Protein Alignment rk and Rxfp1

DIOPT Version :10

• Sequence 1: NP_476702.1
• Gene: rk / 34819
• FlyBaseID: FBgn0003255
• Length: 1360
• Species: Drosophila melanogaster
• Sequence 2: XP_006232570.1
• Gene: Rxfp1 / 295144
• RGDID: 1302973
• Length: 763
• Species: Rattus norvegicus
• Alignment Length: 911
• Identity: 205/911 - (22%)
• Similarity: 335/911 - (36%)
• Gaps: 275/911 - (30%)

  Fly   163 LSCRGIGILAVPVNLPNEVVVLDLGNNNLTKLEANSFFMAPNLEELTLSDNSIINMDPNAFYGLA 227
            |.|.|:.      :..|:....:.|:||...|:.:.:|  .|..:|| |.|||
  Rat    51 LHCNGVD------DCGNQADEDNCGDNNGWSLQLDKYF--ANYYKLT-STNSI------------ 94

  Fly   228 KLKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNGNALVSLDGDCLGHLQKLRTLRLEGNLFYRIPT 292
               ......|.:.|:|........:|...:.|..|:.|:..:       :..:.|:.|....:|.
  Rat    95 ---EAETSECLVGSVPMHCLCRDLELDCDEANLRAVPSVSSN-------VTVMSLQWNFIRTLPP 149

  Fly   293 NALAGLRTLEALNLGSNLLTIINDEDFPRMPNLIVLLLKRNQIMKISAGALKNLTALKVLELDDN 357
            |:                        |....:|..|.|:.|:|..:|..|.:.|.:|..|.|..|
  Rat   150 NS------------------------FRMYHDLQKLCLQNNKIRSVSVSAFRGLHSLTKLYLSHN 190

  Fly   358 LISSLPEGLSKLSQLQELSITSNRLRWINDTELPRSMQMLDMRANPLSTISPGAFRGMSKLRKLI 422
            .|:.|..|:     .::|    :||.|            |.:..|.||.|||..|.|::.|..|:
  Rat   191 RITFLKPGV-----FEDL----HRLEW------------LIIEDNHLSRISPLTFYGLNSLILLV 234

  Fly   423 LSDVRTLRSFPELEACHALEILKLDRAGIQEVPANLCRQTPRLKSLELKTNSLKRIPNLS--SCR 485
            |.: ..|...|:                     ..||:..|||..|:.:.|.:..:.||:  ||.
  Rat   235 LMN-NALTRLPD---------------------KPLCQHMPRLHWLDFEGNRIHNLRNLTFISCN 277

  Fly   486 DLRLLDLSSNQIEKIQGKPFNGLKQLNDLLLSYNRIKALPQDAFQGIPKLQLLDLEGNEISYIHK 550
            :|.:|.:..|:|..:....|..|::|::|.|..|:|:.||.:.|:.:.:|..|::..|.|..|..
  Rat   278 NLTVLVMRKNKINHLNEHAFTHLQKLDELDLGSNKIENLPPNIFKDLKELSQLNISYNPIQKIEV 342

  Fly   551 EAFSGFTALEDLNLGNNIFPELPESGLRALLHLKTFNNPKLREFPPPDTFPRIQTLILSYAY--- 612
            ..|.....|:.|..|..|                  :|.:.|.|.|        .:.||:.|
  Rat   343 NQFDYLAKLKSLLEGIEI------------------SNIQQRMFRP--------LINLSHIYFKK 381

  Fly   613 -HCCAFLPLVAMSSQKKTSQVQEAVLFPSDAEFDMTLWNNSMMNIWPQMHNLSKQLGASMHDPWE 676
             ..|.:.|.| .|.:..|..:                  :|:.|
  Rat   382 FQYCGYAPHV-RSCKPNTDGI------------------SSLEN--------------------- 406

  Fly   677 TAINFNEEQLQTQTGGQIATSYMEEYFEEHDVSGPATGYGFGTGLFSGMSTEDFQPGSVQCLPMP 741
                             :..|.::..|
  Rat   407 -----------------LLASIIQRVF-------------------------------------- 416

  Fly   742 GPFLPCADLFDWWTLRCGVWVVFLLSLLGNGTVVFVLLCSRSKMDVPRFLVCNLAAADFFMGIYL 806
                              ||||..::..||..|:.:....||:..:....:.:|..||..||:||
  Rat   417 ------------------VWVVSAITCFGNIFVICMRPYIRSENKLHAMSIMSLCCADCLMGVYL 463

  Fly   807 GILAIVDAATLGEFRMFAIPWQMSVLCQLSGFLAVLSSELSVYTLAVITLERNYAITHAIHLNKR 871
            .::...|....||:|..|.||..||.||..|.|||||:|:||..|..:|||:...|.:.....:.
  Rat   464 FVIGAFDLKFRGEYRKHAQPWMESVHCQFMGSLAVLSTEVSVLLLTFLTLEKYICIVYPFRCLRP 528

  Fly   872 LSLKQAGYIMSVGWVFALIMALMPLVGVSDYRKF----AVCLPFET----TTGPASLTYVISLMF 928
            ...:....::.: |:...|:|..||.....::.:    .||.|..:    :|| |.:..|:..:.
  Rat   529 RKCRTVAVLIFI-WITGFIVAFAPLGNKEFFKNYYGTNGVCFPLHSEDTGSTG-AQIYSVVIFLG 591

  Fly   929 INGCAFLTLMGCYLKMYWAIRGSQAWNTNDSR-------IAKRMALLVFTDFLCWSPIAFFSITA 986
            ||..||:.::..|..|::::..|....|...:       :|||...:||||.|||.|
  Rat   592 INLVAFIIIVFSYGSMFYSVHQSTITATEIQKQVKKEMILAKRFFFIVFTDALCWIP-------- 648

  Fly   987 IFGLQLISLEQAKI-------FTVFVLPLNSCCNPFLYAIMTKQFKKDCVTLCKHFEESRVVGGG 1044
            ||.|:.:||.:.:|       ..:|:||:||..||.:|.:.|:.||:....|..::.:.|.|...
  Rat   649 IFILKFLSLIRVEIPDTITSWVVIFILPINSALNPIIYTLTTRPFKEMIHQLWYNYRQRRSVDRK 713

  Fly  1045 G 1045
            |
  Rat   714 G 714

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	LRR	<157..390	CDD:443914	47/226 (21%)
		leucine-rich repeat	158..179	CDD:275380	3/15 (20%)
		leucine-rich repeat	183..204	CDD:275380	5/20 (25%)
		leucine-rich repeat	205..228	CDD:275380	6/22 (27%)
		leucine-rich repeat	229..252	CDD:275380	3/22 (14%)
		leucine-rich repeat	253..276	CDD:275380	4/22 (18%)
		leucine-rich repeat	277..300	CDD:275380	4/22 (18%)
		LRR	292..612	CDD:443914	76/321 (24%)
		leucine-rich repeat	301..324	CDD:275380	1/22 (5%)
		leucine-rich repeat	325..348	CDD:275380	8/22 (36%)
		leucine-rich repeat	349..371	CDD:275380	7/21 (33%)
		leucine-rich repeat	372..393	CDD:275380	4/20 (20%)
		leucine-rich repeat	394..415	CDD:275380	8/20 (40%)
		leucine-rich repeat	418..486	CDD:275380	16/69 (23%)
		leucine-rich repeat	441..464	CDD:275378	2/22 (9%)
		leucine-rich repeat	487..510	CDD:275380	6/22 (27%)
		leucine-rich repeat	511..534	CDD:275380	8/22 (36%)
		leucine-rich repeat	535..558	CDD:275380	6/22 (27%)
		leucine-rich repeat	559..580	CDD:275380	4/20 (20%)
		7tmA_Glyco_hormone_R	754..1028	CDD:320264	89/295 (30%)
		TM helix 1	755..781	CDD:320264	7/25 (28%)
		TM helix 2	788..813	CDD:320264	7/24 (29%)
		TM helix 3	833..863	CDD:320264	15/29 (52%)
		TM helix 4	875..897	CDD:320264	4/21 (19%)
		TM helix 5	918..947	CDD:320264	8/28 (29%)
		TM helix 6	956..986	CDD:320264	12/36 (33%)
		TM helix 7	996..1021	CDD:320264	9/31 (29%)
Rxfp1	XP_006232570.1	LDLa	33..68	CDD:238060	4/22 (18%)
		leucine-rich repeat	134..157	CDD:275380	5/46 (11%)
		LRR	<157..>381	CDD:443914	75/292 (26%)
		leucine-rich repeat	158..181	CDD:275380	8/22 (36%)
		leucine-rich repeat	182..205	CDD:275380	8/31 (26%)
		leucine-rich repeat	206..229	CDD:275380	11/34 (32%)
		leucine-rich repeat	230..254	CDD:275380	7/45 (16%)
		leucine-rich repeat	255..278	CDD:275380	7/22 (32%)
		leucine-rich repeat	279..302	CDD:275380	6/22 (27%)
		leucine-rich repeat	303..326	CDD:275380	8/22 (36%)
		leucine-rich repeat	327..350	CDD:275380	6/22 (27%)
		leucine-rich repeat	351..371	CDD:275380	8/45 (18%)
		7tm_GPCRs	411..697	CDD:475119	90/351 (26%)
		TM helix 1	413..437	CDD:320631	8/79 (10%)
		TM helix 2	446..467	CDD:320631	7/20 (35%)
		TM helix 3	491..513	CDD:320631	11/21 (52%)
		TM helix 4	535..551	CDD:320631	3/16 (19%)
		TM helix 5	583..606	CDD:320631	6/22 (27%)
		TM helix 6	632..654	CDD:320631	14/29 (48%)
		TM helix 7	665..690	CDD:320631	8/24 (33%)