DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG46301 and Nol4l

DIOPT Version :9

Sequence 1:	NP_001334737.1	Gene:	CG46301 / 34829	FlyBaseID:	FBgn0283651	Length:	1237	Species:	Drosophila melanogaster
Sequence 2:	XP_038962599.1	Gene:	Nol4l / 362240	RGDID:	1563510	Length:	679	Species:	Rattus norvegicus

Alignment Length:	1199	Identity:	303/1199 - (25%)
Similarity:	399/1199 - (33%)	Gaps:	562/1199 - (46%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 ELEQPTAEREIIYELFQPWALSTYGDQAKTKTITLRKKARILKALEG----KEHSRP---DSSKF 124
            |.|:...:.|:..: |:.|.|.||||.|||||:|..|..||.:.|:|    ...|.|   :..||
  Rat    13 ERERSPGDSELGRQ-FRDWCLRTYGDSAKTKTVTRSKYQRIAEVLQGGGGTGAGSGPAAGEKGKF 76

  Fly   125 RFWVKTKGFTTNRPEGFEEAPGSRRHLK--NLPSSAILSDNPADVDLFAASTSKGFGRRTYRKVA 187
            :|||::|||..          ||.|..|  .:....:.:.:.||    ..|..:|.   :.::||
  Rat    77 QFWVRSKGFRL----------GSGREPKMGQVVYVPVKTGSGAD----GLSEPEGI---SLKRVA 124

  Fly   188 CVEEFFDIIYNVHMELG---GRSGMHAGQKRTYRIITETYAFLPREAVTRFLTICPECKKNLRPS 249
            .||:||||||::|:|..   |::..|||||:|||.|.|||||||||||||||..|.||:|.:
  Rat   125 VVEDFFDIIYSMHVESSAEPGKAPKHAGQKKTYRAIAETYAFLPREAVTRFLMSCTECQKRM--- 186

  Fly   250 SPSGGGKDSDLAGNESSSEVENYLNYSSHTESSLEAGPTAKRRRHSSAEIKASLASGLAVGAGVA 314
                                        |..||   ||..|..     |..:.|.||:   ....
  Rat   187 ----------------------------HFNSS---GPEPKEN-----EPPSPLVSGI---IDYN 212

  Fly   315 SSMSATQLDVLWTGVPRSRSPKPPMAAEAAVETTPVSVPKIRIKTQLQRPSSPQDQSPADPNTDA 379
            ..:::|.|..:...|..|:..          :.|.||.....:.......:.|...|...||.:.
  Rat   213 MPLTSTYLKQMKLRVMNSQEQ----------DETSVSSEDFDMNDSTWMSADPHLASSLSPNQEE 267

  Fly   380 QSQSQIQSQSQSQSQSQSQSHSQPSGQGFDAQLLKSRDNLLRYYNFMRRFYAGEPVLAPPIYGSS 444
            :.:|.....||....|.|:|   .||.|
  Rat   268 RMRSPQNLHSQEDDDSSSES---GSGNG------------------------------------- 292

  Fly   445 LLQSLSYPTTISTAATATPTTPTTTTSAPGKMLAPPKTATPPPNPPKIKTSPDSLLRARTPPVAS 509
                         ::|..|:|.::|...|         |.|..|
  Rat   293 -------------SSTLNPSTSSSTQGDP---------AFPEMN--------------------- 314

  Fly   510 TATSAAPKD----AAHTPINLTKSLFSSLKTGHAPSTSTPVPLKLELPSPPKPLPELRIPQLRGM 570
            ...:|||.|    |...||||.:.
  Rat   315 GNGAAAPMDFTASAEDQPINLCEK----------------------------------------- 338

  Fly   571 PPVELSLPLPPLDLERLKPITSTYLQLTRSMGLSDEDALRFDNLETIPATPVVSTDTASVVGVGV 635
                    |||                                 .|...||...:|..
  Rat   339 --------LPP---------------------------------GTALGTPSYPSDGC------- 355

  Fly   636 GGGGGAAAGAGGGAGGAGGLLGDVVSGLGGGLVNESEAYAGLMKDADKLKLMLLAWNYQNSTAVR 700
                           |..||...|..|                                    |:
  Rat   356 ---------------GTDGLRSRVKYG------------------------------------VK 369

  Fly   701 NGTEGPDLSVVGGLWAQYQNALAQNAAAAAAASGKMDS---SLSPVPRQDAHSPMETQDETNSSG 762
            :..|.|..|                       ||..||   .:|..|          :|.|....
  Rat   370 STPESPPYS-----------------------SGSYDSIKTEVSGCP----------EDLTVGRA 401

  Fly   763 QKEEDEVSEDDSDDKLD-EKLATTH--DPERLKAFNMFVRLFVDENLDRIIPISKQPKEKIQAII 824
            ...:|:  :||.||..| :|:..:.  ||||||||||||||||||||||::||||||||||||||
  Rat   402 PAADDD--DDDHDDHEDNDKMNDSEGMDPERLKAFNMFVRLFVDENLDRMVPISKQPKEKIQAII 464

  Fly   825 DSCARQFPEFSDRSRKRIRTYLKSCRRNKKTRDGWENTTRPTPAHLTSVQAEQILAIACENESMN 889
            :||:||||||.:|:|||||||||||||.||  :|.| .|||||.||||..||.|||.|||:|:..
  Rat   465 ESCSRQFPEFQERARKRIRTYLKSCRRMKK--NGME-MTRPTPPHLTSAMAENILAAACESETRK 526

  Fly   890 -AKRMRIGL------EPITHAVPAPGSAVAAAAAAAAAAAVVAATSSSAGGTSTTAAGNATATCG 947
             |||||:.:      |||......|
  Rat   527 AAKRMRLEIYQSSQEEPIALDKQHP---------------------------------------- 551

  Fly   948 MGGVGDATGLTSAAAAALPFVSAVGFARSTPNSEHADVLPFGGAGTAGGSGGGGAGGGGGGGMSS 1012
                .|:|.:|.:             ..|.|.|.::.       .....:||......|.|.:||
  Rat   552 ----RDSTAITHS-------------TYSLPASAYSQ-------DPVYVNGGLNYSYRGYGSLSS 592

  Fly  1013 ARSSPLALSSNASVSGGASVTGLTLANGAGASNGAGLPASSPYTTDFSSPSTASPFVAAAAAVAA 1077
                  .|..:||:..|:.            |||
  Rat   593 ------NLQPSASLQTGSH------------SNG------------------------------- 608

  Fly  1078 GRAPSYPGYFPAVAGLGNVTPTDLSMKPTSGLGGNMVSNNNSNSSVTGNINSQLSAANLASLSNA 1142
                                |||||||     ||                   .|.....:.:.:
  Rat   609 --------------------PTDLSMK-----GG-------------------ASTPTPPTPTPS 629

  Fly  1143 SNNNALVTATQQLQQLQQQQQQQQQQQQQQQQQQLLVAGGGGMDGQSVRAPPILPHKLSANEVTA 1207
            ||:.:....|.|                                             ||..|::|
  Rat   630 SNSTSRTMPTAQ---------------------------------------------LSPTEISA 649

  Fly  1208 ARQVISAYRESAAFLLRTADQVEQLLVQQ 1236
            .||:|:.||||||||||:||::|.|::||
  Rat   650 VRQLIAGYRESAAFLLRSADELENLILQQ 678

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG46301	NP_001334737.1	None
Nol4l	XP_038962599.1	Integrase_H2C2	131..185	CDD:407771	34/53 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003616
OrthoInspector	1	1.000	-	-		oto97409
orthoMCL	1	0.900	-	-		OOG6_106349
Panther	1	1.100	-	-	O	PTHR12449
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2493
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.000