DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3491 and si:ch73-63e15.2

DIOPT Version :9

Sequence 1:	NP_609731.1	Gene:	CG3491 / 34870	FlyBaseID:	FBgn0028887	Length:	1801	Species:	Drosophila melanogaster
Sequence 2:	XP_001342116.5	Gene:	si:ch73-63e15.2 / 100002292	ZFINID:	ZDB-GENE-091204-463	Length:	1452	Species:	Danio rerio

Alignment Length:	1285	Identity:	553/1285 - (43%)
Similarity:	744/1285 - (57%)	Gaps:	168/1285 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   564 PQPAIPPA-PAYCMANK----------TMDTGMSSVVQMANNPLASTQHHALPQVPIVTRLKVDQ 617
            |..:|||| ..:..:|.          .:.|.||.|  .|||      |.:.|..|....... |
Zfish     2 PSLSIPPAMDGHSFSNSVGPQLDARGFVLATPMSHV--FANN------HWSFPNQPFGLPCPA-Q 57

  Fly   618 GEDVSVKFTTGLDGLITNVQLLP--------STMAMGQPTVKATELESFTAQQLNMLLQSGHPYL 674
            .|:....| .|:..:.|:  |||        |.:.:.|......:...|:.|..::...:...:|
Zfish    58 SENQQSCF-NGVSDMHTD--LLPQDLSNFDFSGLDLPQDLSCLDDQLIFSPQNDSLSEYASTNFL 119

  Fly   675 SLPMTNSGVP-------GAVLQET------LQTKD-----------AGF--PSEQAVEDEEVDY- 712
            :..|..: ||       .|.:||:      |.:.|           .|:  |..|..|:||||.
Zfish   120 NADMAPT-VPTIWDIKTPAPVQESSNRFQGLNSLDDISAIINTPPIGGYQRPQTQPEEEEEVDVE 183

  Fly   713 --EEIGVADTFAAYWPSKLKFGRAHPDPVVETATLSSVELPNINYQLALPSKTTE--CLSALQLE 773
              ||:|..||:|.|.|||.|.|.:|||.||||.|||||..|:|.|.|::|..|.:  .|||||||
Zfish   184 EAEELGHVDTYADYKPSKSKIGISHPDRVVETNTLSSVPPPDITYTLSIPEDTIKDGLLSALQLE 248

  Fly   774 AVVYACQAHEQILPSGDRAGFLLGDGAGVGKGRTIAGIIFDNYLKGRKRALWVSVSSDLKFDAER 838
            |:.||||.||.||.:..|||||:|||||||||||:||||.:|.|||||:|||.|||:|||:||||
Zfish   249 AITYACQQHEVILQNSQRAGFLIGDGAGVGKGRTVAGIILENNLKGRKKALWFSVSNDLKYDAER 313

  Fly   839 DLADIGAHEKIRVATINKFKYSPIDSEENENFKRGVIFCTYTALIGESMTTNSKYKTRFRQLTNW 903
            ||.|||| ..|||..:||.||....:.|      ||:|.||:||||||. ...:::||.:|:.:|
Zfish   314 DLQDIGA-VSIRVHALNKIKYGDTATSE------GVLFVTYSALIGESQ-AGGQHRTRLKQILDW 370

  Fly   904 LGKKFEGVIVFDECHKAKNLSLMNVGKSTKTGTTVLDLQKLLPNARVVYASATGASEPRNMAYMV 968
            ...:|:|||:|||||||||.:      |||.|..|||||..||.||||||||||||||:||.||.
Zfish   371 CEPEFDGVIIFDECHKAKNAT------STKMGKAVLDLQNKLPLARVVYASATGASEPKNMIYMS 429

  Fly   969 RLGLWGPGTAYPEFYEFVNAVEKRGIGAMEIVAMDMKLRGTYIARQLSFKDVSFRIEEVNMSKEF 1033
            |||:||.||.:..|.:|::.:||||:|||||||||||:.|.||||||||..|||||||:::..:|
Zfish   430 RLGIWGEGTPFRTFDDFLHTIEKRGVGAMEIVAMDMKVSGMYIARQLSFSGVSFRIEEISLDNDF 494

  Fly  1034 RKSYNLSAELWADIHKKFQKACRLMCVENRVQKIITCQFWCAHQRFFKNLCIASKVNHVVKMTRQ 1098
            :..||.:|:|||:..:.|.:|...:|:.:|  |.:..|||.:||||||.||||:||..:|::.::
Zfish   495 KLVYNKAAKLWAEALRVFMQAADELCMSSR--KSLWGQFWSSHQRFFKYLCIAAKVRCLVELAKK 557

  Fly  1099 ATRMGKAVVIGLQSTGESRTLEHLERHHGKLNSFVSTAKMIIQSFVEKHFPAPKRDSFHHLLNTG 1163
            ....||.||||||||||:||.|.|:.:.|.|:.|||.|:.:.||.|.||||:.|:.......|..
Zfish   558 ELEAGKCVVIGLQSTGEARTREVLDENDGHLDRFVSAAEGVFQSLVFKHFPSEKQMREKGAGNKR 622

  Fly  1164 EFEPEAR-SRPPKQKKSKMNTDW----VEDDMDAEAGESDIEMYERSCTAAVEKIKSGQKRRGRP 1223
            :.:|.|| |:.|:|     .||.    :.||...|:     ::.:....::.:.|
Zfish   623 KRKPRARQSKQPRQ-----GTDIAVINISDDSSTES-----DVMDSDSNSSPDSI---------- 667

  Fly  1224 PKADKVEKITMQERILEHLCNNMREQDNEDESTNTSDNTKVKVNITERDVERCINMREMLLEKID 1288
                                     |||.|:        .:.|:.|.....|..:|::.||.||.
Zfish   668 -------------------------QDNNDD--------VIFVDQTSYQKARLEDMKQGLLNKIA 699

  Fly  1289 VLGRKLPPNTLDKLISELGGTNLVAEMTGRRGRVVRTEYDGYKYEPRCENDSTMDLVNYREKQRF 1353
            .||::||.||||:||.:.||...|:|||||:|||||......:||.|.|...|:|.:|.:||.||
Zfish   700 ELGKELPLNTLDELIDKFGGPEKVSEMTGRKGRVVRRPDGSVQYESRAEQGHTIDQINIKEKDRF 764

  Fly  1354 MDGSKHVAIISEAASSGISLQSDKRVSNQRRRLHITLELPWSADRAIQQFGRTHRSNQVNAPEYV 1418
            |:|.|.|||||||||||||||:|:||.||.||:|:|||||||||||||||||||||||||||||:
Zfish   765 MNGEKLVAIISEAASSGISLQADRRVKNQCRRVHMTLELPWSADRAIQQFGRTHRSNQVNAPEYI 829

  Fly  1419 FVITDLAGERRFASTVAKRLESLGALTQGDRRATDARDLSQFNIDNSIGRSALE----NVMQQLT 1479
            |:|::|||||||||.||||||||||||.||||||::||||::|.:|..|..||:    .::.|..
Zfish   830 FLISELAGERRFASIVAKRLESLGALTHGDRRATESRDLSKYNFENKYGTKALDKITKTILGQTE 894

  Fly  1480 SNKPLDRSQVPQSYKGN---FIYDCCVAMAGVGMINVREENKVKVFTVEKDSNNISKFLNRILGC 1541
            |..|     .|:.|.|.   |..|....|..|||:  ..::::.: .:|||. ||:||||||||.
Zfish   895 SKVP-----PPKDYPGGEAMFFRDMKYGMMDVGML--CSQSRLGI-NIEKDC-NITKFLNRILGL 950

  Fly  1542 RVEVQNALFKFFLDKMYSLIMQMKRTGRFDLGILDLDAHGASVKSIKLMRFIRKHATGTAATELH 1606
            .|..||:||::|.|....||...|:.|.:|||||||......:......:|:...........|:
Zfish   951 EVHKQNSLFQYFTDNFDYLIEMDKKVGNYDLGILDLAPGNDQIYEETQEKFLTAGNPQDGQVVLY 1015

  Fly  1607 TVTVERGMSFETALAKYRKEGQYEHEGFYILQKRRQNKNSAILCLQAPSNSSDVSNGKINLQIYR 1671
            .::|:|||.:..||.|:....:.: ||||:..:.|.|....:|.:|....         |:.:|:
Zfish  1016 KISVDRGMPWSEALEKFETLTKPD-EGFYMSYRLRSNHPCVLLAVQGKER---------NMILYK 1070

  Fly  1672 PNTGPQVRLETHASISSRYVKVSPEEAQTYWVQQYELCLNMCSHL-YWNRTCPMPTG--CEVGLR 1733
            ||.|.|::.|:...:..:|.||:|.:.|..|..|:...|..|||. .:.|...:..|  |.:|.|
Zfish  1071 PNIGKQLQPESIDKLQQKYRKVTPADVQDSWENQFNFSLRKCSHANQYGRCKRIDDGQECTMGTR 1135

  Fly  1734 MRTYHVLSGLMLPIWDRIELII--VNSGHKIQIIRMKTDANKKIVGTVVP 1781
            :|.||:|.|.:|.:|.|:..|:  :.|...:||:|:||..:.|.||..:|
Zfish  1136 LRQYHMLCGALLRVWKRVSDIVADITSSSILQIVRLKTKDSNKQVGIKIP 1185

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3491	NP_609731.1	AAA_34	737..1038	CDD:290583	183/302 (61%)
		DEXDc	759..986	CDD:214692	136/228 (60%)
		Helicase_C_4	1297..1576	CDD:290582	163/285 (57%)
si:ch73-63e15.2	XP_001342116.5	AAA_34	210..500	CDD:290583	184/303 (61%)
		Helicase_C_4	708..985	CDD:290582	163/285 (57%)
		Bud13	1198..>1245	CDD:286779
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593972
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1513
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D112455at33208
OrthoFinder	1	1.000	-	-		FOG0002373
OrthoInspector	1	1.000	-	-		otm24346
orthoMCL	1	0.900	-	-		OOG6_102140
Panther	1	1.100	-	-	O	PTHR12706
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1569
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.750