAADSFYPNKSYWDAVGTRSIMGGLIT---SHNPLECECGLVWFG---HWLRRWLRESAQIKVIQ 1261
            |      |.:     |.:...:.||.|   |.||.:| ||:..:|   |:     :..|.:.:: 
  Rat   573 L------PQR-----VVSEQPLRGLQTIYLSQNPYDC-CGVEGWGALQHF-----KTIADLSMV- 619

  Fly  1262 KDDLKRMVQRARANTCHDPTSGRHLPILEI---FPEDLLCQASALSSSGQRIFLLSFAMALLIPI 1323
                          ||:  .|.:.:.::|:   .|:|  |:...:.:.       .|.:.|::|.
  Rat   620 --------------TCN--LSSKIIRVVELPEGIPQD--CKWGQVDTG-------LFYLVLILPS 659

  Fly  1324 VMTTM 1328
            .:|.:
  Rat   660 CLTLL 664

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG4168NP_609740.4 PRK15370 <69..>353 CDD:185268
leucine-rich repeat 99..118 CDD:275380
leucine-rich repeat 122..146 CDD:275380
leucine-rich repeat 147..170 CDD:275380
leucine-rich repeat 171..194 CDD:275380
leucine-rich repeat 195..214 CDD:275380
leucine-rich repeat 215..236 CDD:275380
leucine-rich repeat 266..287 CDD:275380
leucine-rich repeat 288..311 CDD:275380
leucine-rich repeat 312..338 CDD:275380
LRR <338..651 CDD:443914 14/51 (27%)
leucine-rich repeat 339..365 CDD:275380
leucine-rich repeat 366..388 CDD:275380
leucine-rich repeat 389..412 CDD:275380
leucine-rich repeat 414..436 CDD:275380
leucine-rich repeat 437..459 CDD:275380
leucine-rich repeat 460..483 CDD:275380
leucine-rich repeat 484..510 CDD:275380
leucine-rich repeat 511..534 CDD:275380
leucine-rich repeat 535..589 CDD:275380
LRR 543..971 CDD:443914 110/387 (28%)
leucine-rich repeat 590..613 CDD:275380 4/13 (31%)
leucine-rich repeat 614..639 CDD:275380 7/24 (29%)
leucine-rich repeat 640..663 CDD:275380 6/22 (27%)
leucine-rich repeat 664..687 CDD:275380 10/25 (40%)
leucine-rich repeat 688..711 CDD:275380 8/22 (36%)
leucine-rich repeat 712..735 CDD:275380 8/22 (36%)
leucine-rich repeat 740..783 CDD:275380 9/44 (20%)
leucine-rich repeat 785..808 CDD:275380 9/22 (41%)
leucine-rich repeat 809..832 CDD:275380 5/22 (23%)
leucine-rich repeat 833..856 CDD:275380 10/22 (45%)
leucine-rich repeat 857..879 CDD:275380 6/21 (29%)
leucine-rich repeat 880..900 CDD:275380 5/24 (21%)
leucine-rich repeat 905..928 CDD:275380 6/22 (27%)
LRR 911..>1203 CDD:443914 74/321 (23%)
leucine-rich repeat 929..952 CDD:275380 3/22 (14%)
leucine-rich repeat 953..977 CDD:275380 8/23 (35%)
leucine-rich repeat 978..1020 CDD:275380 15/45 (33%)
leucine-rich repeat 1045..1068 CDD:275380 8/37 (22%)
leucine-rich repeat 1069..1090 CDD:275380 4/20 (20%)
leucine-rich repeat 1091..1114 CDD:275380 7/27 (26%)
leucine-rich repeat 1115..1161 CDD:275380 10/51 (20%)
leucine-rich repeat 1162..1190 CDD:275380 3/27 (11%)
PCC 1230..>1298 CDD:188093 15/73 (21%)
NrrosNP_001020166.1 leucine-rich repeat 39..57 CDD:275380 3/9 (33%)
LRR 1. /evidence=ECO:0000255 58..79 7/25 (28%)
leucine-rich repeat 60..82 CDD:275380 8/26 (31%)
LRR 2. /evidence=ECO:0000255 82..103 5/20 (25%)
leucine-rich repeat 83..106 CDD:275380 6/22 (27%)
LRR 3. /evidence=ECO:0000255 106..127 7/20 (35%)
leucine-rich repeat 107..158 CDD:275380 23/62 (37%)
LRR 4. /evidence=ECO:0000255 133..155 12/33 (36%)
LRR <140..414 CDD:443914 97/353 (27%)
LRR 5. /evidence=ECO:0000255 158..179 7/30 (23%)
leucine-rich repeat 159..182 CDD:275380 7/32 (22%)
LRR 6. /evidence=ECO:0000255 182..203 4/23 (17%)
leucine-rich repeat 183..206 CDD:275380 5/22 (23%)
LRR 7. /evidence=ECO:0000255 206..227 8/21 (38%)
leucine-rich repeat 207..251 CDD:275380 15/46 (33%)
LRR 8. /evidence=ECO:0000255 228..239 6/13 (46%)
LRR 9. /evidence=ECO:0000255 251..272 10/22 (45%)
leucine-rich repeat 252..273 CDD:275380 10/22 (45%)
LRR 10. /evidence=ECO:0000255 273..294 7/22 (32%)
leucine-rich repeat 274..329 CDD:275380 13/57 (23%)
LRR 293..>595 CDD:443914 92/398 (23%)
LRR 11. /evidence=ECO:0000255 329..350 9/44 (20%)
leucine-rich repeat 330..353 CDD:275380 9/46 (20%)
LRR 12. /evidence=ECO:0000255 353..374 9/39 (23%)
leucine-rich repeat 354..377 CDD:275380 11/44 (25%)
LRR 13. /evidence=ECO:0000255 377..398 9/20 (45%)
leucine-rich repeat 378..403 CDD:275380 12/24 (50%)
LRR 14. /evidence=ECO:0000255 403..424 6/20 (30%)
leucine-rich repeat 404..427 CDD:275380 7/22 (32%)
LRR 15. /evidence=ECO:0000255 427..448 5/20 (25%)
leucine-rich repeat 428..463 CDD:275380 5/34 (15%)
LRR 16. /evidence=ECO:0000255 463..484 7/21 (33%)
leucine-rich repeat 464..486 CDD:275380 6/23 (26%)
LRR 17. /evidence=ECO:0000255 486..507 5/20 (25%)
leucine-rich repeat 487..512 CDD:275380 5/24 (21%)
LRR 18. /evidence=ECO:0000255 512..533 5/24 (21%)
leucine-rich repeat 513..537 CDD:275380 6/27 (22%)
LRR 19. /evidence=ECO:0000255 537..558 6/28 (21%)
leucine-rich repeat 538..559 CDD:275380 6/25 (24%)
LRR 20. /evidence=ECO:0000255 559..580 8/56 (14%)
LRR 21. /evidence=ECO:0000255 585..605 9/20 (45%)
Blue background indicates that the domain is not in the aligned region.

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