DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rnmt and RNMT

DIOPT Version :9

Sequence 1:	NP_523568.2	Gene:	Rnmt / 34877	FlyBaseID:	FBgn0286027	Length:	427	Species:	Drosophila melanogaster
Sequence 2:	XP_011524051.1	Gene:	RNMT / 8731	HGNCID:	10075	Length:	512	Species:	Homo sapiens

Alignment Length:	432	Identity:	171/432 - (39%)
Similarity:	256/432 - (59%)	Gaps:	41/432 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 EQNAADEQFARAHKAVSLSDDEESEGQAETTSAPNQ----EPHV--------------SKSPREY 52
            |:.:...|...|.|.....||...|..:.....|::    :|.:              .|..||.
Human    45 EKTSVCRQVDIARKRKEFEDDLVKESSSCGKDTPSKKRKLDPEIVPEEKDCGDAEGNSKKRKRET 109

  Fly    53 YDEPGGKGN-GSGADD------QDEPETEAASGAANTHVVAHHYNELKEAGRKDRQKSKIFFMRN 110
            .|.|..|.: |.|..:      :|.||.:......::..||.|||||:|.|.:.|.:|:||::||
Human   110 EDVPKDKSSTGDGTQNKRKIALEDVPEKQKNLEEGHSSTVAAHYNELQEVGLEKRSQSRIFYLRN 174

  Fly   111 FNNWIKSQLINEYMSQIKQNKRMGDALRVLDMCCGKGGDLLKWEKAAISHLICTDIAEVSVEQCQ 175
            ||||:||.||.|::.:::|.|:..  :.|||:.||||||||||:|..|:.|:|||||:|||:|||
Human   175 FNNWMKSVLIGEFLEKVRQKKKRD--ITVLDLGCGKGGDLLKWKKGRINKLVCTDIADVSVKQCQ 237

  Fly   176 RRYQDILQRSEKSKFANKFTAEFFACDSTLVRLRERYKDPSLQLNLVSCQFAFHYCFESMAQADC 240
            :||:|:..|.:....   |:|||...||:...|.::::||.:..::.||||..||.|||..|||.
Human   238 QRYEDMKNRRDSEYI---FSAEFITADSSKELLIDKFRDPQMCFDICSCQFVCHYSFESYEQADM 299

  Fly   241 MMRNAAECLKPGGFFIATMPDAYEIIRRLRAAGPDARRFGNDVYSIEFDCETDPLPLFGAKYQFH 305
            |:|||.|.|.|||:||.|.|:::|:||||.|:  :...|||::|:::|..:.| .||||.||.|:
Human   300 MLRNACERLSPGGYFIGTTPNSFELIRRLEAS--ETESFGNEIYTVKFQKKGD-YPLFGCKYDFN 361

  Fly   306 LEGVVDCPEFLVHFPTLVKLGRKYGLQLLKRSTFADYYKENL--HHGRHLLQRMSGLESVQPQR- 367
            ||||||.|||||:||.|.::.:||.::|:.:.||.::|:|.:  :..:.||:||..||......
Human   362 LEGVVDVPEFLVYFPLLNEMAKKYNMKLVYKKTFLEFYEEKIKNNENKMLLKRMQALEPYPANES 426

  Fly   368 ----CENDEEFAHVSNF-QGAQRSRSVGTLSKSEWEAATLYL 404
                .|..:::.|.:.: :.:|....:||||||||||...:|
Human   427 SKLVSEKVDDYEHAAKYMKNSQVRLPLGTLSKSEWEATRSFL 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rnmt	NP_523568.2	Pox_MCEL	72..411	CDD:281307	152/341 (45%)
RNMT	XP_011524051.1	Pox_MCEL	136..468	CDD:281307	151/339 (45%)
RNMT	XP_011524051.1	SmtA	196..414	CDD:223574	107/225 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152208
Domainoid	1	1.000	313	1.000	Domainoid score	I1302
eggNOG	1	0.900	-	-		E1_KOG1975
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H2816
Inparanoid	1	1.050	321	1.000	Inparanoid score	I2525
Isobase	1	0.950	-	0	Normalized mean entropy	S2396
OMA	1	1.010	-	-		QHG54527
OrthoDB	1	1.010	-	-		D1390749at2759
OrthoFinder	1	1.000	-	-		FOG0004895
OrthoInspector	1	1.000	-	-		oto88988
orthoMCL	1	0.900	-	-		OOG6_102244
Panther	1	1.100	-	-	LDO	PTHR12189
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R689
SonicParanoid	1	1.000	-	-		X3451
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.750