DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18095 and kera

DIOPT Version :9

Sequence 1:	NP_001188805.1	Gene:	CG18095 / 34823	FlyBaseID:	FBgn0028872	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_001020719.1	Gene:	kera / 567017	ZFINID:	ZDB-GENE-041210-165	Length:	348	Species:	Danio rerio

Alignment Length:	270	Identity:	76/270 - (28%)
Similarity:	127/270 - (47%)	Gaps:	38/270 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   116 LDLSHNMLSKLSVKSFEQYPQLQQLDLRYNRISQ--IENDSFDGLSHLKHLYLNGNQLAHIDGSF 178
            |.|.:|::..||..:.....||:.::|..|:|:.  :|.|:...:|:|.|||:..|.|:.|....
Zfish    75 LYLQNNLIDVLSANALRNATQLKWINLNRNKITTEGLEVDALRAMSNLVHLYMEDNLLSSIPSPL 139

  Fly   179 FRGLHRLSSLSLQHNRIEFIEMDSFESNTHLRSLRLDQNLL--SSLQFLSQRGLARLVHLNLSSN 241
               ..:|..|.|..|:|..|....|....||..|.|..|.|  .::..:|.:||..|:.:||:.|
Zfish   140 ---PAKLEQLRLSRNKISKIPPGVFSGMGHLTLLDLQSNKLQDDAVTEVSLKGLNNLIQINLAKN 201

  Fly   242 LLQKLE---PFVFSKNFELQDLDLSYNNITKLNKEALSGLDSLERLNISHNYVDKIYD----ESL 299
            .|..:.   |...::.|      |..|||.|:..|...||..:..|.::.|   |:.:    :::
Zfish   202 QLNSMPLGLPPTTTQIF------LDGNNIEKIPAEYFKGLPKVASLRLNRN---KLANGGIPKNV 257

  Fly   300 DSLIALLQLDISFNLLTTLPDNLFHFNTQLEEIILANNKIEEISS-----------QMMFNQNHL 353
            .:|.::|.|.:|.|.||.:|    ..::.||.:.|.:|||:.::|           .:......|
Zfish   258 FNLSSILDLQLSHNQLTEVP----VISSGLEHLHLDHNKIKSVNSSDICPPGVLDDHLEEKSPRL 318

  Fly   354 RYIKLSGNAI 363
            ||::|.||.|
Zfish   319 RYLRLDGNEI 328

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18095	NP_001188805.1	leucine-rich repeat	41..64	CDD:275380
		LRR_8	64..123	CDD:290566	3/6 (50%)
		leucine-rich repeat	65..88	CDD:275380
		leucine-rich repeat	89..112	CDD:275380
		leucine-rich repeat	113..136	CDD:275380	5/19 (26%)
		LRR_RI	115..384	CDD:238064	76/270 (28%)
		LRR_8	135..195	CDD:290566	19/61 (31%)
		leucine-rich repeat	137..160	CDD:275380	6/24 (25%)
		leucine-rich repeat	161..184	CDD:275380	7/22 (32%)
		LRR_8	184..243	CDD:290566	20/60 (33%)
		leucine-rich repeat	185..208	CDD:275380	7/22 (32%)
		leucine-rich repeat	209..232	CDD:275380	8/24 (33%)
		LRR_8	232..289	CDD:290566	16/59 (27%)
		leucine-rich repeat	233..256	CDD:275380	6/25 (24%)
		leucine-rich repeat	257..280	CDD:275380	8/22 (36%)
		LRR_8	280..339	CDD:290566	15/62 (24%)
		leucine-rich repeat	281..304	CDD:275380	4/26 (15%)
		leucine-rich repeat	305..328	CDD:275380	7/22 (32%)
kera	NP_001020719.1	NEL	<28..>165	CDD:330839	27/92 (29%)
		LRR 1. /evidence=ECO:0000255	70..92		5/16 (31%)
		leucine-rich repeat	72..95	CDD:275380	5/19 (26%)
		LRR 2. /evidence=ECO:0000255	93..118		7/24 (29%)
		leucine-rich repeat	96..121	CDD:275380	6/24 (25%)
		NEL	<105..>291	CDD:330839	56/201 (28%)
		LRR 3. /evidence=ECO:0000255	119..140		8/23 (35%)
		leucine-rich repeat	122..142	CDD:275380	7/22 (32%)
		LRR 4. /evidence=ECO:0000255	141..163		7/21 (33%)
		leucine-rich repeat	143..166	CDD:275380	7/22 (32%)
		LRR 5. /evidence=ECO:0000255	165..189		7/23 (30%)
		leucine-rich repeat	167..192	CDD:275380	8/24 (33%)
		LRR 6. /evidence=ECO:0000255	190..213		7/22 (32%)
		leucine-rich repeat	193..216	CDD:275380	6/22 (27%)
		LRR 7. /evidence=ECO:0000255	215..234		7/24 (29%)
		leucine-rich repeat	217..237	CDD:275380	9/25 (36%)
		LRR 8. /evidence=ECO:0000255	235..260		4/27 (15%)
		leucine-rich repeat	238..262	CDD:275380	4/26 (15%)
		LRR 9. /evidence=ECO:0000255	262..280		7/21 (33%)
		LRR_8	266..328	CDD:316378	19/65 (29%)
		LRR 10. /evidence=ECO:0000255	281..303		7/21 (33%)
		leucine-rich repeat	318..339	CDD:275380	7/11 (64%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45712
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100