DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rk and Lgr1

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_524393.2	Gene:	Lgr1 / 42133	FlyBaseID:	FBgn0016650	Length:	831	Species:	Drosophila melanogaster

Alignment Length:	828	Identity:	243/828 - (29%)
Similarity:	385/828 - (46%)	Gaps:	170/828 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   297 GLRTLE-----ALNLGSNLLTIINDEDFPRMPNLIVLLLKRNQIMKISAG--ALKNLTALKVLEL 354
            ||:.|.     .|.|...|||.::...|....:.:...|..|....|..|  ...||||:.:.:.
  Fly    20 GLKCLSFEFQCRLLLHHLLLTSLSGRHFVYATSAVGGALSANNCHDIHHGFDVYPNLTAVSLAQS 84

  Fly   355 DDN-LISSLP------------------------EGLSKLSQ-----LQELSITSNRLRWINDTE 389
            .|. |.:::|                        :||:::.|     :|.|:|.|..|..:..|.
  Fly    85 TDTPLTATMPRSAWKCCCWNASNQAEEVECRCEGDGLNRVPQTLTLPIQRLTIASAGLPRLRHTG 149

  Fly   390 LP-RSMQMLDMRAN---PLSTISPGAFRGMSKLRKLILSDVRTLRSFPE---LEACHALEILKLD 447
            |. ....:||:...   .|..|..|||..::.||.:.:::...|....:   |.....::|:::.
  Fly   150 LKVYGSTLLDVAFTDCLQLELIQDGAFANLTLLRTIYITNAPKLTFLSKDVFLGISDTVDIIRII 214

  Fly   448 RAGIQEVPANLCRQTPRLKSLELKTNSLKRIP--NLSSCRDLRLLDLSSNQIEKIQGKPFNGLKQ 510
            .:|:..||                  .|..:|  |:     |:::||.:|||.:|..|...  .:
  Fly   215 NSGLTRVP------------------DLGHLPPHNI-----LQMIDLDNNQITRIDSKSIK--VK 254

  Fly   511 LNDLLLSYNRIKALPQDAFQG--IPKLQLLDLEGNEISYIHKEAFSGFTALEDLNLGNNIFPELP 573
            ...|:|:.|.|..:...||.|  |.||.|  .|..::..:|..||.|...:.:|:|.:.....||
  Fly   255 TAQLILTNNEISYVDDSAFFGSKIAKLSL--KENKKLQMMHPNAFDGIIDITELDLSSTSLVGLP 317

  Fly   574 ESGLRALLHLKTFNNPKLREFPPPDTFPRIQTLILSYAYHCCAFLPLVAMSSQKKTSQVQEAVLF 638
            .:||:.:..|...|...|:..|....|..:|...|::::|||||                   .|
  Fly   318 SAGLQNIEALYIQNTHTLKTIPSIYNFRNLQRAYLTHSFHCCAF-------------------QF 363

  Fly   639 PSDAEFDMTLWNNSMMNIWPQMHNLSKQLGASMHDPWETAINFNE-----EQLQTQTGGQIATSY 698
            |                              |.|||...|....|     :|.::.:|.:...|.
  Fly   364 P------------------------------SRHDPQRHAQRMLEIEKWRKQCKSDSGTRKERST 398

  Fly   699 MEEYFEEHDVSG-------------PATGYGF--------GTGLF---------SGMSTE----- 728
            ::..|...:..|             |.|...|        ..|.|         ...|.|
  Fly   399 LDNPFNMPEDFGSFGGTDDSATDITPITFASFDYMADDTMNKGTFHEKIILNPGDDSSAELCGNF 463

  Fly   729 DFQPGSVQCLPMPGPFLPCADLFDWWTLRCGVWVVFLLSLLGNGTVVFVLLCSR-SKMDVPRFLV 792
            .|:..:::|.|||....||.|:..:..||..||:|..|:::||..|:.|:|..| ....|||||:
  Fly   464 TFRKPNIECYPMPNDLNPCEDVMGYQWLRISVWIVVALAVVGNVAVLTVILSIRPESTPVPRFLM 528

  Fly   793 CNLAAADFFMGIYLGILAIVDAATLGEFRMFAIPWQMSVLCQLSGFLAVLSSELSVYTLAVITLE 857
            |:||.||..:|:||.::|.:||.::||:..||..||..:.|:::|||.|.:|.|||:||.|||:|
  Fly   529 CHLAFADLCLGLYLLLVACIDAHSMGEYFNFAYDWQYGLGCKVAGFLTVFASHLSVFTLTVITIE 593

  Fly   858 RNYAITHAIHLNKRLSLKQAGYIMSVGWVFALIMALMPLVGVSDYRKFAVCLPFETTTGPASLTY 922
            |..|||.|::||.|:.|:.|..||..||:::::|:.:||.|:|:|...::|||.|......:: |
  Fly   594 RWLAITQAMYLNHRIKLRPAALIMLGGWIYSMLMSSLPLFGISNYSSTSICLPMENRDVYDTI-Y 657

  Fly   923 VISLMFINGCAFLTLMGCYLKMYWAI----RGSQAWNTNDSRIAKRMALLVFTDFLCWSPIAFFS 983
            :|:::..||.||..:..||.::|.::    |.:...:..:..:||:|||||||:|.||||||||.
  Fly   658 LIAILGSNGVAFSIIAVCYAQIYLSLGRETRQAHQNSPGELSVAKKMALLVFTNFACWSPIAFFG 722

  Fly   984 ITAIFGLQLISLEQAKIFTVFVLPLNSCCNPFLYAIMTKQFKKDCVTL 1031
            :||:.|..||::.::||..||..|||||.:|:||||:|.|:::|..||
  Fly   723 LTALAGYPLINVTKSKILLVFFYPLNSCADPYLYAILTSQYRQDLFTL 770

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380
		LRR_RI	180..>383	CDD:238064	27/122 (22%)
		leucine-rich repeat	183..204	CDD:275380
		LRR_8	203..263	CDD:290566
		leucine-rich repeat	205..228	CDD:275380
		leucine-rich repeat	229..252	CDD:275380
		LRR_8	252..311	CDD:290566	5/18 (28%)
		leucine-rich repeat	253..276	CDD:275380
		leucine-rich repeat	277..300	CDD:275380	2/2 (100%)
		LRR_8	299..359	CDD:290566	16/67 (24%)
		leucine-rich repeat	301..324	CDD:275380	7/27 (26%)
		leucine-rich repeat	325..348	CDD:275380	6/24 (25%)
		LRR_RI	327..567	CDD:238064	65/282 (23%)
		leucine-rich repeat	349..371	CDD:275380	5/46 (11%)
		LRR_8	370..425	CDD:290566	17/63 (27%)
		leucine-rich repeat	372..393	CDD:275380	7/21 (33%)
		leucine-rich repeat	394..415	CDD:275380	7/23 (30%)
		leucine-rich repeat	418..486	CDD:275380	11/72 (15%)
		leucine-rich repeat	441..464	CDD:275378	4/22 (18%)
		LRR_8	487..545	CDD:290566	20/59 (34%)
		leucine-rich repeat	487..510	CDD:275380	8/22 (36%)
		leucine-rich repeat	511..534	CDD:275380	8/24 (33%)
		LRR_8	533..589	CDD:290566	16/55 (29%)
		leucine-rich repeat	535..558	CDD:275380	7/22 (32%)
		leucine-rich repeat	559..580	CDD:275380	6/20 (30%)
		7tm_4	764..>892	CDD:304433	58/128 (45%)
		7tm_1	770..1017	CDD:278431	110/251 (44%)
Lgr1	NP_524393.2	leucine-rich repeat	182..207	CDD:275380	4/24 (17%)
		leucine-rich repeat	208..231	CDD:275380	6/40 (15%)
		leucine-rich repeat	233..256	CDD:275380	8/24 (33%)
		leucine-rich repeat	257..277	CDD:275380	7/19 (37%)
		LRR_8	258..313	CDD:290566	18/56 (32%)
		leucine-rich repeat	278..302	CDD:275380	9/25 (36%)
		leucine-rich repeat	303..323	CDD:275380	6/19 (32%)
		leucine-rich repeat	324..346	CDD:275380	5/21 (24%)
		7tm_1	505..756	CDD:278431	110/251 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	178	1.000	Domainoid score	I2123
eggNOG	1	0.900	-	-		E1_KOG2087
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D36239at33392
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24372
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.920