DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rk and lrrc4

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	XP_002939414.1	Gene:	lrrc4 / 100493671	XenbaseID:	XB-GENE-968937	Length:	641	Species:	Xenopus tropicalis

Alignment Length:	503	Identity:	119/503 - (23%)
Similarity:	188/503 - (37%)	Gaps:	147/503 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   290 IPTNALAGLRTLEALNLGSNLLTIINDEDFPRMPNLIVLLLKRNQIMKISAGALKNLTALKVLEL 354
            ||:|.       .:|||..|.:.:|..:.|..:.:|.||.|.||.|.:|..||...|.:|..|||
Frog    67 IPSNT-------RSLNLMENNIQMIQADTFRHLHHLEVLQLGRNSIRQIEVGAFNGLASLNTLEL 124

  Fly   355 DDNLISSLPEG-LSKLSQLQELSITSNRLRWINDTELPRSMQMLDMRANPLSTISPGAFRGMSKL 418
            .||.::.:|.| ...||:|:||        |              :|.||:.:|...||..:..|
Frog   125 FDNWLTVIPSGAFEYLSKLREL--------W--------------LRNNPIESIPSYAFNRVPSL 167

  Fly   419 RKLILSDVRTLRSFPE--LEACHALEILKLDRAGIQEVPANLCRQTPRLKSLELKTNSLKRIPNL 481
            .:|.|.:::.|....|  .|..:.|:.|.|....|::                        :|||
Frog   168 MRLDLGELKKLEYISEGAFEGLYNLKYLNLGMCNIRD------------------------MPNL 208

  Fly   482 SSCRDLRLLDLSSNQIEKIQGKPFNGLKQLNDLLLSYNRIKALPQDAFQGIPKLQLLDLEGNEIS 546
            :....|..|::|.|...:|:...|:||:.|.                     ||.:::   ::|:
Frog   209 TPLVGLEELEISGNNFPEIKPGSFHGLRSLK---------------------KLWIMN---SQIN 249

  Fly   547 YIHKEAFSGFTALEDLNLGNNIFPELPE---SGLRALLHLKTFNNP------------KLREFPP 596
            .|.:.||...|:|.:|||.:|....||.   :.|:.|:.|...:||            .|||:.|
Frog   250 TIERNAFDDLTSLVELNLAHNNVTSLPHDLFAPLKYLVELHLHHNPWDCDCDVLWLSWWLREYIP 314

  Fly   597 PDTFPRIQTLILSYAYHCCAFLPLVAMSSQKKTSQVQEAVL-----FPSDAEFDMTLWNNSMMNI 656
            .::             .||...........|...:|..::.     |..||..|:.:....|..:
Frog   315 TNS-------------TCCGRCHSPPHMRGKYVVEVDHSMFQCSAPFIMDAPRDLNISEGRMAEL 366

  Fly   657 -----------WPQMHNLSKQLGASMHDPWETAIN---FNEEQ-LQTQT-----------GGQIA 695
                       | .:.|.:....||.| |..|.:|   .|..| |.|.|           |...|
Frog   367 KCRTSAMSSVRW-LLPNGTVLTHASNH-PRITILNDGTLNFSQVLLTDTGVYTCMVTNVAGNSNA 429

  Fly   696 TSYMEEYFEEHDVSGPATGYGFGTGLFSGMSTEDFQPGSVQCLPMPGP 743
            ::|:.....|.:.|    .|.|.|.:  .:.|.:..|..:..:..|.|
Frog   430 SAYLNVSTAELNTS----NYSFFTTV--TVETTEVAPEDISMIFKPVP 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380
		LRR_RI	180..>383	CDD:238064	33/93 (35%)
		leucine-rich repeat	183..204	CDD:275380
		LRR_8	203..263	CDD:290566
		leucine-rich repeat	205..228	CDD:275380
		leucine-rich repeat	229..252	CDD:275380
		LRR_8	252..311	CDD:290566	7/20 (35%)
		leucine-rich repeat	253..276	CDD:275380
		leucine-rich repeat	277..300	CDD:275380	3/9 (33%)
		LRR_8	299..359	CDD:290566	23/59 (39%)
		leucine-rich repeat	301..324	CDD:275380	6/22 (27%)
		leucine-rich repeat	325..348	CDD:275380	11/22 (50%)
		LRR_RI	327..567	CDD:238064	63/242 (26%)
		leucine-rich repeat	349..371	CDD:275380	9/22 (41%)
		LRR_8	370..425	CDD:290566	14/54 (26%)
		leucine-rich repeat	372..393	CDD:275380	4/20 (20%)
		leucine-rich repeat	394..415	CDD:275380	6/20 (30%)
		leucine-rich repeat	418..486	CDD:275380	13/69 (19%)
		leucine-rich repeat	441..464	CDD:275378	4/22 (18%)
		LRR_8	487..545	CDD:290566	11/57 (19%)
		leucine-rich repeat	487..510	CDD:275380	8/22 (36%)
		leucine-rich repeat	511..534	CDD:275380	1/22 (5%)
		LRR_8	533..589	CDD:290566	17/58 (29%)
		leucine-rich repeat	535..558	CDD:275380	5/22 (23%)
		leucine-rich repeat	559..580	CDD:275380	8/23 (35%)
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
lrrc4	XP_002939414.1	LRRNT	40..71	CDD:214470	2/3 (67%)
		LRR	<68..285	CDD:227223	76/293 (26%)
		leucine-rich repeat	71..94	CDD:275380	6/29 (21%)
		leucine-rich repeat	95..118	CDD:275380	11/22 (50%)
		leucine-rich repeat	119..142	CDD:275380	9/22 (41%)
		leucine-rich repeat	143..166	CDD:275380	10/44 (23%)
		leucine-rich repeat	167..191	CDD:275380	6/23 (26%)
		leucine-rich repeat	192..213	CDD:275380	7/44 (16%)
		leucine-rich repeat	214..237	CDD:275380	8/22 (36%)
		leucine-rich repeat	238..261	CDD:275380	7/46 (15%)
		leucine-rich repeat	262..283	CDD:275380	7/20 (35%)
		LRRCT	294..345	CDD:214507	10/63 (16%)
		IG_like	353..435	CDD:214653	18/83 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910