DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rk and Flrt3

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_001165631.1	Gene:	Flrt3 / 71436	MGIID:	1918686	Length:	649	Species:	Mus musculus

Alignment Length:	589	Identity:	135/589 - (22%)
Similarity:	209/589 - (35%)	Gaps:	186/589 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 KSASVTPTGIRENVMLPSADPEKEAQILYEKSLQEYHGSQLSTASTATDVIAGKRTLHSICERWL 148
            :|.:..|.||.|           :|..||   ||   .:|::.....:|:
Mouse    47 RSLTSIPVGIPE-----------DATTLY---LQ---NNQINNVGIPSDL--------------- 79

  Fly   149 QKHCHCTGSLEVLRLSCRGIGILAVPVNLPNEVVVLDLGNNNLTKLEANSFFMAPNLEELTLSDN 213
                  ...|:|.|:......:...|.|||..|..|.|..||:..:..:|....|.||||.|.||
Mouse    80 ------KNLLKVQRIYLYHNSLDEFPTNLPKYVKELHLQENNIRTITYDSLSKIPYLEELHLDDN 138

  Fly   214 SI--INMDPNAFYGLAKLKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNGNALVSLDGDCLGHLQK 276
            |:  ::::..||.....|:.|.|....|.::|                            |.|.:
Mouse   139 SVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIP----------------------------GGLPR 175

  Fly   277 -LRTLRLEGNLFYRIPTNALAGLRTLEALNLGSNLLTI--INDEDFPRMPNLIVLLLKRNQIMKI 338
             :..|||:.|....|.:.:|.||.:|:.|.|..|||..  :.|:.|..:.||..|.|.||.:
Mouse   176 TIEELRLDDNRISTISSPSLHGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRNSL--- 237

  Fly   339 SAGALKNL--TALKVLELDDNLISSLPEGLSKLSQLQELSITSNRLRWINDTELPRSMQMLDMRA 401
             ..|..||  |:|:.|.|.||.|:.:|               .|...::      |.:..|||..
Mouse   238 -TAAPVNLPGTSLRKLYLQDNHINRVP---------------PNAFSYL------RQLYRLDMSN 280

  Fly   402 NPLSTISPGAFRGMSKLRKLILSDVRTLRSFPELEACHALEILKLDRAGIQEVPAN------LCR 460
            |.||.:..|.|..:..:.:||      ||:.|....|.    :|..|..:|.:|..      :|:
Mouse   281 NNLSNLPQGIFDDLDNITQLI------LRNNPWYCGCK----MKWVRDWLQSLPVKVNVRGLMCQ 335

  Fly   461 QTPRLKSLELKTNSLKRIPNLSSCRD------LRLLDLSSNQIEKIQGK-PFNGLKQ---LNDLL 515
            ...:::.:.:|..|.:    |..|:|      :::.....|.....||: |....||   .|..|
Mouse   336 APEKVRGMAIKDLSAE----LFDCKDSGIVSTIQITTAIPNTAYPAQGQWPAPVTKQPDIKNPKL 396

  Fly   516 LSYNR-------------IKALPQDAFQGIPKLQLLDLEGNEISYI---HKEAFSGF-------- 556
            :...|             :|::..|... |.....|.:....:|::   |..||...
Mouse   397 IKDQRTTGSPSRKTILITVKSVTPDTIH-ISWRLALPMTALRLSWLKLGHSPAFGSITETIVTGE 460

  Fly   557 ------TALEDLNLGNNIFPELPESGLR-ALLHLKTFN--------------NPKLREFPPPDTF 600
                  ||||            |||..| .::.::|.|              ...||.:.|..|.
Mouse   461 RSEYLVTALE------------PESPYRVCMVPMETSNLYLFDETPVCIETQTAPLRMYNPTTTL 513

  Fly   601 PRIQ 604
            .|.|
Mouse   514 NREQ 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	6/20 (30%)
		LRR_RI	180..>383	CDD:238064	58/209 (28%)
		leucine-rich repeat	183..204	CDD:275380	5/20 (25%)
		LRR_8	203..263	CDD:290566	16/61 (26%)
		leucine-rich repeat	205..228	CDD:275380	10/24 (42%)
		leucine-rich repeat	229..252	CDD:275380	5/22 (23%)
		LRR_8	252..311	CDD:290566	14/59 (24%)
		leucine-rich repeat	253..276	CDD:275380	2/22 (9%)
		leucine-rich repeat	277..300	CDD:275380	8/22 (36%)
		LRR_8	299..359	CDD:290566	23/63 (37%)
		leucine-rich repeat	301..324	CDD:275380	8/24 (33%)
		leucine-rich repeat	325..348	CDD:275380	8/24 (33%)
		LRR_RI	327..567	CDD:238064	62/287 (22%)
		leucine-rich repeat	349..371	CDD:275380	7/21 (33%)
		LRR_8	370..425	CDD:290566	12/54 (22%)
		leucine-rich repeat	372..393	CDD:275380	1/20 (5%)
		leucine-rich repeat	394..415	CDD:275380	8/20 (40%)
		leucine-rich repeat	418..486	CDD:275380	15/73 (21%)
		leucine-rich repeat	441..464	CDD:275378	5/28 (18%)
		LRR_8	487..545	CDD:290566	13/74 (18%)
		leucine-rich repeat	487..510	CDD:275380	4/23 (17%)
		leucine-rich repeat	511..534	CDD:275380	6/35 (17%)
		LRR_8	533..589	CDD:290566	15/87 (17%)
		leucine-rich repeat	535..558	CDD:275380	5/39 (13%)
		leucine-rich repeat	559..580	CDD:275380	6/21 (29%)
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
Flrt3	NP_001165631.1	LRRNT	31..61	CDD:214470	5/24 (21%)
		Interaction with ADGRL3. /evidence=ECO:0000250\|UniProtKB:Q9NZU0	38..67		10/36 (28%)
		LRR 1. /evidence=ECO:0000255	58..82		8/61 (13%)
		LRR_4	61..100	CDD:289563	9/65 (14%)
		leucine-rich repeat	61..84	CDD:275378	6/49 (12%)
		LRR 2. /evidence=ECO:0000255	83..105		7/21 (33%)
		leucine-rich repeat	85..104	CDD:275380	5/18 (28%)
		LRR_8	106..166	CDD:290566	20/59 (34%)
		leucine-rich repeat	106..129	CDD:275380	6/22 (27%)
		LRR_RI	107..327	CDD:238064	76/282 (27%)
		LRR 3. /evidence=ECO:0000255	107..126		5/18 (28%)
		LRR 4. /evidence=ECO:0000255	127..152		11/24 (46%)
		leucine-rich repeat	130..155	CDD:275380	10/24 (42%)
		LRR 5. /evidence=ECO:0000255	153..176		7/50 (14%)
		leucine-rich repeat	156..176	CDD:275380	7/47 (15%)
		LRR_8	175..237	CDD:290566	22/61 (36%)
		leucine-rich repeat	177..200	CDD:275380	8/22 (36%)
		LRR 6. /evidence=ECO:0000255	178..197		6/18 (33%)
		LRR 7. /evidence=ECO:0000255	198..223		9/24 (38%)
		leucine-rich repeat	201..226	CDD:275380	8/24 (33%)
		LRR 8. /evidence=ECO:0000255	224..246		9/25 (36%)
		leucine-rich repeat	227..248	CDD:275380	8/24 (33%)
		LRR_8	247..306	CDD:290566	22/85 (26%)
		LRR 9. /evidence=ECO:0000255	247..269		9/36 (25%)
		leucine-rich repeat	249..272	CDD:275380	8/43 (19%)
		LRR 10. /evidence=ECO:0000255	270..293		9/28 (32%)
		leucine-rich repeat	273..296	CDD:275380	8/22 (36%)
		LRRCT	305..356	CDD:214507	10/58 (17%)
		fn3	413..478	CDD:278470	16/77 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	629..649
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910