Protein Alignment CG4168 and LRRC70

DIOPT Version :10

• Sequence 1: NP_609740.4
• Gene: CG4168 / 34889
• FlyBaseID: FBgn0028888
• Length: 1330
• Species: Drosophila melanogaster
• Sequence 2: NP_852607.3
• Gene: LRRC70 / 100130733
• HGNCID: 35155
• Length: 622
• Species: Homo sapiens
• Alignment Length: 636
• Identity: 149/636 - (23%)
• Similarity: 237/636 - (37%)
• Gaps: 213/636 - (33%)

  Fly   584 LLPLSQLIWLGLDNNNLKQVSNESFAQMRELSYINLSFNQLKTLPRGLFQSDAHSHLVEIDLSYN 648
            |..|..|:.|.|||:|:..|..::|.|:|.|.::.|:.|.:|.|..|:|:  ...:|..:.|.||
Human    80 LTGLHSLVALYLDNSNILYVYPKAFVQLRHLYFLFLNNNFIKRLDPGIFK--GLLNLRNLYLQYN 142

  Fly   649 GLERLEAQTFHSLGDLQTLNLQSNRLRTIARHAFHNLEFLRYLDLSYNRLVNISHGAFTVLPNLA 713
            .:..:....|:.|..:|.||||.|||..:....|..:..||.||||.|.::.||...|..|.|||
Human   143 QVSFVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRILDLSNNNILRISESGFQHLENLA 207

  Fly   714 ALDLMHNQLCSLSLKSFLYVSNTTTPLRLNVSHNHIASFYDELSSYMYIYQLDISHNHVTKSDSF 778
            .|.|..|.|..:...:|                                        .|.||
Human   208 CLYLGSNNLTKVPSNAF----------------------------------------EVLKS--- 229

  Fly   779 TNLANTLRFLNLAHNQLGSLQSHAFGDLEFLEILNVAHNNLTSLRRRSFQGLNSLQELDLSHNQL 843
                  ||.|:|:||.:.::|..||..|..||.|.:.::.:.::.|..|.|:|:|:.|.||||.|
Human   230 ------LRRLSLSHNPIEAIQPFAFKGLANLEYLLLKNSRIRNVTRDGFSGINNLKHLILSHNDL 288

  Fly   844 DQLQVEQFSNLRKLRILRINSNRLRALPREVFMNTRLEFLDIAENQLSVWPVPAFTDIGFTLRSI 908
            :.|..:.||.|:.|..|:::.||:.::..:.|.|                       :|.:|:.:
Human   289 ENLNSDTFSLLKNLIYLKLDRNRIISIDNDTFEN-----------------------MGASLKIL 330

  Fly   909 QMSHNNLEYLDASMFINSQFLYDISLARNRITILPDNTFSFLNNLTNLDLSQNP----------- 962
            .:|.|||                        |.|.......|::|.:|..:.||
Human   331 NLSFNNL------------------------TALHPRVLKPLSSLIHLQANSNPWECNCKLLGLR 371

  Fly   963 ------LVTTNLREVFVHTPRLRKLSLHHMGLYVLPPLKLPLLSYLDVSGNYLQELSPLGSLRHL 1021
                  .:|.|:  ...:.|.:|..:|.::.:...      :.|.::||..:....||     |:
Human   372 DWLASSAITLNI--YCQNPPSMRGRALRYINITNC------VTSSINVSRAWAVVKSP-----HI 423

  Fly  1022 RHVNVS-----HNKLTNASCAA----------EHLP--PSVRVL--DLAHNPLR----------- 1056
            .|...:     |...||.|...          |.:|  |:.|..  :...|||.
Human   424 HHKTTALMMAWHKVTTNGSPLENTETENITFWERIPTSPAGRFFQENAFGNPLETTAVLPVQIQL 488

  Fly  1057 --RITL---------HDLASLRHLAELNIL-DVKVTNPQAFSKLRSL------------------ 1091
              .:||         :|.||:.....|... :|:..| :||..|.:.
Human   489 TTSVTLNLEKNSALPNDAASMSGKTSLICTQEVEKLN-EAFDILLAFFILACVLIIFLIYKVVQF 552

  Fly  1092 -RKLHASSHANLG-------------EIVARI----------PGLQQLRVH 1118
             :||.||.::...             .:.|.|          |||:|:|:|
Human   553 KQKLKASENSRENRLEYYSFYQSARYNVTASICNTSPNSLESPGLEQIRLH 603

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4168	NP_609740.4	PRK15370	<69..>353	CDD:185268
		leucine-rich repeat	99..118	CDD:275380
		leucine-rich repeat	122..146	CDD:275380
		leucine-rich repeat	147..170	CDD:275380
		leucine-rich repeat	171..194	CDD:275380
		leucine-rich repeat	195..214	CDD:275380
		leucine-rich repeat	215..236	CDD:275380
		leucine-rich repeat	266..287	CDD:275380
		leucine-rich repeat	288..311	CDD:275380
		leucine-rich repeat	312..338	CDD:275380
		LRR	<338..651	CDD:443914	23/66 (35%)
		leucine-rich repeat	339..365	CDD:275380
		leucine-rich repeat	366..388	CDD:275380
		leucine-rich repeat	389..412	CDD:275380
		leucine-rich repeat	414..436	CDD:275380
		leucine-rich repeat	437..459	CDD:275380
		leucine-rich repeat	460..483	CDD:275380
		leucine-rich repeat	484..510	CDD:275380
		leucine-rich repeat	511..534	CDD:275380
		leucine-rich repeat	535..589	CDD:275380	2/4 (50%)
		LRR	543..971	CDD:443914	105/403 (26%)
		leucine-rich repeat	590..613	CDD:275380	9/22 (41%)
		leucine-rich repeat	614..639	CDD:275380	7/24 (29%)
		leucine-rich repeat	640..663	CDD:275380	6/22 (27%)
		leucine-rich repeat	664..687	CDD:275380	9/22 (41%)
		leucine-rich repeat	688..711	CDD:275380	11/22 (50%)
		leucine-rich repeat	712..735	CDD:275380	7/22 (32%)
		leucine-rich repeat	740..783	CDD:275380	3/42 (7%)
		leucine-rich repeat	785..808	CDD:275380	10/22 (45%)
		leucine-rich repeat	809..832	CDD:275380	6/22 (27%)
		leucine-rich repeat	833..856	CDD:275380	11/22 (50%)
		leucine-rich repeat	857..879	CDD:275380	6/21 (29%)
		leucine-rich repeat	880..900	CDD:275380	0/19 (0%)
		leucine-rich repeat	905..928	CDD:275380	5/22 (23%)
		LRR	911..>1203	CDD:443914	57/309 (18%)
		leucine-rich repeat	929..952	CDD:275380	3/22 (14%)
		leucine-rich repeat	953..977	CDD:275380	6/40 (15%)
		leucine-rich repeat	978..1020	CDD:275380	7/41 (17%)
		leucine-rich repeat	1045..1068	CDD:275380	9/46 (20%)
		leucine-rich repeat	1069..1090	CDD:275380	6/21 (29%)
		leucine-rich repeat	1091..1114	CDD:275380	9/64 (14%)
		leucine-rich repeat	1115..1161	CDD:275380	2/4 (50%)
		leucine-rich repeat	1162..1190	CDD:275380
		PCC	1230..>1298	CDD:188093
LRRC70	NP_852607.3	LRRNT	31..59	CDD:396168
		LRR	49..>383	CDD:443914	104/400 (26%)
		LRR 1	61..82		1/1 (100%)
		leucine-rich repeat	65..85	CDD:275380	2/4 (50%)
		LRR 2	85..106		8/20 (40%)
		leucine-rich repeat	86..109	CDD:275380	9/22 (41%)
		LRR 3	109..130		7/22 (32%)
		leucine-rich repeat	110..133	CDD:275380	7/24 (29%)
		LRR 4	133..154		5/20 (25%)
		leucine-rich repeat	134..157	CDD:275380	6/22 (27%)
		LRR 5	157..178		9/20 (45%)
		leucine-rich repeat	158..181	CDD:275380	9/22 (41%)
		LRR 6	181..202		10/20 (50%)
		leucine-rich repeat	182..205	CDD:275380	11/22 (50%)
		LRR 7	205..226		8/60 (13%)
		leucine-rich repeat	206..229	CDD:275380	8/62 (13%)
		LRR 8	229..250		10/29 (34%)
		leucine-rich repeat	230..253	CDD:275380	10/22 (45%)
		LRR 9	253..274		5/20 (25%)
		leucine-rich repeat	254..277	CDD:275380	6/22 (27%)
		LRR 10	277..298		9/20 (45%)
		leucine-rich repeat	278..301	CDD:275380	11/22 (50%)
		LRR 11	301..322		5/20 (25%)
		leucine-rich repeat	302..326	CDD:275380	7/46 (15%)
		LRR 12	326..347		7/44 (16%)
		leucine-rich repeat	327..348	CDD:275380	7/44 (16%)