DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rk and AgaP_AGAP012442

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	XP_001230904.2	Gene:	AgaP_AGAP012442 / 4578491	VectorBaseID:	AGAP012442	Length:	335	Species:	Anopheles gambiae

Alignment Length:	344	Identity:	78/344 - (22%)
Similarity:	152/344 - (44%)	Gaps:	32/344 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   228 KLKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNGNALVSLDGDCLGHLQKLRTLRLEGNLFYRIPT 292
            :||.|.:.|..|..: |.|.:.|..|..|.:.|:.:..:|...:..::.|..|.::.:....:.:
Mosquito    18 ELKTLLIVNSHLNEI-PSSLKNLTSLNILTIRGSKISVVDLSLVSRMKMLTDLVIDVSKISSLAS 81

  Fly   293 NALAGLRT-LEALNLGSNLLTIINDEDFPRMPNLIVLLLKRNQIMKISAGALKNLTALKVLELDD 356
            ::.|..:: |:.:.|..|||..||.:.......|....:..|.: ..|.|::.| :.|:.|.|.|
Mosquito    82 HSQAITQSVLKHIKLRHNLLKSINFDQLKPFGMLQTFDITHNSV-NTSTGSVSN-SQLQRLNLGD 144

  Fly   357 N-LISSLPEGLSKLSQLQELSITSNRLRWIND--TELPRSMQMLDMRANPLSTISPGAFRGMSKL 418
            | :......|.::||.:..|::.:|:|:.|.:  ...|..:. ||...|.:.::....|...
Mosquito   145 NDMAYFFFCGWTELSNVSYLAVPNNQLQHIPNCLATFPNIIS-LDFSFNRIRSVKMLTFTNS--- 205

  Fly   419 RKLILSDVRTLRSFPELEACHALEILKLDRAGIQEVPANLCRQTPRLKSLELKTNSLKRIPNLSS 483
                 :|:.||:.:     .:.|...:.|          |.:...:|.:|::..|.::.:....:
Mosquito   206 -----TDLTTLKLW-----YNQLTTFQFD----------LVKPFQKLHTLDIAHNVIRSVVGNLT 250

  Fly   484 CRDLRLLDLSSNQIEKIQGKPFNGLKQLNDLLLSYNRIKALPQDAFQGIPKLQLLDLEGNEISYI 548
            .:.||...:..|.:.|:....:|.:..|..|.:.:||::.:| ......|.:.||||..|.|:::
Mosquito   251 NQSLRYFAIQHNLVSKLDFCSWNEIASLEWLSIGHNRLRYVP-SCLTTFPNVTLLDLSFNWINHV 314

  Fly   549 HKEAFSGFTALEDLNLGNN 567
            ....|.|...|:||.||.|
Mosquito   315 QMHMFVGLNNLKDLYLGGN 333

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380
		LRR_RI	180..>383	CDD:238064	37/156 (24%)
		leucine-rich repeat	183..204	CDD:275380
		LRR_8	203..263	CDD:290566	11/34 (32%)
		leucine-rich repeat	205..228	CDD:275380	78/344 (23%)
		leucine-rich repeat	229..252	CDD:275380	8/22 (36%)
		LRR_8	252..311	CDD:290566	10/59 (17%)
		leucine-rich repeat	253..276	CDD:275380	4/22 (18%)
		leucine-rich repeat	277..300	CDD:275380	3/22 (14%)
		LRR_8	299..359	CDD:290566	17/61 (28%)
		leucine-rich repeat	301..324	CDD:275380	7/22 (32%)
		leucine-rich repeat	325..348	CDD:275380	5/22 (23%)
		LRR_RI	327..567	CDD:238064	54/242 (22%)
		leucine-rich repeat	349..371	CDD:275380	7/22 (32%)
		LRR_8	370..425	CDD:290566	10/56 (18%)
		leucine-rich repeat	372..393	CDD:275380	5/22 (23%)
		leucine-rich repeat	394..415	CDD:275380	4/20 (20%)
		leucine-rich repeat	418..486	CDD:275380	9/67 (13%)
		leucine-rich repeat	441..464	CDD:275378	3/22 (14%)
		LRR_8	487..545	CDD:290566	16/57 (28%)
		leucine-rich repeat	487..510	CDD:275380	5/22 (23%)
		leucine-rich repeat	511..534	CDD:275380	5/22 (23%)
		LRR_8	533..589	CDD:290566	15/35 (43%)
		leucine-rich repeat	535..558	CDD:275380	8/22 (36%)
		leucine-rich repeat	559..580	CDD:275380	6/9 (67%)
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
AgaP_AGAP012442	XP_001230904.2	leucine-rich repeat	19..41	CDD:275380	8/22 (36%)
		leucine-rich repeat	42..65	CDD:275380	4/22 (18%)
		leucine-rich repeat	66..89	CDD:275380	3/22 (14%)
		leucine-rich repeat	91..114	CDD:275380	7/22 (32%)
		leucine-rich repeat	115..134	CDD:275380	4/19 (21%)
		leucine-rich repeat	137..160	CDD:275380	7/22 (32%)
		LRR	<159..>309	CDD:227223	34/174 (20%)
		leucine-rich repeat	161..183	CDD:275380	4/21 (19%)
		leucine-rich repeat	184..207	CDD:275380	4/31 (13%)
		leucine-rich repeat	208..231	CDD:275380	5/37 (14%)
		leucine-rich repeat	232..251	CDD:275380	3/18 (17%)
		leucine-rich repeat	254..277	CDD:275380	5/22 (23%)
		LRR_8	277..335	CDD:290566	20/58 (34%)
		leucine-rich repeat	278..300	CDD:275380	5/22 (23%)
		leucine-rich repeat	301..324	CDD:275380	8/22 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910