Protein Alignment rk and lrrc4

DIOPT Version :10

• Sequence 1: NP_476702.1
• Gene: rk / 34819
• FlyBaseID: FBgn0003255
• Length: 1360
• Species: Drosophila melanogaster
• Sequence 2: XP_002939414.1
• Gene: lrrc4 / 100493671
• XenbaseID: XB-GENE-968937
• Length: 641
• Species: Xenopus tropicalis
• Alignment Length: 671
• Identity: 150/671 - (22%)
• Similarity: 248/671 - (36%)
• Gaps: 207/671 - (30%)

  Fly   152 CHCTGSLEVLRLSCRGIGILAVPVNLPNEVVVLDLGNNNLTKLEANSFFMAPNLEELTLSDNSII 216
            |.|:....  ::.|...|:..||..:|:....|:|..||:..::|::|....:||.|.|..|||.
 Frog    44 CSCSNQFS--KVVCTRRGLSEVPQGIPSNTRSLNLMENNIQMIQADTFRHLHHLEVLQLGRNSIR 106

  Fly   217 NMDPNAFYGLAKLKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNGN--------------ALVSLD 267
            .::..||.|||.|..|.|.:..|..:|..:|:.|::|..|.|..|              :|:.||
 Frog   107 QIEVGAFNGLASLNTLELFDNWLTVIPSGAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLMRLD 171

  Fly   268 GDCLGHLQKLRTLRLEGNLFYRIPTNALAGLRTLEALNLG-------SNLLTIINDED------- 318
               ||.|:||..:. ||         |..||..|:.||||       .||..::..|:
 Frog   172 ---LGELKKLEYIS-EG---------AFEGLYNLKYLNLGMCNIRDMPNLTPLVGLEELEISGNN 223

  Fly   319 FPR--------MPNLIVLLLKRNQIMKISAGALKNLTALKVLELDDNLISSLPEGL-SKLSQLQE 374
            ||.        :.:|..|.:..:||..|...|..:||:|..|.|..|.::|||..| :.|..|.|
 Frog   224 FPEIKPGSFHGLRSLKKLWIMNSQINTIERNAFDDLTSLVELNLAHNNVTSLPHDLFAPLKYLVE 288

  Fly   375 LSITSNR---------LRWINDTELPRSMQMLDMRANPLSTI-----SPGAFRGMSKLRKLILSD 425
            |.:..|.         |.|.....:|.:           ||.     ||...||     |.:
 Frog   289 LHLHHNPWDCDCDVLWLSWWLREYIPTN-----------STCCGRCHSPPHMRG-----KYV--- 334

  Fly   426 VRTLRSFPELEACHALEILKLDRAGIQEVPANLCRQTPRLKSLELKTNSLKRI----PNLSSCRD 486
                     :|..|::  .:.....|.:.|.:|.....|:..|:.:|:::..:    ||.:
 Frog   335 ---------VEVDHSM--FQCSAPFIMDAPRDLNISEGRMAELKCRTSAMSSVRWLLPNGT---- 384

  Fly   487 LRLLDLSSNQIEKIQGKPFNGLKQLNDLLLSYNRIKALPQDAFQGIPKLQLLDLEGN-------- 543
              :|..:||...         :..|||..|:::::  |..|.  |:....:.::.||
 Frog   385 --VLTHASNHPR---------ITILNDGTLNFSQV--LLTDT--GVYTCMVTNVAGNSNASAYLN 434

  Fly   544 -EISYIHKEAFSGFT---------ALEDLNLGNNIFPELPESG--------LRALLHLKTFNNPK 590
             ..:.::...:|.||         |.||:::   ||..:|.:.        ....:.::|...||
 Frog   435 VSTAELNTSNYSFFTTVTVETTEVAPEDISM---IFKPVPTTSTGYQPAYTTTTTVLIQTTKMPK 496

  Fly   591 LREFPPPDTFPRIQT------------------LILSYAYHCCAFLPLVAMSSQKKT-------- 629
            ....|..|...::||                  :.|..|.....|..|.....|:.|
 Frog   497 QVAVPTSDAGDKMQTSLDEVMKTTKIIIGCFVAVTLLAAAMLIVFYKLRKRHQQRSTVAAARTVE 561

  Fly   630 -SQVQE--------------AVLFPSDAEFDMTLWNNSMMNIWPQMHN----LSKQLGASMH--- 672
             .||.|              ||:.|       |:.::...|.:...|:    .:..:|.|:|
 Frog   562 IIQVDEDIPSGSPTGVSGEGAVVLP-------TIHDHMNYNTYKPAHHGAHWTANSIGNSLHSTI 619

  Fly   673 ----DPWETAINFNEEQLQTQ 689
                :|:....:..|:..:||
 Frog   620 TTISEPYIIQTHTKEKVQETQ 640

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	LRR	<157..390	CDD:443914	80/278 (29%)
		leucine-rich repeat	158..179	CDD:275380	4/20 (20%)
		leucine-rich repeat	183..204	CDD:275380	6/20 (30%)
		leucine-rich repeat	205..228	CDD:275380	11/22 (50%)
		leucine-rich repeat	229..252	CDD:275380	7/22 (32%)
		leucine-rich repeat	253..276	CDD:275380	10/36 (28%)
		leucine-rich repeat	277..300	CDD:275380	6/22 (27%)
		LRR	292..612	CDD:443914	83/404 (21%)
		leucine-rich repeat	301..324	CDD:275380	10/44 (23%)
		leucine-rich repeat	325..348	CDD:275380	7/22 (32%)
		leucine-rich repeat	349..371	CDD:275380	9/22 (41%)
		leucine-rich repeat	372..393	CDD:275380	7/29 (24%)
		leucine-rich repeat	394..415	CDD:275380	5/25 (20%)
		leucine-rich repeat	418..486	CDD:275380	11/71 (15%)
		leucine-rich repeat	441..464	CDD:275378	3/22 (14%)
		leucine-rich repeat	487..510	CDD:275380	3/22 (14%)
		leucine-rich repeat	511..534	CDD:275380	7/22 (32%)
		leucine-rich repeat	535..558	CDD:275380	5/40 (13%)
		leucine-rich repeat	559..580	CDD:275380	5/28 (18%)
		7tmA_Glyco_hormone_R	754..1028	CDD:320264
		TM helix 1	755..781	CDD:320264
		TM helix 2	788..813	CDD:320264
		TM helix 3	833..863	CDD:320264
		TM helix 4	875..897	CDD:320264
		TM helix 5	918..947	CDD:320264
		TM helix 6	956..986	CDD:320264
		TM helix 7	996..1021	CDD:320264
lrrc4	XP_002939414.1	LRRNT	40..71	CDD:214470	7/28 (25%)
		LRR	<69..>295	CDD:443914	72/238 (30%)
		leucine-rich repeat	71..94	CDD:275380	6/22 (27%)
		leucine-rich repeat	95..118	CDD:275380	11/22 (50%)
		leucine-rich repeat	119..142	CDD:275380	7/22 (32%)
		leucine-rich repeat	143..166	CDD:275380	4/22 (18%)
		leucine-rich repeat	167..191	CDD:275380	13/36 (36%)
		leucine-rich repeat	192..213	CDD:275380	7/20 (35%)
		leucine-rich repeat	214..237	CDD:275380	3/22 (14%)
		leucine-rich repeat	238..261	CDD:275380	7/22 (32%)
		leucine-rich repeat	262..283	CDD:275380	8/20 (40%)
		LRRCT	294..345	CDD:214507	13/80 (16%)
		IG_like	353..435	CDD:214653	19/100 (19%)
		Ig strand B	364..368	CDD:409353	1/3 (33%)
		Ig strand C	376..379	CDD:409353	0/2 (0%)
		Ig strand E	402..405	CDD:409353	1/2 (50%)
		Ig strand F	415..420	CDD:409353	0/4 (0%)
		Ig strand G	428..431	CDD:409353	0/2 (0%)