DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rk and Rxfp1

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	XP_006232570.1	Gene:	Rxfp1 / 295144	RGDID:	1302973	Length:	763	Species:	Rattus norvegicus

Alignment Length:	911	Identity:	205/911 - (22%)
Similarity:	335/911 - (36%)	Gaps:	275/911 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   163 LSCRGIGILAVPVNLPNEVVVLDLGNNNLTKLEANSFFMAPNLEELTLSDNSIINMDPNAFYGLA 227
            |.|.|:.      :..|:....:.|:||...|:.:.:|  .|..:|| |.|||
  Rat    51 LHCNGVD------DCGNQADEDNCGDNNGWSLQLDKYF--ANYYKLT-STNSI------------ 94

  Fly   228 KLKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNGNALVSLDGDCLGHLQKLRTLRLEGNLFYRIPT 292
               ......|.:.|:|........:|...:.|..|:.|:..:       :..:.|:.|....:|.
  Rat    95 ---EAETSECLVGSVPMHCLCRDLELDCDEANLRAVPSVSSN-------VTVMSLQWNFIRTLPP 149

  Fly   293 NALAGLRTLEALNLGSNLLTIINDEDFPRMPNLIVLLLKRNQIMKISAGALKNLTALKVLELDDN 357
            |:                        |....:|..|.|:.|:|..:|..|.:.|.:|..|.|..|
  Rat   150 NS------------------------FRMYHDLQKLCLQNNKIRSVSVSAFRGLHSLTKLYLSHN 190

  Fly   358 LISSLPEGLSKLSQLQELSITSNRLRWINDTELPRSMQMLDMRANPLSTISPGAFRGMSKLRKLI 422
            .|:.|..|:     .::|    :||.|            |.:..|.||.|||..|.|::.|..|:
  Rat   191 RITFLKPGV-----FEDL----HRLEW------------LIIEDNHLSRISPLTFYGLNSLILLV 234

  Fly   423 LSDVRTLRSFPELEACHALEILKLDRAGIQEVPANLCRQTPRLKSLELKTNSLKRIPNLS--SCR 485
            |.: ..|...|:                     ..||:..|||..|:.:.|.:..:.||:  ||.
  Rat   235 LMN-NALTRLPD---------------------KPLCQHMPRLHWLDFEGNRIHNLRNLTFISCN 277

  Fly   486 DLRLLDLSSNQIEKIQGKPFNGLKQLNDLLLSYNRIKALPQDAFQGIPKLQLLDLEGNEISYIHK 550
            :|.:|.:..|:|..:....|..|::|::|.|..|:|:.||.:.|:.:.:|..|::..|.|..|..
  Rat   278 NLTVLVMRKNKINHLNEHAFTHLQKLDELDLGSNKIENLPPNIFKDLKELSQLNISYNPIQKIEV 342

  Fly   551 EAFSGFTALEDLNLGNNIFPELPESGLRALLHLKTFNNPKLREFPPPDTFPRIQTLILSYAY--- 612
            ..|.....|:.|..|..|                  :|.:.|.|.|        .:.||:.|
  Rat   343 NQFDYLAKLKSLLEGIEI------------------SNIQQRMFRP--------LINLSHIYFKK 381

  Fly   613 -HCCAFLPLVAMSSQKKTSQVQEAVLFPSDAEFDMTLWNNSMMNIWPQMHNLSKQLGASMHDPWE 676
             ..|.:.|.| .|.:..|..:                  :|:.|
  Rat   382 FQYCGYAPHV-RSCKPNTDGI------------------SSLEN--------------------- 406

  Fly   677 TAINFNEEQLQTQTGGQIATSYMEEYFEEHDVSGPATGYGFGTGLFSGMSTEDFQPGSVQCLPMP 741
                             :..|.::..|
  Rat   407 -----------------LLASIIQRVF-------------------------------------- 416

  Fly   742 GPFLPCADLFDWWTLRCGVWVVFLLSLLGNGTVVFVLLCSRSKMDVPRFLVCNLAAADFFMGIYL 806
                              ||||..::..||..|:.:....||:..:....:.:|..||..||:||
  Rat   417 ------------------VWVVSAITCFGNIFVICMRPYIRSENKLHAMSIMSLCCADCLMGVYL 463

  Fly   807 GILAIVDAATLGEFRMFAIPWQMSVLCQLSGFLAVLSSELSVYTLAVITLERNYAITHAIHLNKR 871
            .::...|....||:|..|.||..||.||..|.|||||:|:||..|..:|||:...|.:.....:.
  Rat   464 FVIGAFDLKFRGEYRKHAQPWMESVHCQFMGSLAVLSTEVSVLLLTFLTLEKYICIVYPFRCLRP 528

  Fly   872 LSLKQAGYIMSVGWVFALIMALMPLVGVSDYRKF----AVCLPFET----TTGPASLTYVISLMF 928
            ...:....::.: |:...|:|..||.....::.:    .||.|..:    :|| |.:..|:..:.
  Rat   529 RKCRTVAVLIFI-WITGFIVAFAPLGNKEFFKNYYGTNGVCFPLHSEDTGSTG-AQIYSVVIFLG 591

  Fly   929 INGCAFLTLMGCYLKMYWAIRGSQAWNTNDSR-------IAKRMALLVFTDFLCWSPIAFFSITA 986
            ||..||:.::..|..|::::..|....|...:       :|||...:||||.|||.|
  Rat   592 INLVAFIIIVFSYGSMFYSVHQSTITATEIQKQVKKEMILAKRFFFIVFTDALCWIP-------- 648

  Fly   987 IFGLQLISLEQAKI-------FTVFVLPLNSCCNPFLYAIMTKQFKKDCVTLCKHFEESRVVGGG 1044
            ||.|:.:||.:.:|       ..:|:||:||..||.:|.:.|:.||:....|..::.:.|.|...
  Rat   649 IFILKFLSLIRVEIPDTITSWVVIFILPINSALNPIIYTLTTRPFKEMIHQLWYNYRQRRSVDRK 713

  Fly  1045 G 1045
            |
  Rat   714 G 714

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	3/15 (20%)
		LRR_RI	180..>383	CDD:238064	41/202 (20%)
		leucine-rich repeat	183..204	CDD:275380	5/20 (25%)
		LRR_8	203..263	CDD:290566	12/59 (20%)
		leucine-rich repeat	205..228	CDD:275380	6/22 (27%)
		leucine-rich repeat	229..252	CDD:275380	3/22 (14%)
		LRR_8	252..311	CDD:290566	8/58 (14%)
		leucine-rich repeat	253..276	CDD:275380	4/22 (18%)
		leucine-rich repeat	277..300	CDD:275380	4/22 (18%)
		LRR_8	299..359	CDD:290566	13/59 (22%)
		leucine-rich repeat	301..324	CDD:275380	1/22 (5%)
		leucine-rich repeat	325..348	CDD:275380	8/22 (36%)
		LRR_RI	327..567	CDD:238064	66/241 (27%)
		leucine-rich repeat	349..371	CDD:275380	7/21 (33%)
		LRR_8	370..425	CDD:290566	16/54 (30%)
		leucine-rich repeat	372..393	CDD:275380	4/20 (20%)
		leucine-rich repeat	394..415	CDD:275380	8/20 (40%)
		leucine-rich repeat	418..486	CDD:275380	16/69 (23%)
		leucine-rich repeat	441..464	CDD:275378	2/22 (9%)
		LRR_8	487..545	CDD:290566	17/57 (30%)
		leucine-rich repeat	487..510	CDD:275380	6/22 (27%)
		leucine-rich repeat	511..534	CDD:275380	8/22 (36%)
		LRR_8	533..589	CDD:290566	10/55 (18%)
		leucine-rich repeat	535..558	CDD:275380	6/22 (27%)
		leucine-rich repeat	559..580	CDD:275380	4/20 (20%)
		7tm_4	764..>892	CDD:304433	39/127 (31%)
		7tm_1	770..1017	CDD:278431	81/268 (30%)
Rxfp1	XP_006232570.1	LDLa	33..68	CDD:238060	4/22 (18%)
		leucine-rich repeat	134..157	CDD:275380	5/46 (11%)
		LRR_RI	138..356	CDD:238064	71/284 (25%)
		LRR_8	158..216	CDD:290566	21/78 (27%)
		leucine-rich repeat	158..181	CDD:275380	8/22 (36%)
		leucine-rich repeat	182..205	CDD:275380	8/31 (26%)
		LRR_8	205..265	CDD:290566	24/93 (26%)
		leucine-rich repeat	206..229	CDD:275380	11/34 (32%)
		leucine-rich repeat	230..254	CDD:275380	7/45 (16%)
		leucine-rich repeat	255..278	CDD:275380	7/22 (32%)
		LRR_8	278..337	CDD:290566	17/58 (29%)
		leucine-rich repeat	279..302	CDD:275380	6/22 (27%)
		leucine-rich repeat	303..326	CDD:275380	8/22 (36%)
		leucine-rich repeat	327..350	CDD:275380	6/22 (27%)
		leucine-rich repeat	351..371	CDD:275380	8/45 (18%)
		7tm_1	427..686	CDD:278431	81/268 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2087
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810