DRSC/TRiP Functional Genomics Resources

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Protein Alignment rk and LRRN2

DIOPT Version :9

Sequence 1:NP_476702.1 Gene:rk / 34819 FlyBaseID:FBgn0003255 Length:1360 Species:Drosophila melanogaster
Sequence 2:NP_006329.2 Gene:LRRN2 / 10446 HGNCID:16914 Length:713 Species:Homo sapiens


Alignment Length:488 Identity:128/488 - (26%)
Similarity:198/488 - (40%) Gaps:115/488 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   159 EVLRLSCRGIGILAVPVNLPNEVVVLDLGNNNLTKLEANSFFMAPNLEELTLSDNSIINMDPNAF 223
            |...:.|..:.:.|||..||.....|.|.:|::.:::.:......||.||.||.||..:.....|
Human    49 EATTVDCNDLFLTAVPPALPAGTQTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDF 113

  Fly   224 YGLAKLKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNGNALVSLDGDCLGHLQKLRTLRLEGNLFY 288
            :.|.:|..|.|:...|..|...||.|||.|..|.||.|.|                        |
Human   114 HALPQLLSLHLEENQLTRLEDHSFAGLASLQELYLNHNQL------------------------Y 154

  Fly   289 RIPTNALAGLRTLEALNLGSNLLTIINDEDFPRMPNLIVLLLKRNQ---IMKISAGALKNLTALK 350
            ||...|.:||..|..|:|.||||..|:...|..:|||.:|::..|:   |:.::...|.||.:|.
Human   155 RIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLV 219

  Fly   351 VLELDDNLISSLPEGLSKLSQLQELSITSNRLRWINDTELPR-------SMQMLDMRANPLSTIS 408
            :..::...||..  .|..|..|:.||...|:|     ..:||       .::.||:..|||..:.
Human   220 LAGMNLREISDY--ALEGLQSLESLSFYDNQL-----ARVPRRALEQVPGLKFLDLNKNPLQRVG 277

  Fly   409 PGAFRGMSKLRKLILSDVRTLRSFPELEACHALEILKLDRAGIQEVPANLCRQTPRLKSLELKTN 473
            ||.|..|..|::|.|:::.              |::.:|:..:..:|                  
Human   278 PGDFANMLHLKELGLNNME--------------ELVSIDKFALVNLP------------------ 310

  Fly   474 SLKRIPNLSSCRDLRLLDLSSN-QIEKIQGKPFNGLKQLNDLLLSYNRIKALPQDAFQGIPKLQL 537
                        :|..||:::| ::..|..:.|:.|.|:..|:|:.|.:.||.|...:.:|.||.
Human   311 ------------ELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPNLQE 363

  Fly   538 LDLEGNEISYIHKEAFSGFTALEDLNLGNNI-FPELPESGLRALLHLKTFNNPKLREFPPPD--T 599
            :.|.||.|.......::..|       |..: |.| |:|.|.|               .|||  .
Human   364 VGLHGNPIRCDCVIRWANAT-------GTRVRFIE-PQSTLCA---------------EPPDLQR 405

  Fly   600 FPRIQTLILSYAYHCCAFLPLVAMSSQKKTSQV 632
            .|..:........||   |||::..|...:.||
Human   406 LPVREVPFREMTDHC---LPLISPRSFPPSLQV 435

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
rkNP_476702.1 leucine-rich repeat 158..179 CDD:275380 6/19 (32%)
LRR_RI 180..>383 CDD:238064 62/205 (30%)
leucine-rich repeat 183..204 CDD:275380 3/20 (15%)
LRR_8 203..263 CDD:290566 25/59 (42%)
leucine-rich repeat 205..228 CDD:275380 9/22 (41%)
leucine-rich repeat 229..252 CDD:275380 9/22 (41%)
LRR_8 252..311 CDD:290566 17/58 (29%)
leucine-rich repeat 253..276 CDD:275380 6/22 (27%)
leucine-rich repeat 277..300 CDD:275380 6/22 (27%)
LRR_8 299..359 CDD:290566 19/62 (31%)
leucine-rich repeat 301..324 CDD:275380 9/22 (41%)
leucine-rich repeat 325..348 CDD:275380 7/25 (28%)
LRR_RI 327..567 CDD:238064 56/250 (22%)
leucine-rich repeat 349..371 CDD:275380 5/21 (24%)
LRR_8 370..425 CDD:290566 19/61 (31%)
leucine-rich repeat 372..393 CDD:275380 7/27 (26%)
leucine-rich repeat 394..415 CDD:275380 8/20 (40%)
leucine-rich repeat 418..486 CDD:275380 6/67 (9%)
leucine-rich repeat 441..464 CDD:275378 3/22 (14%)
LRR_8 487..545 CDD:290566 20/58 (34%)
leucine-rich repeat 487..510 CDD:275380 7/23 (30%)
leucine-rich repeat 511..534 CDD:275380 6/22 (27%)
LRR_8 533..589 CDD:290566 15/56 (27%)
leucine-rich repeat 535..558 CDD:275380 6/22 (27%)
leucine-rich repeat 559..580 CDD:275380 6/21 (29%)
7tm_4 764..>892 CDD:304433
7tm_1 770..1017 CDD:278431
LRRN2NP_006329.2 leucine-rich repeat 51..69 CDD:275380 5/17 (29%)
LRR_RI 62..288 CDD:238064 79/256 (31%)
LRR 1 70..91 3/20 (15%)
leucine-rich repeat 71..94 CDD:275380 3/22 (14%)
LRR 2 94..115 9/20 (45%)
leucine-rich repeat 95..118 CDD:275380 9/22 (41%)
LRR_8 117..177 CDD:290566 27/83 (33%)
LRR 3 118..139 7/20 (35%)
leucine-rich repeat 119..142 CDD:275380 9/22 (41%)
LRR 4 142..163 10/44 (23%)
leucine-rich repeat 143..166 CDD:275380 12/46 (26%)
LRR_8 165..222 CDD:290566 19/56 (34%)
LRR 5 166..187 9/20 (45%)
leucine-rich repeat 167..190 CDD:275380 9/22 (41%)
LRR 6 190..211 5/20 (25%)
leucine-rich repeat 191..214 CDD:275380 5/22 (23%)
LRR_RI 209..>372 CDD:238064 50/213 (23%)
LRR_8 214..273 CDD:290566 17/65 (26%)
LRR 7 214..235 6/22 (27%)
leucine-rich repeat 215..238 CDD:275380 6/24 (25%)
LRR 8 238..259 7/25 (28%)
leucine-rich repeat 239..262 CDD:275380 7/27 (26%)
LRR 9 262..283 8/20 (40%)
leucine-rich repeat 263..286 CDD:275380 9/22 (41%)
LRR 10 286..305 5/32 (16%)
leucine-rich repeat 287..311 CDD:275380 6/67 (9%)
LRR_8 310..371 CDD:290566 21/90 (23%)
LRR 11 311..333 6/21 (29%)
leucine-rich repeat 312..334 CDD:275380 6/21 (29%)
LRR 12 336..357 7/20 (35%)
leucine-rich repeat 337..360 CDD:275378 6/22 (27%)
leucine-rich repeat 361..373 CDD:275378 6/11 (55%)
TPKR_C2 369..412 CDD:301599 14/65 (22%)
I-set 430..514 CDD:254352 2/6 (33%)
Ig 438..514 CDD:299845
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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