DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3491 and Sbno1

DIOPT Version :9

Sequence 1:	NP_609731.1	Gene:	CG3491 / 34870	FlyBaseID:	FBgn0028887	Length:	1801	Species:	Drosophila melanogaster
Sequence 2:	NP_001074672.1	Gene:	Sbno1 / 243272	MGIID:	2384298	Length:	1391	Species:	Mus musculus

Alignment Length:	1442	Identity:	626/1442 - (43%)
Similarity:	831/1442 - (57%)	Gaps:	207/1442 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   460 DSLFTTD----ELACPPPP------PLAKIPTNLTVERPHSRLSDPKKIESDIDARLQAELDSLP 514
            :.||..|    .||.|.||      ||:.:...|..|
Mouse    21 NDLFDVDGGDAGLATPTPPSVQQSVPLSALELGLETE---------------------------- 57

  Fly   515 MVAVPADENIEPLGKTDQHFSVPTNKNLSENKAFPKPNQVCIPPQPAIPPQPAIPPAPAYCMANK 579
             .|||..:..||:       |.|...|:.:.                       ||:....:.|:
Mouse    58 -AAVPVKQEPEPM-------STPALLNVRQQ-----------------------PPSTTTFVLNQ 91

  Fly   580 --TMDTGMSSVVQMANNPLASTQHHALPQVPIVTRLKVDQGEDVSVKFTTGLDGLITNVQLLPST 642
              .:.| :.|.:.|...|.|:|....      :|..|..|                |.....||.
Mouse    92 INQLPT-LGSTIVMTKTPPATTNRQT------ITLTKFIQ----------------TTANTRPSV 133

  Fly   643 MA-------MGQPTVKATELESFTA-QQLNMLLQSGHP-YLSLPMTNSGVP---GAVLQETLQTK 695
            .|       ...|:....:|:.... ..||.|::...| .::.|:..:...   |||.:|:...:
Mouse   134 SAPAVRNAMPAAPSKDQVQLKDLLKNNSLNELMKLKPPANIAQPVATAATDVSNGAVKKESSNKE 198

  Fly   696 DA----------GFPSEQAV-------EDEEVDYEEIGVADTFAAYWPSKLKFGRAHPDPVVETA 743
            .|          .|.....|       |.||.|.||:|.|:|:|.|.|.|||.|..|||.||||:
Mouse   199 VARIWINDMKMRSFSPTMKVPVVKEEDEPEEEDEEEMGHAETYAEYMPIKLKIGLRHPDAVVETS 263

  Fly   744 TLSSVELPNINYQLALPSKTTE--CLSALQLEAVVYACQAHEQILPSGDRAGFLLGDGAGVGKGR 806
            :||||..|::.|:.::..:|.:  .|||||||||.||.|.||..||:|||||||:||||||||||
Mouse   264 SLSSVTPPDVWYKTSISEETIDNGWLSALQLEAVTYAAQQHETFLPNGDRAGFLIGDGAGVGKGR 328

  Fly   807 TIAGIIFDNYLKGRKRALWVSVSSDLKFDAERDLADIGAHEKIRVATINKFKYSPIDSEENENFK 871
            ||||||::|||..||||||.|||:|||:||||||.|||| :.|.|.::|||||..|.|:.|.:.|
Mouse   329 TIAGIIYENYLLSRKRALWFSVSNDLKYDAERDLRDIGA-KNILVHSLNKFKYGKISSKHNGSVK 392

  Fly   872 RGVIFCTYTALIGESMTTNSKYKTRFRQLTNWLGKKFEGVIVFDECHKAKNLSLMNVGKSTKTGT 936
            :||||.||::|||||. :..|||||.:||.:|.|..|:||||||||||||||..:...|.||||.
Mouse   393 KGVIFATYSSLIGESQ-SGGKYKTRLKQLLHWCGDDFDGVIVFDECHKAKNLCPVGSSKPTKTGL 456

  Fly   937 TVLDLQKLLPNARVVYASATGASEPRNMAYMVRLGLWGPGTAYPEFYEFVNAVEKRGIGAMEIVA 1001
            .||:||..||.||||||||||||||||||||.|||:||.||.:.||.:|:.|||:||:|||||||
Mouse   457 AVLELQNKLPKARVVYASATGASEPRNMAYMNRLGIWGEGTPFREFSDFIQAVERRGVGAMEIVA 521

  Fly  1002 MDMKLRGTYIARQLSFKDVSFRIEEVNMSKEFRKSYNLSAELWADIHKKFQKACRLMCVENRVQK 1066
            |||||||.||||||||..|:|:||||.:|:.:.|.||.:.:||....::||:|..|:..|.|::|
Mouse   522 MDMKLRGMYIARQLSFTGVTFKIEEVLLSQSYVKMYNKAVKLWVIARERFQQAADLIDAEQRMKK 586

  Fly  1067 IITCQFWCAHQRFFKNLCIASKVNHVVKMTRQATRMGKAVVIGLQSTGESRTLEHLERHHGKLNS 1131
            .:..|||.|||||||.|||||||..||::.|:..:.||.||||||||||:||||.||...|:||.
Mouse   587 SMWGQFWSAHQRFFKYLCIASKVKRVVQLAREEIKNGKCVVIGLQSTGEARTLEALEEGGGELND 651

  Fly  1132 FVSTAKMIIQSFVEKHFPAPKRDSFHHLLNTGEFEP----EARSRPPKQKKSKMN---------- 1182
            ||||||.::||.:|||||||.|...:.||......|    ..|..|.|:.|.|..
Mouse   652 FVSTAKGVLQSLIEKHFPAPDRKKLYSLLGIDLTAPSNNSSPRDSPCKENKIKKRKGEEITREAK 716

  Fly  1183 --------TDWVEDDMDAEA----GESDIEMYERSCTAAVEK------------------IKSGQ 1217
                    |....||..:|:    .|||.|..:...:...:.                  |:...
Mouse   717 KARKVGGLTGSSSDDSGSESVSDNDESDYESSKNMSSGDDDDFNPFRDESSEDNEDDPWLIRKDH 781

  Fly  1218 KRRGRPPKADKVEKITMQERILEHLCNNMR-----------EQDNEDESTNTSDNTKVKVNITER 1271
            |:.....|...::..::|..:|.....:.|           ..::...::|::.|:.:   :|.:
Mouse   782 KKSKDKKKKKSIDPDSIQSALLASGLGSKRPSFSSAPVISPASNSAPANSNSNSNSSL---VTSQ 843

  Fly  1272 D-VERCINMREMLLEKIDVLGRKLPPNTLDKLISELGGTNLVAEMTGRRGRVVRTEYDGYKYEPR 1335
            | |||...|::.||:|::.|...|||||||:||.||||...|||||||:||||..:.....||.|
Mouse   844 DAVERAQQMKKDLLDKLEKLAEDLPPNTLDELIDELGGPENVAEMTGRKGRVVSNDDGSISYESR 908

  Fly  1336 CENDSTMDLVNYREKQRFMDGSKHVAIISEAASSGISLQSDKRVSNQRRRLHITLELPWSADRAI 1400
            .|.|..::::|..||||||||.|::||||||||||||||:|:|..|||||:|:||||||||||||
Mouse   909 SELDVPVEILNITEKQRFMDGDKNIAIISEAASSGISLQADRRAKNQRRRVHMTLELPWSADRAI 973

  Fly  1401 QQFGRTHRSNQVNAPEYVFVITDLAGERRFASTVAKRLESLGALTQGDRRATDARDLSQFNIDNS 1465
            ||||||||||||.||||||:|::||||:||||.||||||||||||.||||||::||||:||.||.
Mouse   974 QQFGRTHRSNQVTAPEYVFLISELAGEQRFASIVAKRLESLGALTHGDRRATESRDLSRFNFDNK 1038

  Fly  1466 IGRSALENVMQQLTSNKPLDRSQV--PQSYKGNFIYDCCVAMAGVGMINVREENKVKVFTVEKDS 1528
            .||:|||.||:.:.:   ||...|  |..|.|.|..|....:.|||:|||  |::..:.|::||.
Mouse  1039 YGRNALEIVMKSIVN---LDSPMVSPPPDYPGEFFKDVRQGLIGVGLINV--EDRSGILTLDKDY 1098

  Fly  1529 NNISKFLNRILGCRVEVQNALFKFFLDKMYSLIMQMKRTGRFDLGILDLDAHGASVKSIKLMRFI 1593
            |||.||||||||..|..|||||::|.|.:.:::...|:.||:|:|||||.:....|:...:.:|:
Mouse  1099 NNIGKFLNRILGMEVHQQNALFQYFADTLTAVVQNAKKNGRYDMGILDLGSGDEKVRKSDVKKFL 1163

  Fly  1594 RKHATGTAATELHTVTVERGMSFETALAKYRKEGQYEHEGFYILQKRRQNKNSAILCLQAPSNSS 1658
            ....:.:...||:|::||||||:|.| .|...|.....:|||:..:.|.||.:|||.       .
Mouse  1164 TPGYSTSGHVELYTISVERGMSWEEA-TKIWAELTGPDDGFYLSLQIRNNKKTAILV-------K 1220

  Fly  1659 DVSNGKINLQIYRPNTGPQVRLETHASISSRYVKVSPEEAQTYWVQQYELCLNMCSHLYWNRTC- 1722
            :|:..|....|||||||.|::||.:|.:..:|.||..::|..:|:.||....:.|:|.||...|
Mouse  1221 EVNPKKKLFLIYRPNTGKQLKLEIYADLKKKYKKVVSDDALVHWLDQYNSSADTCTHAYWRGNCK 1285

  Fly  1723 --PMPTGCEVGLRMRTYHVLSGLMLPIWDRIELIIVN-SGH--KIQIIRMKTDANKKIVGTVVPP 1782
              .:...||:|||.|||:||.|.:|.:|.::|.::.: ||.  |:||:|::|:..::|||.::|.
Mouse  1286 KASLGLVCEIGLRCRTYYVLCGSVLSVWTKVEGVLASVSGTNVKMQIVRLRTEDGQRIVGLIIPA 1350

  Fly  1783 AVYDDLVADLST 1794
            .....||..|||
Mouse  1351 NCVSPLVNLLST 1362

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3491	NP_609731.1	AAA_34	737..1038	CDD:290583	198/302 (66%)
		DEXDc	759..986	CDD:214692	151/228 (66%)
		Helicase_C_4	1297..1576	CDD:290582	173/280 (62%)
Sbno1	NP_001074672.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	21..43		8/21 (38%)
		AAA_34	257..559	CDD:372772	199/303 (66%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	686..847		24/163 (15%)
		Helicase_C_4	870..1146	CDD:372771	173/280 (62%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	873..892		13/18 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	144	1.000	Domainoid score	I4592
eggNOG	1	0.900	-	-		E1_KOG1513
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002373
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102140
Panther	1	1.100	-	-	O	PTHR12706
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1569
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	9	8.770