Protein Alignment CG3491 and SBNO1

DIOPT Version :10

• Sequence 1: NP_609731.1
• Gene: CG3491 / 34870
• FlyBaseID: FBgn0028887
• Length: 1801
• Species: Drosophila melanogaster
• Sequence 2: NP_001161328.1
• Gene: SBNO1 / 55206
• HGNCID: 22973
• Length: 1393
• Species: Homo sapiens
• Alignment Length: 1402
• Identity: 630/1402 - (44%)
• Similarity: 834/1402 - (59%)
• Gaps: 170/1402 - (12%)

  Fly   524 IEPLGKTDQHFSVPTNKNLSENKAF-------------PKPN-QVCIP---------PQPAIP-- 563
            :|| |: |...:..:...:|.|..|             |.|: |..:|         .:.|:|
Human     2 VEP-GQ-DLLLAALSESGISPNDLFDIDGGDAGLATPMPTPSVQQSVPLSALELGLETEAAVPVK 64

  Fly   564 PQPAIPPAPAYCMANKTMDTGMSSVVQMANN--PLASTQHHALPQVPIVTRLKVDQGEDVSVKFT 626
            .:|...|.||.....:...:..:.|:...|:  ||.||  ..:.:.|.||   .::......||
Human    65 QEPETVPTPALLNVRQQPPSTTTFVLNQINHLPPLGST--IVMTKTPPVT---TNRQTITLTKF- 123

  Fly   627 TGLDGLITNVQLLPSTMAMGQPTVK--ATELESFTAQQLNMLLQSG--HPYLSL-PMTNSGVP-- 684
                 :.|.....||..|   |||:  .|...|....||..||::.  :..:.| |..|...|
Human   124 -----IQTTASTRPSVSA---PTVRNAMTSAPSKDQVQLKDLLKNNSLNELMKLKPPANIAQPVA 180

  Fly   685 --------GAVLQETLQTKDA----------GFPSEQAV-------EDEEVDYEEIGVADTFAAY 724
                    |.|.:|:...:.|          .|.....|       |.||.|.||:|.|:|:|.|
Human   181 TAATDVSNGTVKKESSNKEGARMWINDMKMRSFSPTMKVPVVKEDDEPEEEDEEEMGHAETYAEY 245

  Fly   725 WPSKLKFGRAHPDPVVETATLSSVELPNINYQLALPSKTTE--CLSALQLEAVVYACQAHEQILP 787
            .|.|||.|..|||.||||::||||..|::.|:.::..:|.:  .||||||||:.||.|.||..||
Human   246 MPIKLKIGLRHPDAVVETSSLSSVTPPDVWYKTSISEETIDNGWLSALQLEAITYAAQQHETFLP 310

  Fly   788 SGDRAGFLLGDGAGVGKGRTIAGIIFDNYLKGRKRALWVSVSSDLKFDAERDLADIGAHEKIRVA 852
            :|||||||:||||||||||||||||::|||..||||||.|||:|||:||||||.|||| :.|.|.
Human   311 NGDRAGFLIGDGAGVGKGRTIAGIIYENYLLSRKRALWFSVSNDLKYDAERDLRDIGA-KNILVH 374

  Fly   853 TINKFKYSPIDSEENENFKRGVIFCTYTALIGESMTTNSKYKTRFRQLTNWLGKKFEGVIVFDEC 917
            ::|||||..|.|:.|.:.|:||||.||::|||||. :..|||||.:||.:|.|..|:||||||||
Human   375 SLNKFKYGKISSKHNGSVKKGVIFATYSSLIGESQ-SGGKYKTRLKQLLHWCGDDFDGVIVFDEC 438

  Fly   918 HKAKNLSLMNVGKSTKTGTTVLDLQKLLPNARVVYASATGASEPRNMAYMVRLGLWGPGTAYPEF 982
            ||||||..:...|.||||..||:||..||.||||||||||||||||||||.|||:||.||.:.||
Human   439 HKAKNLCPVGSSKPTKTGLAVLELQNKLPKARVVYASATGASEPRNMAYMNRLGIWGEGTPFREF 503

  Fly   983 YEFVNAVEKRGIGAMEIVAMDMKLRGTYIARQLSFKDVSFRIEEVNMSKEFRKSYNLSAELWADI 1047
            .:|:.|||:||:||||||||||||||.||||||||..|:|:||||.:|:.:.|.||.:.:||...
Human   504 SDFIQAVERRGVGAMEIVAMDMKLRGMYIARQLSFTGVTFKIEEVLLSQSYVKMYNKAVKLWVIA 568

  Fly  1048 HKKFQKACRLMCVENRVQKIITCQFWCAHQRFFKNLCIASKVNHVVKMTRQATRMGKAVVIGLQS 1112
            .::||:|..|:..|.|::|.:..|||.|||||||.|||||||..||::.|:..:.||.|||||||
Human   569 RERFQQAADLIDAEQRMKKSMWGQFWSAHQRFFKYLCIASKVKRVVQLAREEIKNGKCVVIGLQS 633

  Fly  1113 TGESRTLEHLERHHGKLNSFVSTAKMIIQSFVEKHFPAPKRDSFHHLLNTGEFEP----EARSRP 1173
            |||:||||.||...|:||.||||||.::||.:|||||||.|...:.||......|    ..|..|
Human   634 TGEARTLEALEEGGGELNDFVSTAKGVLQSLIEKHFPAPDRKKLYSLLGIDLTAPSNNSSPRDSP 698

  Fly  1174 PKQKKSKMN------------------TDWVEDDMDAEAGESDIEM--YERSCTAAVEKIKSG-- 1216
            .|:.|.|..                  |....||..:|:..||.|.  ||.|     :.:.||
Human   699 CKENKIKKRKGEEITREAKKARKVGGLTGSSSDDSGSESDASDNEESDYESS-----KNMSSGDD 758

  Fly  1217 ------------------------QKRRGRPPKADKVEKITMQERILEHLCNNMREQ-------- 1249
                                    .|:.....|...::..::|..:|.....:.|..
Human   759 DDFNPFLDESNEDDENDPWLIRKDHKKNKEKKKKKSIDPDSIQSALLASGLGSKRPSFSSTPVIS 823

  Fly  1250 ---DNEDESTNTSDNTKVKVNITERD-VERCINMREMLLEKIDVLGRKLPPNTLDKLISELGGTN 1310
               ::...::||:.|:.:   ||.:| |||...|::.||:|::.|...|||||||:||.||||..
Human   824 PAPNSTPANSNTNSNSSL---ITSQDAVERAQQMKKDLLDKLEKLAEDLPPNTLDELIDELGGPE 885

  Fly  1311 LVAEMTGRRGRVVRTEYDGYKYEPRCENDSTMDLVNYREKQRFMDGSKHVAIISEAASSGISLQS 1375
            .|||||||:||||..:.....||.|.|.|..::::|..||||||||.|::||||||||||||||:
Human   886 NVAEMTGRKGRVVSNDDGSISYESRSELDVPVEILNITEKQRFMDGDKNIAIISEAASSGISLQA 950

  Fly  1376 DKRVSNQRRRLHITLELPWSADRAIQQFGRTHRSNQVNAPEYVFVITDLAGERRFASTVAKRLES 1440
            |:|..|||||:|:||||||||||||||||||||||||.||||||:|::||||:||||.|||||||
Human   951 DRRAKNQRRRVHMTLELPWSADRAIQQFGRTHRSNQVTAPEYVFLISELAGEQRFASIVAKRLES 1015

  Fly  1441 LGALTQGDRRATDARDLSQFNIDNSIGRSALENVMQQLTSNKPLDRSQV--PQSYKGNFIYDCCV 1503
            |||||.||||||::||||:||.||..||:|||.||:.:.:   ||...|  |..|.|.|..|...
Human  1016 LGALTHGDRRATESRDLSRFNFDNKYGRNALEIVMKSIVN---LDSPMVSPPPDYPGEFFKDVRQ 1077

  Fly  1504 AMAGVGMINVREENKVKVFTVEKDSNNISKFLNRILGCRVEVQNALFKFFLDKMYSLIMQMKRTG 1568
            .:.|||:|||  |::..:.|::||.|||.||||||||..|..|||||::|.|.:.:::...|:.|
Human  1078 GLIGVGLINV--EDRSGILTLDKDYNNIGKFLNRILGMEVHQQNALFQYFADTLTAVVQNAKKNG 1140

  Fly  1569 RFDLGILDLDAHGASVKSIKLMRFIRKHATGTAATELHTVTVERGMSFETALAKYRKEGQYEHEG 1633
            |:|:|||||.:....|:...:.:|:....:.:...||:|::||||||:|.| .|...|.....:|
Human  1141 RYDMGILDLGSGDEKVRKSDVKKFLTPGYSTSGHVELYTISVERGMSWEEA-TKIWAELTGPDDG 1204

  Fly  1634 FYILQKRRQNKNSAILCLQAPSNSSDVSNGKINLQIYRPNTGPQVRLETHASISSRYVKVSPEEA 1698
            ||:..:.|.||.:|||.       .:|:..|....:||||||.|::||.:|.:..:|.||..::|
Human  1205 FYLSLQIRNNKKTAILV-------KEVNPKKKLFLVYRPNTGKQLKLEIYADLKKKYKKVVSDDA 1262

  Fly  1699 QTYWVQQYELCLNMCSHLYWNRTC---PMPTGCEVGLRMRTYHVLSGLMLPIWDRIELIIVN-SG 1759
            ..:|:.||....:.|:|.||...|   .:...||:|||.|||:||.|.:|.:|.::|.::.: ||
Human  1263 LMHWLDQYNSSADTCTHAYWRGNCKKASLGLVCEIGLRCRTYYVLCGSVLSVWTKVEGVLASVSG 1327

  Fly  1760 H--KIQIIRMKTDANKKIVGTVVPPAVYDDLVADLST 1794
            .  |:||:|::|:..::|||.::|......||..|||
Human  1328 TNVKMQIVRLRTEDGQRIVGLIIPANCVSPLVNLLST 1364

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3491	NP_609731.1	AAA_34	737..1038	CDD:464010	197/302 (65%)
		Helicase_C_4	1297..1576	CDD:464009	173/280 (62%)
SBNO1	NP_001161328.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	129..148		7/21 (33%)
		AAA_34	258..560	CDD:464010	198/303 (65%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	687..840		26/157 (17%)
		Helicase_C_4	872..1148	CDD:464009	173/280 (62%)