DRSC/TRiP Functional Genomics Resources

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Protein Alignment rk and FLRT1

DIOPT Version :9

Sequence 1:NP_476702.1 Gene:rk / 34819 FlyBaseID:FBgn0003255 Length:1360 Species:Drosophila melanogaster
Sequence 2:NP_001371395.1 Gene:FLRT1 / 23769 HGNCID:3760 Length:674 Species:Homo sapiens


Alignment Length:681 Identity:151/681 - (22%)
Similarity:254/681 - (37%) Gaps:173/681 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    77 ITVNRTSKSASVTPTG-IRENVMLPSADPEKEAQILYEKSLQEYHGSQLSTASTATDVIAGKRTL 140
            :.|...:.:|:.|||. :...|::.:|..:          |:::........:..|:|| ...|.
Human     1 MVVAHPTATATTTPTATVTATVVMTTATMD----------LRDWLFLCYGLIAFLTEVI-DSTTC 54

  Fly   141 HSICERWLQKHCHCTGSLEVLRLSCRGIGILAVPVNLPNEVVVLDLGNNNL----------TKLE 195
            .|:        |.|....    :.|...|:.::|.::|::...|.|.||.:          ||:.
Human    55 PSV--------CRCDNGF----IYCNDRGLTSIPADIPDDATTLYLQNNQINNAGIPQDLKTKVN 107

  Fly   196 ANSFFMAPN------------LEELTLSDNSIINMDPNAFYGLAKLKRLSLQNCGLK--SLPPQS 246
            ....::..|            |.||.|.||::..:..::...:..|::|.|.:..:.  |:...:
Human   108 VQVIYLYENDLDEFPINLPRSLRELHLQDNNVRTIARDSLARIPLLEKLHLDDNSVSTVSIEEDA 172

  Fly   247 FQGLAQLTSLQLNGNALVSLDGDCLGHLQKLRTLRLEGNLFYRIPTNALAGLRTLEALNLGSNLL 311
            |....||..|.|:.|.|.|:..   |....|..|||:.|....||.:|..||.:|..|.|..|||
Human   173 FADSKQLKLLFLSRNHLSSIPS---GLPHTLEELRLDDNRISTIPLHAFKGLNSLRRLVLDGNLL 234

  Fly   312 T--IINDEDFPRMPNLIVLLLKRNQIMKISAGALKNLTA--LKVLELDDNLISSLP-EGLSKLSQ 371
            .  .|.|:.|.|:.||..|.|.||.:    |....||.:  |:.|.|.||.||.:| ..|:|:.:
Human   235 ANQRIADDTFSRLQNLTELSLVRNSL----AAPPLNLPSAHLQKLYLQDNAISHIPYNTLAKMRE 295

  Fly   372 LQELSITSNRLRWINDTELPRSMQMLDMRANPLSTISPGAFRGMSKLRKLILSDVRTLRSFPELE 436
            |:.|.:::|.|     |.|||                 |.|..:..|.:|:      ||:.|...
Human   296 LERLDLSNNNL-----TTLPR-----------------GLFDDLGNLAQLL------LRNNPWFC 332

  Fly   437 ACHAL---EILKLDRAGIQEVPANLCRQTPRLKSLELKTNSLKRIPNLSSCRDLRLLDLSSNQIE 498
            .|:.:   :.:|. ||.:..|...:|:...:::.:.:|                   |::|...|
Human   333 GCNLMWLRDWVKA-RAAVVNVRGLMCQGPEKVRGMAIK-------------------DITSEMDE 377

  Fly   499 KIQGKPFNGLKQLNDLLLSYNRIKA-LPQDAFQGI----PKLQLLDLEGNEISYIHKEAFSGFTA 558
            ..:..|..|:........:.|...| .||.:...:    |.|:|.|                   
Human   378 CFETGPQGGVANAAAKTTASNHASATTPQGSLFTLKAKRPGLRLPD------------------- 423

  Fly   559 LEDLNLGNNI-FPELPESGLRAL-LHLKTFNNPKLR----EFPPPDTFPRIQTLILSYAYHCCAF 617
                   :|| :|.....|.:.| :|:|......:|    ...|..:| |:..|.|.::      
Human   424 -------SNIDYPMATGDGAKTLAIHVKALTADSIRITWKATLPASSF-RLSWLRLGHS------ 474

  Fly   618 LPLVAMSSQ-----KKTSQVQEAVLFPSDAEFDMTLWNNSMMNIWPQMHNLSKQLGASMHDPWET 677
             |.|...::     .||..:..|:...|.....|.....|...:..:....:|...|..:.|..|
Human   475 -PAVGSITETLVQGDKTEYLLTALEPKSTYIICMVTMETSNAYVADETPVCAKAETADSYGPTTT 538

  Fly   678 AINFNEEQ---------LQTQTGGQIATSYM 699
               .|:||         |....||.:|..::
Human   539 ---LNQEQNAGPMASLPLAGIIGGAVALVFL 566

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
rkNP_476702.1 leucine-rich repeat 158..179 CDD:275380 3/20 (15%)
LRR_RI 180..>383 CDD:238064 68/231 (29%)
leucine-rich repeat 183..204 CDD:275380 6/30 (20%)
LRR_8 203..263 CDD:290566 17/73 (23%)
leucine-rich repeat 205..228 CDD:275380 6/22 (27%)
leucine-rich repeat 229..252 CDD:275380 5/24 (21%)
LRR_8 252..311 CDD:290566 22/58 (38%)
leucine-rich repeat 253..276 CDD:275380 7/22 (32%)
leucine-rich repeat 277..300 CDD:275380 10/22 (45%)
LRR_8 299..359 CDD:290566 24/63 (38%)
leucine-rich repeat 301..324 CDD:275380 10/24 (42%)
leucine-rich repeat 325..348 CDD:275380 8/22 (36%)
LRR_RI 327..567 CDD:238064 52/250 (21%)
leucine-rich repeat 349..371 CDD:275380 10/22 (45%)
LRR_8 370..425 CDD:290566 12/54 (22%)
leucine-rich repeat 372..393 CDD:275380 7/20 (35%)
leucine-rich repeat 394..415 CDD:275380 2/20 (10%)
leucine-rich repeat 418..486 CDD:275380 12/70 (17%)
leucine-rich repeat 441..464 CDD:275378 5/25 (20%)
LRR_8 487..545 CDD:290566 13/62 (21%)
leucine-rich repeat 487..510 CDD:275380 5/22 (23%)
leucine-rich repeat 511..534 CDD:275380 4/27 (15%)
LRR_8 533..589 CDD:290566 11/57 (19%)
leucine-rich repeat 535..558 CDD:275380 3/22 (14%)
leucine-rich repeat 559..580 CDD:275380 4/21 (19%)
7tm_4 764..>892 CDD:304433
7tm_1 770..1017 CDD:278431
FLRT1NP_001371395.1 PRK15370 <58..>329 CDD:185268 85/309 (28%)
leucine-rich repeat 108..128 CDD:275380 1/19 (5%)
leucine-rich repeat 129..152 CDD:275380 6/22 (27%)
leucine-rich repeat 153..178 CDD:275380 5/24 (21%)
leucine-rich repeat 179..199 CDD:275380 7/22 (32%)
leucine-rich repeat 200..223 CDD:275380 10/22 (45%)
leucine-rich repeat 224..249 CDD:275380 10/24 (42%)
leucine-rich repeat 250..271 CDD:275380 8/24 (33%)
leucine-rich repeat 272..295 CDD:275380 10/22 (45%)
leucine-rich repeat 296..319 CDD:275380 10/44 (23%)
PCC 300..>406 CDD:188093 27/153 (18%)
FN3 441..505 CDD:214495 14/71 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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