DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(2)34Fc and FRRS1

DIOPT Version :9

Sequence 1:	NP_001285930.1	Gene:	l(2)34Fc / 34838	FlyBaseID:	FBgn0261534	Length:	159	Species:	Drosophila melanogaster
Sequence 2:	NP_001013682.2	Gene:	FRRS1 / 391059	HGNCID:	27622	Length:	626	Species:	Homo sapiens

Alignment Length:	159	Identity:	45/159 - (28%)
Similarity:	73/159 - (45%)	Gaps:	27/159 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LAACLAI----SVHAYSDGAPKAACRDLTPQHGAKLQVTKPPYSISGPSH--------VRSDQKL 59
            |..|:.:    .|..|.:|....:|..:.|:||      ..|.|:  |.|        .|...::
Human     8 LGTCILLLHISYVANYPNGKVTQSCHGMIPEHG------HSPQSV--PVHDIYVSQMTFRPGDQI 64

  Fly    60 TLTLGGDEFLGFMIQARDGQN---RVVGQFQVVDSVHSQTLDCSG-KDDTITHLSAQKGKPLTGI 120
            .:||.|..|.||:::||:.::   ..:|.|.::||..||.|.|.. :...::|.||.|   .|.|
Human    65 EVTLSGHPFKGFLLEARNAEDLNGPPIGSFTLIDSEVSQLLTCEDIQGSAVSHRSASK---KTEI 126

  Fly   121 TFDWIPPAGYKGNVKFMATVVQTGFVYWV 149
            ...|..|:....:.:|:.|||:...:|||
Human   127 KVYWNAPSSAPNHTQFLVTVVEKYKIYWV 155

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)34Fc	NP_001285930.1	Reeler	27..149	CDD:280232	38/133 (29%)
FRRS1	NP_001013682.2	Reeler	32..155	CDD:307916	38/133 (29%)
		DOMON_SDR_2_like	192..354	CDD:187686
		Cyt_b561_FRRS1_like	320..533	CDD:176490
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141358
Domainoid	1	1.000	59	1.000	Domainoid score	I10765
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7160
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001198
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45828
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3670
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.920