DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3491 and EMB1135

DIOPT Version :9

Sequence 1:	NP_609731.1	Gene:	CG3491 / 34870	FlyBaseID:	FBgn0028887	Length:	1801	Species:	Drosophila melanogaster
Sequence 2:	NP_178053.4	Gene:	EMB1135 / 844273	AraportID:	AT1G79350	Length:	1295	Species:	Arabidopsis thaliana

Alignment Length:	1395	Identity:	502/1395 - (35%)
Similarity:	748/1395 - (53%)	Gaps:	187/1395 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   472 PPPPLAKIPTNLTVERPHSRLSDPKKIESDIDARLQAELDSLPMVAVPADENIEPLGKTDQHFSV 536
            |||||.        .:|||....  .|..|:..|. |....:..|.....|           ||.
plant     8 PPPPLP--------AQPHSAAGG--VIRGDVQVRC-AGCRVILRVKTGVVE-----------FSC 50

  Fly   537 PT--------NKNLSENK-AFPK-PNQVCIPPQP--AIPP--QPAI-------PPAPAYCMANKT 580
            ||        .:.||..: .||: |.|   ||||  .:||  |..:       ||.||:.:....
plant    51 PTCQLPQMLPPELLSRARPQFPQSPQQ---PPQPIQTLPPPIQQQLKPLNLPRPPVPAHGIDPTK 112

  Fly   581 MDTGMSSVVQMANNPLASTQHHALPQVPIVTRLKVDQGEDVSVKFTTGLDGLITNVQLLPSTMAM 645
            |....::...:.|.|      |.|      ||....|                .:|:|
plant   113 MQLPCANCQAILNVP------HGL------TRFSCPQ----------------CHVEL------- 142

  Fly   646 GQPTVKATEL-ESFTAQQLNMLLQSGHPYLSLPMTNSGVPGAVLQETLQTKDAGFPSEQAVEDEE 709
               .|..::| .|.||.|.:    |..|..:.|.    ||.....|.:        :|:|:|.|.
plant   143 ---AVDVSKLNRSLTASQSH----SNPPTPAAPT----VPPPPPPEEV--------NEEAIEVER 188

  Fly   710 VDYEEIGVADTFAAYWPSKLKFGRAHPDPVVETATLSSVELPNINYQLALPS--KTTECLSALQL 772
            .:.|.....:||..|.|.||..|..||||:|||::||:|:.|...|.|.:..  :.::.||.||:
plant   189 EEDEGGTAGETFMDYRPPKLSIGPPHPDPIVETSSLSAVQPPEPTYDLKIKEELERSKALSCLQI 253

  Fly   773 EAVVYACQAHEQILPSGDRAGFLLGDGAGVGKGRTIAGIIFDNYLKGRKRALWVSVSSDLKFDAE 837
            |.:|||||.|.|.|..|.||||.:||||||||||||||:|::|:..||::|||:|:.||||:||.
plant   254 ETLVYACQRHLQHLADGTRAGFFVGDGAGVGKGRTIAGLIWENWKHGRRKALWISIGSDLKYDAR 318

  Fly   838 RDLADIGAHEKIRVATINKFKYSPIDSEENENFKRGVIFCTYTALIGESMTTNSKYKTRFRQLTN 902
            |||.|:|| ..:.|..:||..||.:|| :|...|.||:|.||.:||..|    .|.::|.:||..
plant   319 RDLDDVGA-TCVGVNPLNKLPYSKLDS-KNVGIKEGVVFLTYNSLIASS----EKGRSRLQQLVQ 377

  Fly   903 WLGKKFEGVIVFDECHKAKNLSLMNVGKSTKTGTTVLDLQKLLPNARVVYASATGASEPRNMAYM 967
            |.|.:|:|:::||||||||||......:.|:.|..|:|:|..:|.|||:|.|||||||||||.||
plant   378 WCGPEFDGLLIFDECHKAKNLVPEAGSQPTRIGQAVVDIQDKIPQARVIYCSATGASEPRNMGYM 442

  Fly   968 VRLGLWGPGTAYPEFYEFVNAVEKRGIGAMEIVAMDMKLRGTYIARQLSFKDVSFRIEEVNMSKE 1032
            |||||||.||::.:|.:|:.|::|.|.||:|:||||||.||.|:.|.||:|...|.|.|..:...
plant   443 VRLGLWGAGTSFSDFNKFLGALDKGGTGALELVAMDMKARGMYVCRTLSYKGAEFEIVEARLEAG 507

  Fly  1033 FRKSYNLSAELWADIHKKFQKACRLMCVENRVQKIITCQFWCAHQRFFKNLCIASKVNHVVKMTR 1097
            ....||.|||.||::..:...|...:..|......:...:|.:|||||::||:::||...|::.:
plant   508 MEAMYNKSAEFWAELRIELLSASAFLPNEKPNSSQLWRLYWSSHQRFFRHLCMSAKVPVTVRLAK 572

  Fly  1098 QATRMGKAVVIGLQSTGESRTLEHLERHHGKLNSFVSTAKMIIQSFVEKHFPAPKR-------DS 1155
            :|....|.||||||||||:||.|.:.::..:|:.|||..:.::..|||:::|.|::       ||
plant   573 KALSTNKCVVIGLQSTGEARTEEAVNKYGLELDDFVSGPRELLLKFVEENYPLPEQPEPLSEDDS 637

  Fly  1156 F------HHLLNTGEFEPEARSRPPKQKKSKMNTDWVEDDMDAEAGESDIEMYERSCTAAVEKIK 1214
            .      .|..:.|   ...|.|..|..|.|.::| .|.|:::||..:| :..:......:.:|.
plant   638 VKELQRKRHSASPG---VSIRGRVRKMAKWKPDSD-NESDLESEADSAD-DSNDSDDEFQICQIC 697

  Fly  1215 SGQKRRGRPPKADKVEKITMQERIL---------EHLCNNMREQDNEDESTNTSDNTKVKVNITE 1270
            ||:..|.:.....:.:|:...:.::         ..:|.:.:|:..|.....     ::.:...:
plant   698 SGEDERKKLLHCSECDKLFHPDCVVPPVIDLPSEAWICFSCKEKTEEYIQAR-----RLYIAELQ 757

  Fly  1271 RDVERCINMREMLLEKIDVLGRKLPPNTLDKLISELGGTNLVAEMTGRRGRVVR-TEYDGYKYEP 1334
            :..|..:..:..::|.|..|  .||.|.||.::.:|||...|||||||||.:|| :...|..|:.
plant   758 KRYEAALERKSKIIEIIRSL--NLPNNPLDDIVDQLGGPEKVAEMTGRRGMLVRASNGKGVTYQA 820

  Fly  1335 RCENDSTMDLVNYREKQRFMDGSKHVAIISEAASSGISLQSDKRVSNQRRRLHITLELPWSADRA 1399
            |...|.||::||..|||.||||.|.|||||||.|:|:|||:|:|..||:||:|:|||||||||||
plant   821 RNTKDITMEMVNMHEKQLFMDGKKLVAIISEAGSAGVSLQADRRAVNQKRRVHLTLELPWSADRA 885

  Fly  1400 IQQFGRTHRSNQVNAPEYVFVITDLAGERRFASTVAKRLESLGALTQGDRRA-TDARDLSQFNID 1463
            ||||||||||||.:||||..:.|:|.|||||||.||||||:||||||||||| .....||.:|.|
plant   886 IQQFGRTHRSNQTSAPEYRLLFTNLGGERRFASIVAKRLETLGALTQGDRRAGPSGPSLSAYNYD 950

  Fly  1464 NSIGRSAL----ENVMQQ-----LTSNKPLDRSQVPQSYKGNFIYDCCVAMAGVGMI------NV 1513
            ::.|:.:|    ..:|:|     |.....:|.   |::.| .|:.....|:..||::      |.
plant   951 SNFGKKSLMVMYRGIMEQEKLPVLPPGCSIDE---PETVK-EFLTKARAALVAVGIVRDSVLANG 1011

  Fly  1514 REENKVKVFTVEKDSNNISKFLNRILGCRVEVQNALFKFFLDKMYSLIMQMKRTGRFDLGILDLD 1578
            ::..:.....::.|.:::.:||||:||...::||.||:.|...:..|:...:..|.||.||:|:.
plant  1012 KDVGRFSGRIIDSDMHDVGRFLNRLLGLPPDIQNRLFELFTSILDVLVHNARIEGSFDSGIVDMK 1076

  Fly  1579 AHGASVKSIKLMRFIRKHATGTAATELHTVTVERGMSFETA---LAKYRKEG-QYEHEGFYILQK 1639
            |:  ||:.:...:.:.......|:|.|.|.|::||:::|:|   |...|::| ...::||:..::
plant  1077 AN--SVELLSTPKTVHVDQMSGASTMLFTFTLDRGVTWESASSMLEGKRRDGLGSANDGFFESKR 1139

  Fly  1640 RRQNKNSAILCLQAPSNSSDVSNGKINLQIYRPNTGPQVRLETHASISSRYVKVSP-EEAQTYWV 1703
            ....:...||..::.::..        .:|.||..|..:|..:.:.:.::|.|:|. |:|:|.|.
plant  1140 EWLGRRHFILAFESAASGL--------FKIVRPAVGESIREMSLSELKTKYRKLSSLEKARTGWE 1196

  Fly  1704 QQYELCLNMCSHLYWNRTCPMPTGCEVGLRMRTYHVLSGLMLPIWDRIELII---VNSGHK-IQI 1764
            .:||:....|.|   ...|.:...|.||.|::..:|:.||:||||..||..:   ....|| |::
plant  1197 DEYEVSSKQCMH---GPKCKLGEYCTVGRRIQEVNVVGGLILPIWGTIEKALSKQARHSHKRIRV 1258

  Fly  1765 IRMKTDA-NKKIVGTVVPPAVYDDLVADLS 1793
            ||::|.. |::|||..:|.|..:.::.||:
plant  1259 IRIETTTDNQRIVGLSIPNAAVETVLQDLA 1288

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3491	NP_609731.1	AAA_34	737..1038	CDD:290583	154/302 (51%)
		DEXDc	759..986	CDD:214692	120/228 (53%)
		Helicase_C_4	1297..1576	CDD:290582	140/295 (47%)
EMB1135	NP_178053.4	AAA_34	216..514	CDD:290583	155/303 (51%)
		PHD	693..741	CDD:279022	6/47 (13%)
		DUF349	739..>791	CDD:281922	11/58 (19%)
		Helicase_C_4	782..1074	CDD:290582	140/295 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	356	1.000	Domainoid score	I204
eggNOG	1	0.900	-	-		E1_KOG1513
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	836	1.000	Inparanoid score	I73
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D141580at2759
OrthoFinder	1	1.000	-	-		FOG0002373
OrthoInspector	1	1.000	-	-		oto3766
orthoMCL	1	0.900	-	-		OOG6_102140
Panther	1	1.100	-	-	O	PTHR12706
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1569
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.830