Protein Alignment ck and myo-2

DIOPT Version :10

• Sequence 1: NP_523571.1
• Gene: ck / 34882
• FlyBaseID: FBgn0000317
• Length: 2167
• Species: Drosophila melanogaster
• Sequence 2: NP_510092.2
• Gene: myo-2 / 181404
• WormBaseID: WBGene00003514
• Length: 1947
• Species: Caenorhabditis elegans
• Alignment Length: 1497
• Identity: 423/1497 - (28%)
• Similarity: 668/1497 - (44%)
• Gaps: 245/1497 - (16%)

  Fly    10 IWIEPASGREFDVAIGARVVSAEGRRIQVRDDDGDEVWLAPERRIKAMHASSVQGVEDMISLGDL 74
            :||..:.    |..|...:....|..:.|....|.|..:..: .::.|:....:..|||.:|..|
 Worm    33 VWIPDSE----DGYIEGVITKTAGDNVTVSIGQGAEKTVKKD-VVQEMNPPKFEKTEDMSNLTFL 92

  Fly    75 HEAGILRNLLIRYKENLIYTYTGSILVAVNPYQILPIYTGDQIKLYKERKIGELPPHIFAIGDNA 139
            ::|.:|.||..||...|||||:|...|.:|||:.|||||....:::..::..|:|||:||:.|.|
 Worm    93 NDASVLYNLKARYAAMLIYTYSGLFCVVINPYKRLPIYTDSVARMFMGKRRTEMPPHLFAVSDEA 157

  Fly   140 YAHMKRYRQDQCIVISGESGAGKTESTKLILQYLAAISG-------------------KHSWIEQ 185
            |.:|.:..::|.::|:|||||||||:||.::.|.||:..                   |...:|.
 Worm   158 YRNMLQNHENQSMLITGESGAGKTENTKKVISYFAAVGAAQQETFGAKKAATEEDKNKKKVTLED 222

  Fly   186 QILEANPILEAFGNAKTIRNDNSSRFGKYIDIHFSANGVIEGAKIEQYLLEKSRIVSQNHSERNY 250
            ||::.||:|||||||||:||:|||||||:|.||||..|.:....||.|||||||::.|...||.|
 Worm   223 QIVQTNPVLEAFGNAKTVRNNNSSRFGKFIRIHFSKQGRVASCDIEHYLLEKSRVIRQAPGERCY 287

  Fly   251 HVFYCILAGLSADEKSRLDLGM-AADYKYLTGGNSITCEGRDDAAEFSDIRSAMKVLLFSDQEIW 314
            |:||.:.:....:.|..|.|.. ..||.::.....| .:|.:|..|......|..:|.|:..|..
 Worm   288 HIFYQVFSDYLPNLKKDLLLNKPVKDYWFIAQAELI-IDGINDKEEHQLTDEAFDILKFTPTEKM 351

  Fly   315 EIIKLLAALLHCGNIKYKATVVDNL---DATEIPEHINVERVAGLLGLPIQPLIDALTRRTLFAH 376
            |..:|:||::|.||:|:|....:..   |.|:     :.||.|...|:..:..:.||||..:...
 Worm   352 ECYRLVAAMMHMGNMKFKQRPREEQAEPDGTD-----DAERAAKCFGIDSEEFLKALTRPRVKVG 411

  Fly   377 GETVVSTLSRDQSVD----VRDAFVKGIYGRMFVHIVRKINTAIFKPRGTSR-NAIGVLDIFGFE 436
            .|.|    ::.|:::    ...|..||:|.|:|..:|:|.|..: ..:|.|| :.||||||.|||
 Worm   412 NEWV----NKGQNIEQVNWAVGAMAKGLYSRIFNWLVKKCNQTL-DQKGISRDHFIGVLDIAGFE 471

  Fly   437 NFDQNSFEQFCINYANENLQQFFVQHIFKLEQEEYNHEAINWQHIEF-VDNQDALDLIAIKQLNI 500
            .||.|||||..||:.||.|||||..|:|.||||||..|.|.|..|:| :|.|..::||. |.|.|
 Worm   472 IFDFNSFEQLWINFVNEKLQQFFNHHMFVLEQEEYAREGIQWTFIDFGLDLQACIELIE-KPLGI 535

  Fly   501 MALIDEEARFPKGTDQTMLAKLHKTH-GSHKNYLKPK----SDINTSFGLNHFAGVVFYDTRGFL 560
            :|::|||...||.||.|:..||...| |.|.|:.|||    ......|.:.|:||.|.|:...:|
 Worm   536 IAMLDEECIVPKATDLTLAQKLIDQHLGKHPNFEKPKPPKGKQAEAHFAMRHYAGTVRYNCLNWL 600

  Fly   561 DKNRDTFSPDLLHLVSQSTNKFL----RQIFAQDIEMGAETRKRTP------------TLSTQFR 609
            :||:|..:..::.::..|....|    .|.:....|..|...|.|.            |:|..:|
 Worm   601 EKNKDPLNDTVVTVMKASKEHALIVEVWQDYTTQEEAAAAAAKGTAGAKKKGKSGSFMTVSMLYR 665

  Fly   610 KSLDALMKTLSSCQPFFIRCIKPNELKKPMMFDRGLCCRQLRYSGMMETIRIRRAGYPIRHGFRE 674
            :||:.||..|.|..|.|||||.|||.|...:.|.||...||..:|::|.|||.|.|:|.|....:
 Worm   666 ESLNKLMTMLHSTHPHFIRCIIPNEKKASGVIDAGLVLNQLTCNGVLEGIRICRKGFPNRTLHPD 730

  Fly   675 FVERYRFLIPGVPPAHRTDCQAATSRICAVV-----LGKSDYQLGHTKVFLKDAHDLFLEQERDR 734
            ||:||..|........:||.:..::.:.|.:     |.:.::::|.||||.|......||..||:
 Worm   731 FVQRYALLAADESIIGKTDAKKGSALMLARLVKEKKLEEENFRVGLTKVFFKAGIVAHLEDLRDQ 795

  Fly   735 VLTRKILILQRSIRGWVY-----RRRFLRLRAAAITVQRFWKGYAQRKRYRNMRVGYMRLQALIR 794
            .|.:.|..||..|| |.|     :||..::.|..| :||..:.:|:.:.:...:: |.:::.|:.
 Worm   796 SLAQLITGLQAQIR-WYYQTIERKRRVEKITALKI-IQRNIRSWAELRTWVWFKL-YGKVKPLVN 857

  Fly   795 SRVLSHRFRHLRGHIVGL-------QAHARGYLVRREYGHKMWAVIKIQSHV---------RRMI 843
            |..:..::..|:..:..|       :...|......|..:|..|.:..|...         .||.
 Worm   858 SGKIEAQYEKLQETVATLKDTVVQEEEKKRQLQEGAERLNKETADLLAQLEASKGSTREVEERMT 922

  Fly   844 AMRRY------------RKLRLEHKQFAEVLQLRKLEEQELLH---------------RGNKHAR 881
            ||...            :||.:|..:..|:.:.:||.|.|...               ...|:|:
 Worm   923 AMNEQKVALEGKLADASKKLEVEEARAVEINKQKKLVEAECADLKKNCQDVDLSLRKVEAEKNAK 987

  Fly   882 EIAEQHYRDRLHELERREIQEQLENRRRVEVNMNIINDAARKQEEPVDDGKLVEAMFDFLPDSSS 946
            |...:..:|.:.:.:....:...|.:.:.|.|..:..|....:|:.:...||...:...|.||
 Worm   988 EHQIRALQDEMRQQDENISKLNKERKNQEEQNKKLTEDLQAAEEQNLAANKLKAKLMQSLEDS-- 1050

  Fly   947 DAPTPHGGRETSVFNDLPHAQNVNQDDIIAPIHISEDEEDLSEFKFQKFAATYFQGNVNHQYAKK 1011
                     |.::..:..:..:::::...|...:...:|.|.|.            |.:...|:.
 Worm  1051 ---------EQTMEREKRNRADMDKNKRKAEGELKIAQETLEEL------------NKSKSDAEN 1094

  Fly  1012 ALKHPLLPLHTQGDQLAAQALWITILRFTGDMPEPKYHTM-DRM-DTTSVMSKVTATLGRNFIRS 1074
            ||:.....|||.|.:|..:...:..|:......|.:...: |:: |......:..        ||
 Worm  1095 ALRRKETELHTLGMKLEDEQAAVAKLQKGIQQDEARVKDLHDQLADEKDARQRAD--------RS 1151

  Fly  1075 KEFQEAQLMGLDPDAFLKQKPRSIRHKLVSLTL-KRKNKLGEDVRRRLQDDEYTADSYQSWLQSR 1138
            :..|:|:.     |...:|.....|.....:.| |:|:.....:||.|::.........:.|:.:
 Worm  1152 RADQQAEY-----DELTEQLEDQARATAAQIELGKKKDAELTKLRRDLEESGLKFGEQLTVLKKK 1211

  Fly  1139 PTSNLEKLHFIIGHGILRAELRDEIYCQICKQLTNNPLKSSHARGWILLSLCVGCFAPSEKFVNY 1203
            .:..::             ||.|:|. |:.||......:..|.:..         |..|...::.
 Worm  1212 GSDAIQ-------------ELSDQIE-QLQKQKGRIEKEKGHMQRE---------FDESSAALDQ 1253

  Fly  1204 ---LRAFIREGPPGYAPYCEERLKRTFNNGTRNQPPSWLELQATKSKKPIMLPITFMDGNTKTLL 1265
               |||.......||    |.||..             |.|:|.:..:.:.   .|:....: |.
 Worm  1254 EAKLRADQERIAKGY----EVRLLE-------------LRLKADEQSRQLQ---DFVSSKGR-LN 1297

  Fly  1266 ADSATTARELCNQLSDKIS----LKDQFGFSLYIALFDKVSSLGSGGDHVMDAISQCEQYAKEQ- 1325
            ::::..||:: .:|..||.    ||.||...|               ||   |..|.|:.::|:
 Worm  1298 SENSDLARQV-EELEAKIQAANRLKLQFSNEL---------------DH---AKRQAEEESRERQ 1343

  Fly  1326 --GAQERNAPWRLFFRKEIFAPWHEPTHDQVA-TNLIYQQVVR-GVKFGEYRCDKEEDLAMIAAQ 1386
              ....:|....|...|       |...|:|| .|...:|:.: .|:..::| .|.|...:|.|.
 Worm  1344 NLSNLSKNLARELEQLK-------ESIEDEVAGKNEASRQLSKASVELDQWR-TKFETEGLIGAD 1400

  Fly  1387 QY 1388
            ::
 Worm  1401 EF 1402

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ck	NP_523571.1	MYSc_Myo7	77..721	CDD:276832	267/698 (38%)
		MyTH4	<1138..1245	CDD:214535	21/109 (19%)
		FERM1_F1_Myosin-VII	1249..1347	CDD:340612	21/104 (20%)
		B41	1251..1467	CDD:214604	33/147 (22%)
		FERM_C1_MyoVII	1461..1559	CDD:270019
		SH3	1560..1624	CDD:473055
		MyTH4	1701..1849	CDD:214535
		FERM2_F1_Myosin-VII	1854..1951	CDD:340613
		B41	1856..2068	CDD:214604
		FERM_C2_MyoVII	2064..2159	CDD:270020
myo-2	NP_510092.2	COG5022	27..1478	CDD:227355	423/1497 (28%)
		MYSc_class_II	95..782	CDD:276951	267/698 (38%)
		SMC_prok_B	1097..1936	CDD:274008	77/390 (20%)