DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG46301 and nol4

DIOPT Version :9

Sequence 1:	NP_001334737.1	Gene:	CG46301 / 34829	FlyBaseID:	FBgn0283651	Length:	1237	Species:	Drosophila melanogaster
Sequence 2:	XP_031759782.1	Gene:	nol4 / 100494971	XenbaseID:	XB-GENE-6037484	Length:	635	Species:	Xenopus tropicalis

Alignment Length:	1177	Identity:	289/1177 - (24%)
Similarity:	383/1177 - (32%)	Gaps:	567/1177 - (48%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 IYELFQPWALSTYGDQAKTKTITLRKKARILKALEGKEHSRPDSSKFRFWVKTKGFTTNRPEGFE 142
            :|..||.|.|.||||..||||:|.:|..||::.|.|.|.|..|::||:||||:|||
Frog     7 MYRQFQDWCLRTYGDSGKTKTVTRKKYERIVQLLNGSESSSTDNAKFKFWVKSKGF--------- 62

  Fly   143 EAPGSRRHLKNLPSSAILSDNPADVDLFAASTSKGFG---RRTYRKVACVEEFFDIIYNVHMELG 204
                      .|..:..|:.....|......|:.|.|   :.:.|:||.||:||||||::|:|.|
Frog    63 ----------QLGDADELNVGDQQVLFVPVKTTDGVGIEEKLSLRRVAVVEDFFDIIYSMHVETG 117

  Fly   205 GRSGM---HAGQKRTYRIITETYAFLPREAVTRFLTICPECKKNLRPSSPSGGGKDSDLAGNESS 266
            .....   ||||||||:.|:|||||||||||||||..|.||:|.:. .:|.||
Frog   118 PNGEQIRKHAGQKRTYKAISETYAFLPREAVTRFLMSCSECQKRMH-LNPDGG------------ 169

  Fly   267 SEVENYLNYSSHTESSLEAGPTAKRRRHSSAEIKASLASGLAVGAGVASSMSATQLDVLWTGVPR 331
                      .|.::.
Frog   170 ----------EHKDNG------------------------------------------------- 175

  Fly   332 SRSPKPPMAAEAAVE-TTPVSVPKIR-IKTQLQRPSSPQDQSPADPN----TDAQSQSQIQSQSQ 390
                |||....:.:: ..|:::..:: :|.||......:|:|..:.:    :|:...|.:.|...
Frog   176 ----KPPTLVTSMIDYNMPITMAYMKHMKLQLLNSQQDEDESSIESDEFDMSDSTRMSAVNSDLS 236

  Fly   391 SQSQSQSQSHSQPSGQGFDAQLLKSRDNLLRYYNFMRRFYAGEPVLAPPIYGSSLLQSLSYPTTI 455
            |..:.:.||.....||..|                                 .|..:|.:...|:
Frog   237 SNLEERMQSPQNLQGQQDD---------------------------------DSAAESYTCNETV 268

  Fly   456 STAATATPTTPTTTTSAPGKMLAPPKTATPPPNPPKIKTSPDSLLRARTPPVASTATSAAPKDAA 520
            ..|:.:|..|                                   ..|......|....|..:..
Frog   269 GQASNSTGAT-----------------------------------HNREMMEVITTNGNAISEQE 298

  Fly   521 HTPINLTKSLFSSLKTGHAPSTSTPVPLKLELPSPPKPLPELRIP--QLRGMPPVELSLPLPPLD 583
            ..|:||               :..||..:|.        ||.||.  ...|..|
Frog   299 EQPLNL---------------SDCPVSSQLN--------PEYRIDDHSSNGKHP----------- 329

  Fly   584 LERLKPITSTYLQLTRSMGLSDEDALRFDNLETIPATPVVSTDTASVVGVGVGGGGGAAAGAGGG 648
                                       :.||
Frog   330 ---------------------------YKNL---------------------------------- 333

  Fly   649 AGGAGGLLGDVVSGLGGGLVNESEAYAGLMKDADKLKLMLLAWNYQNSTAVRNGTEGPDLSVVGG 713
                  |:||                         ||:        :..|..||.:.|..|
Frog   334 ------LIGD-------------------------LKM--------DREARENGNKSPAHS---- 355

  Fly   714 LWAQYQNALAQNAAAAAAASGKMDSSLSPVPRQDAHSPMETQDETNSSGQKEEDEVSEDDSDDKL 778
             ::.|.             |||.:|             :....|..|..:.:||   |||.||..
Frog   356 -YSSYD-------------SGKNES-------------VGGCGEDLSMTRGDED---EDDHDDHE 390

  Fly   779 DEKLATTHD---PERLKAFNMFVRLFVDENLDRIIPISKQPKEKIQAIIDSCARQFPEFSDRSRK 840
            |.:.|...|   .||||||||||||||||||||::|||||||||||||||||.|||||:.:|:||
Frog   391 DAEKAAESDGVEAERLKAFNMFVRLFVDENLDRMVPISKQPKEKIQAIIDSCRRQFPEYQERARK 455

  Fly   841 RIRTYLKSCRRNKKTRDGWENTTRPTPAHLTSVQAEQILAIACENESMN-AKRMRIGLEPITHAV 904
            |||||||||||.|  |.|:| .:||.|:||||..||.|||.|||:||.| |||||:..:..|  .
Frog   456 RIRTYLKSCRRMK--RSGFE-MSRPIPSHLTSAVAETILASACESESRNAAKRMRLDRQDET--P 515

  Fly   905 PAPGSAVAAAAAAAAAAAVVAATSSSAGGTSTTAAGNATATCGMGGVGDATGLTSAAAAALPFVS 969
            ||..|.....|....:.:.|::|.
Frog   516 PADKSHKQDTAQVTYSTSAVSSTQ----------------------------------------- 539

  Fly   970 AVGFARSTPNSEHADVLPFGGAGTAGGSGGGGAGGGGGGGMSSARSSPLALSSNASVSGGASVTG 1034
                          |||...|.||.......|.|||
Frog   540 --------------DVLYINGNGTYSYHTYRGLGGG----------------------------- 561

  Fly  1035 LTLANGAGASNGAGLPASSPYTTDFSSPSTASPFVAAAAAVAAGRAPSYPGYFPAVAGLGNVTPT 1099
              |.|.:..||..                                                  ||
Frog   562 --LLNLSDTSNSG--------------------------------------------------PT 574

  Fly  1100 DLSMKPTSGLGGNMVSNNNSNSSVTGNINSQLSAANLASLSNASNNNALVTATQQLQQLQQQQQQ 1164
            |||||                         :..|.:..|.||.||..
Frog   575 DLSMK-------------------------RPLATSSTSPSNTSNRT------------------ 596

  Fly  1165 QQQQQQQQQQQQLLVAGGGGMDGQSVRAPPILPHKLSANEVTAARQVISAYRESAAFLLRTADQV 1229
                                              :|:..|:.|.||:::.||||||||||:||::
Frog   597 ----------------------------------QLNPTEINAVRQLVAGYRESAAFLLRSADEL 627

  Fly  1230 EQLLVQQ 1236
            |.|::||
Frog   628 ENLILQQ 634

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG46301	NP_001334737.1	None
nol4	XP_031759782.1	Integrase_H2C2	107..161	CDD:407771	34/53 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	313	1.000	Domainoid score	I1286
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	313	1.000	Inparanoid score	I2532
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003616
OrthoInspector	1	1.000	-	-		otm48715
Panther	1	1.100	-	-	LDO	PTHR12449
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2493
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.060