DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ck and myo-2

DIOPT Version :9

Sequence 1:	NP_001285949.1	Gene:	ck / 34882	FlyBaseID:	FBgn0000317	Length:	2167	Species:	Drosophila melanogaster
Sequence 2:	NP_510092.2	Gene:	myo-2 / 181404	WormBaseID:	WBGene00003514	Length:	1947	Species:	Caenorhabditis elegans

Alignment Length:	1497	Identity:	423/1497 - (28%)
Similarity:	668/1497 - (44%)	Gaps:	245/1497 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 IWIEPASGREFDVAIGARVVSAEGRRIQVRDDDGDEVWLAPERRIKAMHASSVQGVEDMISLGDL 74
            :||..:.    |..|...:....|..:.|....|.|..:..: .::.|:....:..|||.:|..|
Worm    33 VWIPDSE----DGYIEGVITKTAGDNVTVSIGQGAEKTVKKD-VVQEMNPPKFEKTEDMSNLTFL 92

  Fly    75 HEAGILRNLLIRYKENLIYTYTGSILVAVNPYQILPIYTGDQIKLYKERKIGELPPHIFAIGDNA 139
            ::|.:|.||..||...|||||:|...|.:|||:.|||||....:::..::..|:|||:||:.|.|
Worm    93 NDASVLYNLKARYAAMLIYTYSGLFCVVINPYKRLPIYTDSVARMFMGKRRTEMPPHLFAVSDEA 157

  Fly   140 YAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAAISG-------------------KHSWIEQ 185
            |.:|.:..::|.::|:|||||||||:||.::.|.||:..                   |...:|.
Worm   158 YRNMLQNHENQSMLITGESGAGKTENTKKVISYFAAVGAAQQETFGAKKAATEEDKNKKKVTLED 222

  Fly   186 QILEANPILEAFGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSERNY 250
            ||::.||:|||||||||:||:|||||||:|.||||..|.:....||.|||||||::.|...||.|
Worm   223 QIVQTNPVLEAFGNAKTVRNNNSSRFGKFIRIHFSKQGRVASCDIEHYLLEKSRVIRQAPGERCY 287

  Fly   251 HVFYCILAGLSADEKSRLDLGM-AADYKYLTGGNSITCEGRDDAAEFSDIRSAMKVLLFSDQEIW 314
            |:||.:.:....:.|..|.|.. ..||.::.....| .:|.:|..|......|..:|.|:..|..
Worm   288 HIFYQVFSDYLPNLKKDLLLNKPVKDYWFIAQAELI-IDGINDKEEHQLTDEAFDILKFTPTEKM 351

  Fly   315 EIIKLLAALLHCGNIKYKATVVDNL---DATEIPEHINVERVAGLLGLPIQPLIDALTRRTLFAH 376
            |..:|:||::|.||:|:|....:..   |.|:     :.||.|...|:..:..:.||||..:...
Worm   352 ECYRLVAAMMHMGNMKFKQRPREEQAEPDGTD-----DAERAAKCFGIDSEEFLKALTRPRVKVG 411

  Fly   377 GETVVSTLSRDQSVD----VRDAFVKGIYGRMFVHIVRKINTAIFKPRGTSR-NAIGVLDIFGFE 436
            .|.|    ::.|:::    ...|..||:|.|:|..:|:|.|..: ..:|.|| :.||||||.|||
Worm   412 NEWV----NKGQNIEQVNWAVGAMAKGLYSRIFNWLVKKCNQTL-DQKGISRDHFIGVLDIAGFE 471

  Fly   437 NFDQNSFEQFCINYANENLQQFFVQHIFKLEQEEYNHEAINWQHIEF-VDNQDALDLIAIKQLNI 500
            .||.|||||..||:.||.|||||..|:|.||||||..|.|.|..|:| :|.|..::||. |.|.|
Worm   472 IFDFNSFEQLWINFVNEKLQQFFNHHMFVLEQEEYAREGIQWTFIDFGLDLQACIELIE-KPLGI 535

  Fly   501 MALIDEEARFPKGTDQTMLAKLHKTH-GSHKNYLKPK----SDINTSFGLNHFAGVVFYDTRGFL 560
            :|::|||...||.||.|:..||...| |.|.|:.|||    ......|.:.|:||.|.|:...:|
Worm   536 IAMLDEECIVPKATDLTLAQKLIDQHLGKHPNFEKPKPPKGKQAEAHFAMRHYAGTVRYNCLNWL 600

  Fly   561 DKNRDTFSPDLLHLVSQSTNKFL----RQIFAQDIEMGAETRKRTP------------TLSTQFR 609
            :||:|..:..::.::..|....|    .|.:....|..|...|.|.            |:|..:|
Worm   601 EKNKDPLNDTVVTVMKASKEHALIVEVWQDYTTQEEAAAAAAKGTAGAKKKGKSGSFMTVSMLYR 665

  Fly   610 KSLDALMKTLSSCQPFFIRCIKPNELKKPMMFDRGLCCRQLRYSGMMETIRIRRAGYPIRHGFRE 674
            :||:.||..|.|..|.|||||.|||.|...:.|.||...||..:|::|.|||.|.|:|.|....:
Worm   666 ESLNKLMTMLHSTHPHFIRCIIPNEKKASGVIDAGLVLNQLTCNGVLEGIRICRKGFPNRTLHPD 730

  Fly   675 FVERYRFLIPGVPPAHRTDCQAATSRICAVV-----LGKSDYQLGHTKVFLKDAHDLFLEQERDR 734
            ||:||..|........:||.:..::.:.|.:     |.:.::::|.||||.|......||..||:
Worm   731 FVQRYALLAADESIIGKTDAKKGSALMLARLVKEKKLEEENFRVGLTKVFFKAGIVAHLEDLRDQ 795

  Fly   735 VLTRKILILQRSIRGWVY-----RRRFLRLRAAAITVQRFWKGYAQRKRYRNMRVGYMRLQALIR 794
            .|.:.|..||..|| |.|     :||..::.|..| :||..:.:|:.:.:...:: |.:::.|:.
Worm   796 SLAQLITGLQAQIR-WYYQTIERKRRVEKITALKI-IQRNIRSWAELRTWVWFKL-YGKVKPLVN 857

  Fly   795 SRVLSHRFRHLRGHIVGL-------QAHARGYLVRREYGHKMWAVIKIQSHV---------RRMI 843
            |..:..::..|:..:..|       :...|......|..:|..|.:..|...         .||.
Worm   858 SGKIEAQYEKLQETVATLKDTVVQEEEKKRQLQEGAERLNKETADLLAQLEASKGSTREVEERMT 922

  Fly   844 AMRRY------------RKLRLEHKQFAEVLQLRKLEEQELLH---------------RGNKHAR 881
            ||...            :||.:|..:..|:.:.:||.|.|...               ...|:|:
Worm   923 AMNEQKVALEGKLADASKKLEVEEARAVEINKQKKLVEAECADLKKNCQDVDLSLRKVEAEKNAK 987

  Fly   882 EIAEQHYRDRLHELERREIQEQLENRRRVEVNMNIINDAARKQEEPVDDGKLVEAMFDFLPDSSS 946
            |...:..:|.:.:.:....:...|.:.:.|.|..:..|....:|:.:...||...:...|.||
Worm   988 EHQIRALQDEMRQQDENISKLNKERKNQEEQNKKLTEDLQAAEEQNLAANKLKAKLMQSLEDS-- 1050

  Fly   947 DAPTPHGGRETSVFNDLPHAQNVNQDDIIAPIHISEDEEDLSEFKFQKFAATYFQGNVNHQYAKK 1011
                     |.::..:..:..:::::...|...:...:|.|.|.            |.:...|:.
Worm  1051 ---------EQTMEREKRNRADMDKNKRKAEGELKIAQETLEEL------------NKSKSDAEN 1094

  Fly  1012 ALKHPLLPLHTQGDQLAAQALWITILRFTGDMPEPKYHTM-DRM-DTTSVMSKVTATLGRNFIRS 1074
            ||:.....|||.|.:|..:...:..|:......|.:...: |:: |......:..        ||
Worm  1095 ALRRKETELHTLGMKLEDEQAAVAKLQKGIQQDEARVKDLHDQLADEKDARQRAD--------RS 1151

  Fly  1075 KEFQEAQLMGLDPDAFLKQKPRSIRHKLVSLTL-KRKNKLGEDVRRRLQDDEYTADSYQSWLQSR 1138
            :..|:|:.     |...:|.....|.....:.| |:|:.....:||.|::.........:.|:.:
Worm  1152 RADQQAEY-----DELTEQLEDQARATAAQIELGKKKDAELTKLRRDLEESGLKFGEQLTVLKKK 1211

  Fly  1139 PTSNLEKLHFIIGHGILRAELRDEIYCQICKQLTNNPLKSSHARGWILLSLCVGCFAPSEKFVNY 1203
            .:..::             ||.|:|. |:.||......:..|.:..         |..|...::.
Worm  1212 GSDAIQ-------------ELSDQIE-QLQKQKGRIEKEKGHMQRE---------FDESSAALDQ 1253

  Fly  1204 ---LRAFIREGPPGYAPYCEERLKRTFNNGTRNQPPSWLELQATKSKKPIMLPITFMDGNTKTLL 1265
               |||.......||    |.||..             |.|:|.:..:.:.   .|:....: |.
Worm  1254 EAKLRADQERIAKGY----EVRLLE-------------LRLKADEQSRQLQ---DFVSSKGR-LN 1297

  Fly  1266 ADSATTARELCNQLSDKIS----LKDQFGFSLYIALFDKVSSLGSGGDHVMDAISQCEQYAKEQ- 1325
            ::::..||:: .:|..||.    ||.||...|               ||   |..|.|:.::|:
Worm  1298 SENSDLARQV-EELEAKIQAANRLKLQFSNEL---------------DH---AKRQAEEESRERQ 1343

  Fly  1326 --GAQERNAPWRLFFRKEIFAPWHEPTHDQVA-TNLIYQQVVR-GVKFGEYRCDKEEDLAMIAAQ 1386
              ....:|....|...|       |...|:|| .|...:|:.: .|:..::| .|.|...:|.|.
Worm  1344 NLSNLSKNLARELEQLK-------ESIEDEVAGKNEASRQLSKASVELDQWR-TKFETEGLIGAD 1400

  Fly  1387 QY 1388
            ::
Worm  1401 EF 1402

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ck	NP_001285949.1	MYSc	64..733	CDD:214580	275/723 (38%)
		MYSc_Myo7	77..721	CDD:276832	267/698 (38%)
		MyTH4	<1138..1245	CDD:214535	21/109 (19%)
		B41	1251..1467	CDD:214604	33/147 (22%)
		FERM_B-lobe	1355..1439	CDD:271216	9/36 (25%)
		FERM_C1_MyoVII	1461..1559	CDD:270019
		SH3	1560..1624	CDD:302595
		MyTH4	1701..1849	CDD:214535
		B41	1856..2068	CDD:214604
		FERM_M	1966..2068	CDD:278785
		FERM_C2_MyoVII	2064..2159	CDD:270020
myo-2	NP_510092.2	Myosin_N	31..68	CDD:280832	8/38 (21%)
		Myosin_head	83..782	CDD:278492	272/710 (38%)
		MYSc_class_II	95..782	CDD:276951	267/698 (38%)
		Myosin_tail_1	876..1939	CDD:279860	117/634 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910