DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TfIIS and Med26

DIOPT Version :9

Sequence 1:	NP_001260457.1	Gene:	TfIIS / 34883	FlyBaseID:	FBgn0010422	Length:	313	Species:	Drosophila melanogaster
Sequence 2:	NP_081761.2	Gene:	Med26 / 70625	MGIID:	1917875	Length:	588	Species:	Mus musculus

Alignment Length:	246	Identity:	54/246 - (21%)
Similarity:	100/246 - (40%)	Gaps:	62/246 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 LDLLKALQTLNINLDILTKTRIGMTVNELRKSSKDDEVIALAKTLIKNWKRFLASPAPTTPNNSS 92
            |:::.:|:...|..:.|.:||:|..:|::||.:|::|:...||.|:::|::.:   .|...|..:
Mouse    32 LEVISSLERYPITKEALEETRLGKLINDVRKKTKNEELAKRAKRLLRSWQKLI---EPVHQNEVA 93

  Fly    93 AK-----EGSSNN-----------SSASKSTSAAKSSSSIS----------------GKDKSSSS 125
            .:     .||:|.           :.|.||....|:.:.|.                |..:....
Mouse    94 LRALAGAAGSANGGAHNCRPEMGVAGAPKSIHDLKNRNDIQRLPGQRLDRLGSRKRRGDQRDLGH 158

  Fly   126 SSSKDKEKKGSTS---SSQTSFPSGGMTDAVRIKCREMLATALKIGEVPEGCGE--PEEMAAELE 185
            .....|..|||..   .:.:..|:.|::.:     .|.|.:.|      :|.|.  |:....|..
Mouse   159 PGPPHKVSKGSPDPLVPNASPLPTNGISGS-----PESLPSPL------DGSGHLGPDGSRLEPS 212

  Fly   186 DAIYSEFNNTDMKYKNRIRSRVANLKDPKNPGL-RGNFMCGAVTAKQLAKM 235
            |   :|.::|.:.. |.:|.|      |.:||| :....|....|.||.::
Mouse   213 D---NEKHSTKIPV-NAVRPR------PSSPGLGKPPVPCLQTKAAQLQQL 253

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TfIIS	NP_001260457.1	TFSII	5..313	CDD:273592	54/246 (22%)
		TFS2N	7..82	CDD:197766	16/53 (30%)
		TFIIS_M	151..257	CDD:284835	21/88 (24%)
		Zn-ribbon_TFIIS	266..312	CDD:259796
Med26	NP_081761.2	TFS2N	12..86	CDD:197766	16/56 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	112..393		33/163 (20%)
		Med26_M	178..405	CDD:292322	23/97 (24%)
		Med26_C	407..586	CDD:292321
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	412..441
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1594
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900