DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rk and tmtops3a

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_001269303.1	Gene:	tmtops3a / 102031125	ZFINID:	ZDB-GENE-130828-1	Length:	379	Species:	Danio rerio

Alignment Length:	305	Identity:	66/305 - (21%)
Similarity:	120/305 - (39%)	Gaps:	49/305 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   763 VFLLSLLGNGTVVFVLLCSRSKMDVPRFLVCNLAAADFFMGIYLGILAIVDAATLGEFRMFAIPW 827
            :.||..|.|..|:.|....||.......::.|::.:|..:.:: |......::..|:       |
Zfish    54 ILLLGCLNNLFVLLVFARFRSLWTPINLILLNISVSDILVCLF-GTPFSFASSLYGK-------W 110

  Fly   828 QMSVL-CQLSGFLAVLSSELSVYTLAVITLERNYAITHAIHLNKRLSLKQAGYIMSVGWVFALIM 891
            .:... |:..||...|...:|:.:|::::.||..|:..|...:.. ..::|...::..|:::|:.
Zfish   111 LLGHHGCKWYGFANSLFGIVSLMSLSILSYERYAALLRATKADVS-DFRRAWLCVAGSWLYSLLW 174

  Fly   892 ALMPLVGVSDYRKFAVCLPFETTTGP----------------ASLTYVISLMFINGCAFLTL--- 937
            .|.|.:|.|:|             ||                :|::||:.|...  |..|.|
Zfish   175 TLPPFLGWSNY-------------GPEGPGTTCSVQWHLRSTSSISYVMCLFIF--CLLLPLVLM 224

  Fly   938 MGCYLKMYWAIRGSQAWN-----TNDSRIAKRMALLVFTDFLCWSPIAFFSITAIFGLQLISLEQ 997
            :.||.|:...|:|....|     ..::.|...:..:|....|||.|....::.|.||...:....
Zfish   225 IFCYGKILLLIKGVTKINLLTAQRRENHILLMVVTMVSCYLLCWMPYGVVALLATFGRTGLITPV 289

  Fly   998 AKIFTVFVLPLNSCCNPFLYAIMTKQFKKDCVTLCKHFEESRVVG 1042
            ..|....:...::..||.:|.:...||.:..|...|...|..|.|
Zfish   290 TSIVPSVLAKSSTVVNPVIYVLFNNQFYRCFVAFLKCQGEPSVHG 334

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380
		LRR_RI	180..>383	CDD:238064
		leucine-rich repeat	183..204	CDD:275380
		LRR_8	203..263	CDD:290566
		leucine-rich repeat	205..228	CDD:275380
		leucine-rich repeat	229..252	CDD:275380
		LRR_8	252..311	CDD:290566
		leucine-rich repeat	253..276	CDD:275380
		leucine-rich repeat	277..300	CDD:275380
		LRR_8	299..359	CDD:290566
		leucine-rich repeat	301..324	CDD:275380
		leucine-rich repeat	325..348	CDD:275380
		LRR_RI	327..567	CDD:238064
		leucine-rich repeat	349..371	CDD:275380
		LRR_8	370..425	CDD:290566
		leucine-rich repeat	372..393	CDD:275380
		leucine-rich repeat	394..415	CDD:275380
		leucine-rich repeat	418..486	CDD:275380
		leucine-rich repeat	441..464	CDD:275378
		LRR_8	487..545	CDD:290566
		leucine-rich repeat	487..510	CDD:275380
		leucine-rich repeat	511..534	CDD:275380
		LRR_8	533..589	CDD:290566
		leucine-rich repeat	535..558	CDD:275380
		leucine-rich repeat	559..580	CDD:275380
		7tm_4	764..>892	CDD:304433	26/128 (20%)
		7tm_1	770..1017	CDD:278431	55/271 (20%)
tmtops3a	NP_001269303.1	7tm_1	62..309	CDD:278431	55/270 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910