Protein Alignment: CG3491 and let-765

• Sequence 1: NP_609731.1
• Gene: CG3491
• FlyBaseID: FBgn0028887
• Length: 1801
• Species: Drosophila melanogaster
• Sequence 2: NP_498455.2
• Gene: let-765
• WormBaseID: WBGene00002889
• Length: 1866
• Species: Caenorhabditis elegans
• Alignment Length: 2000
• Identity: 685/2000 (34%)
• Similarity: 950/2000 (48%)
• Gaps: 443/2000 (22%)

  Fly    74 QKSQLMTESAGKFDSETKRKRQATVSGSKSQLLDELASDSDN---YVKQLRTFLRSTSNTD---- 131
            |.|...:.|....|...:.....|.:.|.||..||.::||.:   |...:.|...||.:..
 Worm    20 QSSPTPSTSGSIHDDAGQSFSNNTHTPSVSQFFDETSNDSHSSSAYYTPMATPFVSTEDGGVPTS 84

  Fly   132 ----DEQKRDSPARQSRSRSRRRCTQKNENLDE-PDQNTIFKKPEVSSKINLEKHNQRTSTDKEK 191
                ||:........:..      |..:.|:|. .|.......|.|  |:...||...|....|.
 Worm    85 FFGMDEEDGGCTIMTTAG------TSGSNNIDGIEDAGGGMYYPHV--KVIPRKHTAPTVNQSEP 141

  Fly   192 QYKGQKLNSSIESIL---NVYDELPSHSDNQALNLSQKRNNAWTTKLPESSPKNIPKKNFDSKSS 253
            ......:....|..|   |..|. |:.|.:.:...|.:.|:....:...|..:| |.....::|:
 Worm   142 STPTVTIVPKKEDPLFETNTADS-PTPSGDTSTTASYEGNDGLEDQETTSDRQN-PMFVQTARST 204

  Fly   254 D--LEEAEEK--------TYLKRQSERNFYSGYRSESEGTNITPAKRS-KAQINSIPKLEYSTTY 307
            |  |:.....        :.|.::|..:  |...|.||||.:.|.|:. .....||.|....|..
 Worm   205 DGRLDTPSTSATVSPHITSSLTQRSHTS--SPASSASEGTVVPPRKKGLPITTGSIVKRTVQTKD 267

  Fly   308 G-QAQNL--VVSENANITQKPSSDIKSR--YRSTEYNQINKPDSQQPINYAHQKEETIDRRREMH 367
            | |.|.|  .|:||.....|..|.:.:.  .|.|....:.:..|            ||.|...|.
 Worm   268 GLQTQYLKAFVNENGEKIYKLLSPVAASAVARGTLPPGMGRGGS------------TIGRGGTMV 320

  Fly   368 MRKEHQ--YVDNHLNNPAQNKPDRTVSFLEMLSQAEAKKESN--QGAKKPTVNKV--SNVSQYLI 426
            .:...:  .|.||:.      |:..:....|:|.|..:..:|  ||..:|....|  ||...:|:
 Worm   321 NKNGERLMVVKNHVG------PNGQMLVKRMVSPAGTRIVANGGQGRGQPIYRAVDGSNGPTHLL 379

  Fly   427 DLGFTAGSPNHDSN--------------SNDGNDEQDNIDRRLNADLDSLFTTDELACPPPPPLA 477
            ....|.|.|...:.              ...||..:.|:..|....
 Worm   380 RRTTTTGQPTRGAPVGMAARHAVRGGTVYGGGNGYRVNLVGRGTGG------------------- 425

  Fly   478 KIPTNLTVERPHSRLSDPKKIESDIDARLQAELDSLPMVAVPADENIEPLGK----------TDQ 532
               :.:...:|.:|:|                          :..::.|:|:          ..|
 Worm   426 ---STMVHHQPLNRIS--------------------------SQRSVAPVGRVLNRGALRNGAQQ 461

  Fly   533 HFSVPTNK---NLSENKAFPKPNQVCIPPQPAIP-----------PQPAIPP-APAYCMANK-TM 581
            ...|.|:.   :..|.:..|..|.:.|  |...|           .|.:.|. .||..:.|: :.
 Worm   462 PLHVSTSSPAFHYMEEQPSPTTNGMVI--QAKTPGAGVIQARHMQSQQSFPSGGPARVLMNRSST 524

  Fly   582 DTGMSSVVQMANNPLASTQHHALPQVPIVTRLKVDQGEDVSVKFTTGLDGLITNVQLLPST---- 642
            :.|:|.:|       .......||..|                     :|.:    ::|||
 Worm   525 NAGLSRMV-------GGGYDQQLPTAP---------------------NGRL----MIPSTAVRV 557

  Fly   643 --MAMGQPTVKATELESFTAQ----QLNMLLQSGHPYLSLPMTNSGVPGAVLQETLQTKDAGFPS 701
              ..|..|.::.|......:|    ::.|..|.|.                 :|.||
 Worm   558 PGSGMASPRLQTTPQPLTKSQKAKDEMKMAYQVGR-----------------EEALQ-------- 597

  Fly   702 EQAVEDEEVDYEEIGVADTFAAYWPSKLKFGRAHPDPVVETATLSSVELPNINYQLALPSKTTEC 766
             |...|.|.|.|.:|.|:|::.|.|:||:.|.||||.|||:|:||||..|::.||:::|....:.
 Worm   598 -QRRNDLEDDEENLGYAETYSEYTPAKLRSGMAHPDSVVESASLSSVSPPDVKYQISIPEYLIDM 661

  Fly   767 --LSALQLEAVVYACQAHEQILPSGDRAGFLLGDGAGVGKGRTIAGIIFDNYLKGRKRALWVSVS 829
              :||||||||:||||.||:.:|||:|.|:|:|||||||||||:|.|||:|||:|||||:|:|||
 Worm   662 GHISALQLEAVIYACQMHERRMPSGERYGYLIGDGAGVGKGRTVACIIFENYLQGRKRAIWLSVS 726

  Fly   830 SDLKFDAERDLADIGAHEKIRVATINKFKYSPIDSEENENFKRGVIFCTYTALIGESMTTNS-KY 893
            |||||||||||.|.|| ..|.|..:||.||:.|..:||.:.|:||:|.|||:||||.....| ||
 Worm   727 SDLKFDAERDLRDCGA-PNIPVYALNKMKYAKISGKENGSIKKGVMFATYTSLIGECRGAKSRKY 790

  Fly   894 KTRFRQLTNWLGKKFEGVIVFDECHKAKNLSLMNVGKSTKTGTTVLDLQKLLPNARVVYASATGA 958
            ::|..||..|.|:.::|||:.||||:||||......|.||||..||:|||.||||||||||||||
 Worm   791 RSRISQLIQWFGQDYDGVIILDECHRAKNLVPTAGAKPTKTGRMVLELQKALPNARVVYASATGA 855

  Fly   959 SEPRNMAYMVRLGLWGPGTAYPEFYEFVNAVEKRGIGAMEIVAMDMKLRGTYIARQLSFKDVSFR 1023
            :||||||||.||||||...|:|||::|::|||:||:|||||||||||.||.|:||||||:.|||.
 Worm   856 TEPRNMAYMTRLGLWGERQAFPEFHDFISAVERRGVGAMEIVAMDMKQRGLYLARQLSFRGVSFA 920

  Fly  1024 IEEVNMSKEFRKSYNLSAELWADIHKKFQKACRLMCVENR-VQKIITCQFWCAHQRFFKNLCIAS 1087
            ::||.:|.||.|.|:.:.:||.:..::||.....|..|.| ..|.:..|||..||||||.||||:
 Worm   921 VQEVQLSSEFVKMYDAAVKLWMEARRQFQTVIETMDEEERSTCKTVWGQFWACHQRFFKYLCIAA 985

  Fly  1088 KVNHVVKMTRQATRMGKAVVIGLQSTGESRTLEHLERHHGKLNSFVSTAKMIIQSFVEKHFPAP- 1151
            ||:..|:::|:|.:..|.|||||||||||.|||.||...|:||.||||||.::...::||||..
 Worm   986 KVDTCVQLSREAIKAKKCVVIGLQSTGESATLETLEEMGGELNEFVSTAKTVLYGLIDKHFPTDA 1050

  Fly  1152 -----KRDSFHHLLNTGEFEPEARSRPPKQKKSKM------------------------------ 1181
                 .||.|.   :..:||     ||.|::|::.
 Worm  1051 SFSMGDRDIFK---DFDDFE-----RPAKRRKTRETLSFLGDVGFDTWTGVTTGMGGRVGDGVTK 1107

  Fly  1182 -------------------NT-----------------DWVEDDMDAE-AGES-DIEM------- 1201
                               ||                 |.||:||.:| .||| |:|.
 Worm  1108 NITRGLSGIGRSSMSSSTGNTNNEDANSTTSESSDGSDDEVENDMISENGGESGDLESAREEAEG 1172

  Fly  1202 -------------------YERSCTAAVEKI------------KSGQKR---------------- 1219
                               .|.|...:.|::            |||:..
 Worm  1173 ARTLEDGEQDEWVKALLAEAESSSDDSDEEVVKDEDEDEEAESKSGETHEQEEEFNPFMCDFTND 1237

  Fly  1220 ----------RGRPPKADKVEKITMQERILEHLCNNMREQDN-------------EDESTNTSDN 1261
                      ...|.|..|.:|....|...|.|...:|:::.             |.|....::.
 Worm  1238 DPWAHNQQIVEDTPQKDRKAKKRKRDEEEAERLREKVRKREERREKKRRRAIRRAEREKQRRNEE 1302

  Fly  1262 TKVKVNIT--------------ERDVERCINMREMLLEKIDVLGRKLPPNTLDKLISELGGTNLV 1312
            .:.:.:.|              |:|....:.::..||..::.|...||.||||:||.|:||...|
 Worm  1303 LQARGSATDFITSSRICGNGSGEQDDINPMLIKTELLAAVERLAPSLPANTLDQLIDEMGGPEYV 1367

  Fly  1313 AEMTGRRGRVVRTEYDGYKYEPRCEN-DSTMDLVNYREKQRFMDGSKHVAIISEAASSGISLQSD 1376
            ||||||||.:|.:|.....|:.|..| :.:::|:|..||::||.|.|.:||||||||||||||||
 Worm  1368 AEMTGRRGHMVTSETGDVMYQRRNANAEVSLELINMEEKEKFMRGEKLIAIISEAASSGISLQSD 1432

  Fly  1377 KRVSNQRRRLHITLELPWSADRAIQQFGRTHRSNQVNAPEYVFVITDLAGERRFASTVAKRLESL 1441
            :|..|:|||:|||||||||||:||||||||||||||:.|||||:|::||||:||||.||||||||
 Worm  1433 RRAINKRRRVHITLELPWSADKAIQQFGRTHRSNQVSGPEYVFLISELAGEKRFASIVAKRLESL 1497

  Fly  1442 GALTQGDRRATDARDLSQFNIDNSIGRSALENVMQQLTSNKPLDRSQVPQSYK-GNFIYDCCVAM 1505
            ||||.||||||:.|||||||:||..||.||:.:::.:...........|:.|| |.|..|..:.|
 Worm  1498 GALTHGDRRATETRDLSQFNMDNKYGRVALDTLLKTVIGQAGTPLIDPPKDYKAGEFFEDMRLYM 1562

  Fly  1506 AGVGMINVREENKVKVFTVEKDSNNISKFLNRILGCRVEVQNALFKFFLDKMYSLIMQMKRTGRF 1570
            .|||::   .:||...:|:||::..|.||||||||..|..||:||.:|.:.:..||.|.|..|.:
 Worm  1563 EGVGLL---AKNKTGQYTIEKEAATIPKFLNRILGLPVHAQNSLFHYFSEIVAELIAQSKHDGTY 1624

  Fly  1571 DLGILDLDAHGASVKSIKLMRFIRKHATGTAATELHTVTVERGMSFETALAKYRKEGQYEHEGFY 1635
            |.||:||......|:.::...|..:...|:...|:|.:.||||:|:|.|: :..||...:.:|||
 Worm  1625 DTGIMDLGTGDDQVRKLETRVFTGRVDNGSFRVEIHKIGVERGVSWEEAM-ELHKEHSNDDDGFY 1688

  Fly  1636 ILQKRRQNKNSAILCLQAPSNSSDVSN--------GKINLQ-------IYRPNTGPQVRLETHAS 1685
            |             |....:|:::...        |||.:.       |.||:||...:|.|.|.
 Worm  1689 I-------------CHPGGANTANTKKVAALVYGIGKIRMDNGARLYAITRPSTGRSPKLMTMAD 1740

  Fly  1686 ISSRYVKVSPEEAQTYWVQQYELCLNMCSHLYWNRTCPMP---TGCEVGLRMRTYHVLSGLMLPI 1747
            :|.|:.|||.:||:..|.|||:...|||.|.|....|...   |.||||.|.|||.||||.:|.:
 Worm  1741 LSKRFHKVSIDEAKEVWKQQYDSAANMCQHNYVYGKCRTESNGTYCEVGRRTRTYFVLSGSVLSV 1805

  Fly  1748 WDRIELIIVNSGHK---IQIIRMKTDANKKIVGTVVPPAVYDDLVADLST 1794
            |..:|.::..|..|   :|:||::|:.::||||.:|.|.....||..|.|
 Worm  1806 WPIVEEVLAGSDRKSSRMQVIRVRTEQDQKIVGLLVLPTHVRHLVQQLET 1855

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3491	NP_609731.1	AAA_34	737..1038	CDD:290583	191/304 (63%)
		DEXDc	759..986	CDD:214692	144/230 (63%)
		Helicase_C_4	1297..1576	CDD:290582	160/281 (57%)
let-765	NP_498455.2	AAA_34	632..936	CDD:290583	191/305 (63%)
		Helicase_C_4	1352..1630	CDD:290582	160/281 (57%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930				C133411321
eggNOG	1	0.900				E1_KOG1513
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010				D112455at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000				T374919
orthoMCL	1	0.900				OOG5_129178
Panther	1	1.100			O	PTHR12706
Phylome	1	0.910		0.750	Consistency score
RoundUp	0	0.000	Not matched by this tool.
TreeFam	1	0.960
	8	7.710