DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3491 and SBNO1

DIOPT Version :9

Sequence 1:	NP_609731.1	Gene:	CG3491 / 34870	FlyBaseID:	FBgn0028887	Length:	1801	Species:	Drosophila melanogaster
Sequence 2:	NP_001161328.1	Gene:	SBNO1 / 55206	HGNCID:	22973	Length:	1393	Species:	Homo sapiens

Alignment Length:	1402	Identity:	630/1402 - (44%)
Similarity:	834/1402 - (59%)	Gaps:	170/1402 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   524 IEPLGKTDQHFSVPTNKNLSENKAF-------------PKPN-QVCIP---------PQPAIP-- 563
            :|| |: |...:..:...:|.|..|             |.|: |..:|         .:.|:|
Human     2 VEP-GQ-DLLLAALSESGISPNDLFDIDGGDAGLATPMPTPSVQQSVPLSALELGLETEAAVPVK 64

  Fly   564 PQPAIPPAPAYCMANKTMDTGMSSVVQMANN--PLASTQHHALPQVPIVTRLKVDQGEDVSVKFT 626
            .:|...|.||.....:...:..:.|:...|:  ||.||  ..:.:.|.||   .::......||
Human    65 QEPETVPTPALLNVRQQPPSTTTFVLNQINHLPPLGST--IVMTKTPPVT---TNRQTITLTKF- 123

  Fly   627 TGLDGLITNVQLLPSTMAMGQPTVK--ATELESFTAQQLNMLLQSG--HPYLSL-PMTNSGVP-- 684
                 :.|.....||..|   |||:  .|...|....||..||::.  :..:.| |..|...|
Human   124 -----IQTTASTRPSVSA---PTVRNAMTSAPSKDQVQLKDLLKNNSLNELMKLKPPANIAQPVA 180

  Fly   685 --------GAVLQETLQTKDA----------GFPSEQAV-------EDEEVDYEEIGVADTFAAY 724
                    |.|.:|:...:.|          .|.....|       |.||.|.||:|.|:|:|.|
Human   181 TAATDVSNGTVKKESSNKEGARMWINDMKMRSFSPTMKVPVVKEDDEPEEEDEEEMGHAETYAEY 245

  Fly   725 WPSKLKFGRAHPDPVVETATLSSVELPNINYQLALPSKTTE--CLSALQLEAVVYACQAHEQILP 787
            .|.|||.|..|||.||||::||||..|::.|:.::..:|.:  .||||||||:.||.|.||..||
Human   246 MPIKLKIGLRHPDAVVETSSLSSVTPPDVWYKTSISEETIDNGWLSALQLEAITYAAQQHETFLP 310

  Fly   788 SGDRAGFLLGDGAGVGKGRTIAGIIFDNYLKGRKRALWVSVSSDLKFDAERDLADIGAHEKIRVA 852
            :|||||||:||||||||||||||||::|||..||||||.|||:|||:||||||.|||| :.|.|.
Human   311 NGDRAGFLIGDGAGVGKGRTIAGIIYENYLLSRKRALWFSVSNDLKYDAERDLRDIGA-KNILVH 374

  Fly   853 TINKFKYSPIDSEENENFKRGVIFCTYTALIGESMTTNSKYKTRFRQLTNWLGKKFEGVIVFDEC 917
            ::|||||..|.|:.|.:.|:||||.||::|||||. :..|||||.:||.:|.|..|:||||||||
Human   375 SLNKFKYGKISSKHNGSVKKGVIFATYSSLIGESQ-SGGKYKTRLKQLLHWCGDDFDGVIVFDEC 438

  Fly   918 HKAKNLSLMNVGKSTKTGTTVLDLQKLLPNARVVYASATGASEPRNMAYMVRLGLWGPGTAYPEF 982
            ||||||..:...|.||||..||:||..||.||||||||||||||||||||.|||:||.||.:.||
Human   439 HKAKNLCPVGSSKPTKTGLAVLELQNKLPKARVVYASATGASEPRNMAYMNRLGIWGEGTPFREF 503

  Fly   983 YEFVNAVEKRGIGAMEIVAMDMKLRGTYIARQLSFKDVSFRIEEVNMSKEFRKSYNLSAELWADI 1047
            .:|:.|||:||:||||||||||||||.||||||||..|:|:||||.:|:.:.|.||.:.:||...
Human   504 SDFIQAVERRGVGAMEIVAMDMKLRGMYIARQLSFTGVTFKIEEVLLSQSYVKMYNKAVKLWVIA 568

  Fly  1048 HKKFQKACRLMCVENRVQKIITCQFWCAHQRFFKNLCIASKVNHVVKMTRQATRMGKAVVIGLQS 1112
            .::||:|..|:..|.|::|.:..|||.|||||||.|||||||..||::.|:..:.||.|||||||
Human   569 RERFQQAADLIDAEQRMKKSMWGQFWSAHQRFFKYLCIASKVKRVVQLAREEIKNGKCVVIGLQS 633

  Fly  1113 TGESRTLEHLERHHGKLNSFVSTAKMIIQSFVEKHFPAPKRDSFHHLLNTGEFEP----EARSRP 1173
            |||:||||.||...|:||.||||||.::||.:|||||||.|...:.||......|    ..|..|
Human   634 TGEARTLEALEEGGGELNDFVSTAKGVLQSLIEKHFPAPDRKKLYSLLGIDLTAPSNNSSPRDSP 698

  Fly  1174 PKQKKSKMN------------------TDWVEDDMDAEAGESDIEM--YERSCTAAVEKIKSG-- 1216
            .|:.|.|..                  |....||..:|:..||.|.  ||.|     :.:.||
Human   699 CKENKIKKRKGEEITREAKKARKVGGLTGSSSDDSGSESDASDNEESDYESS-----KNMSSGDD 758

  Fly  1217 ------------------------QKRRGRPPKADKVEKITMQERILEHLCNNMREQ-------- 1249
                                    .|:.....|...::..::|..:|.....:.|..
Human   759 DDFNPFLDESNEDDENDPWLIRKDHKKNKEKKKKKSIDPDSIQSALLASGLGSKRPSFSSTPVIS 823

  Fly  1250 ---DNEDESTNTSDNTKVKVNITERD-VERCINMREMLLEKIDVLGRKLPPNTLDKLISELGGTN 1310
               ::...::||:.|:.:   ||.:| |||...|::.||:|::.|...|||||||:||.||||..
Human   824 PAPNSTPANSNTNSNSSL---ITSQDAVERAQQMKKDLLDKLEKLAEDLPPNTLDELIDELGGPE 885

  Fly  1311 LVAEMTGRRGRVVRTEYDGYKYEPRCENDSTMDLVNYREKQRFMDGSKHVAIISEAASSGISLQS 1375
            .|||||||:||||..:.....||.|.|.|..::::|..||||||||.|::||||||||||||||:
Human   886 NVAEMTGRKGRVVSNDDGSISYESRSELDVPVEILNITEKQRFMDGDKNIAIISEAASSGISLQA 950

  Fly  1376 DKRVSNQRRRLHITLELPWSADRAIQQFGRTHRSNQVNAPEYVFVITDLAGERRFASTVAKRLES 1440
            |:|..|||||:|:||||||||||||||||||||||||.||||||:|::||||:||||.|||||||
Human   951 DRRAKNQRRRVHMTLELPWSADRAIQQFGRTHRSNQVTAPEYVFLISELAGEQRFASIVAKRLES 1015

  Fly  1441 LGALTQGDRRATDARDLSQFNIDNSIGRSALENVMQQLTSNKPLDRSQV--PQSYKGNFIYDCCV 1503
            |||||.||||||::||||:||.||..||:|||.||:.:.:   ||...|  |..|.|.|..|...
Human  1016 LGALTHGDRRATESRDLSRFNFDNKYGRNALEIVMKSIVN---LDSPMVSPPPDYPGEFFKDVRQ 1077

  Fly  1504 AMAGVGMINVREENKVKVFTVEKDSNNISKFLNRILGCRVEVQNALFKFFLDKMYSLIMQMKRTG 1568
            .:.|||:|||  |::..:.|::||.|||.||||||||..|..|||||::|.|.:.:::...|:.|
Human  1078 GLIGVGLINV--EDRSGILTLDKDYNNIGKFLNRILGMEVHQQNALFQYFADTLTAVVQNAKKNG 1140

  Fly  1569 RFDLGILDLDAHGASVKSIKLMRFIRKHATGTAATELHTVTVERGMSFETALAKYRKEGQYEHEG 1633
            |:|:|||||.:....|:...:.:|:....:.:...||:|::||||||:|.| .|...|.....:|
Human  1141 RYDMGILDLGSGDEKVRKSDVKKFLTPGYSTSGHVELYTISVERGMSWEEA-TKIWAELTGPDDG 1204

  Fly  1634 FYILQKRRQNKNSAILCLQAPSNSSDVSNGKINLQIYRPNTGPQVRLETHASISSRYVKVSPEEA 1698
            ||:..:.|.||.:|||.       .:|:..|....:||||||.|::||.:|.:..:|.||..::|
Human  1205 FYLSLQIRNNKKTAILV-------KEVNPKKKLFLVYRPNTGKQLKLEIYADLKKKYKKVVSDDA 1262

  Fly  1699 QTYWVQQYELCLNMCSHLYWNRTC---PMPTGCEVGLRMRTYHVLSGLMLPIWDRIELIIVN-SG 1759
            ..:|:.||....:.|:|.||...|   .:...||:|||.|||:||.|.:|.:|.::|.::.: ||
Human  1263 LMHWLDQYNSSADTCTHAYWRGNCKKASLGLVCEIGLRCRTYYVLCGSVLSVWTKVEGVLASVSG 1327

  Fly  1760 H--KIQIIRMKTDANKKIVGTVVPPAVYDDLVADLST 1794
            .  |:||:|::|:..::|||.::|......||..|||
Human  1328 TNVKMQIVRLRTEDGQRIVGLIIPANCVSPLVNLLST 1364

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3491	NP_609731.1	AAA_34	737..1038	CDD:290583	197/302 (65%)
		DEXDc	759..986	CDD:214692	150/228 (66%)
		Helicase_C_4	1297..1576	CDD:290582	173/280 (62%)
SBNO1	NP_001161328.1	Metaviral_G	<26..151	CDD:118131	30/138 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	129..148		7/21 (33%)
		AAA_34	258..560	CDD:290583	198/303 (65%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	687..840		26/157 (17%)
		Helicase_C_4	872..1148	CDD:290582	173/280 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D112455at33208
OrthoFinder	1	1.000	-	-		FOG0002373
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102140
Panther	1	1.100	-	-	O	PTHR12706
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1569
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.920