DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rk and adra1a

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	XP_002933012.2	Gene:	adra1a / 100492776	XenbaseID:	XB-GENE-6048410	Length:	489	Species:	Xenopus tropicalis

Alignment Length:	450	Identity:	90/450 - (20%)
Similarity:	159/450 - (35%)	Gaps:	134/450 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   759 GVWVVFLLSLLGNGTVVFVLLCSRSKMDVPRFLVCNLAAADFFMGIYLGILAIVDAATLGEFRMF 823
            ||::.|  .:|||..|:..:.|.|....|..:.:.|||.||    :.|..:.:..:||      |
Frog    58 GVFITF--GVLGNILVILSVACHRHLQTVTHYFIANLAVAD----LLLMSMVLPFSAT------F 110

  Fly   824 AIP--WQMS-VLCQLSGFLAVLSSELSVYTLAVITLERNYAITHAIHLNKRLSLKQAGYIMSVGW 885
            .|.  |... :.|.:...:.||....|:.:|..|:::|...:::.:.....::.|:....:...|
Frog   111 EIQGYWLFGRIFCNIWAAVDVLCCTASIMSLCAISIDRYIGVSYPLRYPSIMTEKRGVLALLCIW 175

  Fly   886 VFALIMALMPLVGVSDYRKFA-----VCLPFETTTGPASLTYVISLMFINGCAFLTL---MGCYL 942
            |.:|::::.||.|   :::.|     :|   |.|..|.   |.:...|  |..:|.|   :..|.
Frog   176 VLSLVISIGPLFG---WKQPAPEDDKIC---EITKEPG---YALFSAF--GSFYLPLSIILVMYF 229

  Fly   943 KMYWAIR---------------------------------GSQAWN-------------TNDSRI 961
            ::|...:                                 ||.:.:             :.:.:.
Frog   230 RVYIVAKRESKVLTSGMKLEKSDSEEVTLRIHRKSTPESIGSTSSSKQKTQFSVRLLKFSREKKA 294

  Fly   962 AKRMALLVFTDFLCWSPIAFFSITAIFGLQLISLEQAKIF--TVFVLPLNSCCNPFLYAIMTKQF 1024
            ||.:.::|....|||.|  ||.:..|..:...:.....||  |.::...|||.||.:|...:.:|
Frog   295 AKTLGIVVGCFVLCWLP--FFLVMPIGSIYPPANSSDTIFKITFWLGYFNSCINPVIYPCSSPEF 357

  Fly  1025 KKDCVTL----CKHFEESRVVGGGG--------------------PGGRG----AVARTKRG--- 1058
            :|....:    |.|..::......|                    |.|.|    .::::..|
Frog   358 RKAFQNILHARCSHRRQAASKYSSGFLLNSPVHRSSEENKNVVRIPVGSGEMFYRISKSDEGCEW 422

  Fly  1059 ----DLPPPLLPAAAVAHPPGCRCLRMLPSEMPNWHKMEQTPSMWQRLRTFCCGENRRRR 1114
                .||.|..|.........|...|:               |....|||.||...::.|
Frog   423 KYFTPLPSPATPYGTPRDFANCSSARV---------------SSKSFLRTCCCVGTQQTR 467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380
		LRR_RI	180..>383	CDD:238064
		leucine-rich repeat	183..204	CDD:275380
		LRR_8	203..263	CDD:290566
		leucine-rich repeat	205..228	CDD:275380
		leucine-rich repeat	229..252	CDD:275380
		LRR_8	252..311	CDD:290566
		leucine-rich repeat	253..276	CDD:275380
		leucine-rich repeat	277..300	CDD:275380
		LRR_8	299..359	CDD:290566
		leucine-rich repeat	301..324	CDD:275380
		leucine-rich repeat	325..348	CDD:275380
		LRR_RI	327..567	CDD:238064
		leucine-rich repeat	349..371	CDD:275380
		LRR_8	370..425	CDD:290566
		leucine-rich repeat	372..393	CDD:275380
		leucine-rich repeat	394..415	CDD:275380
		leucine-rich repeat	418..486	CDD:275380
		leucine-rich repeat	441..464	CDD:275378
		LRR_8	487..545	CDD:290566
		leucine-rich repeat	487..510	CDD:275380
		leucine-rich repeat	511..534	CDD:275380
		LRR_8	533..589	CDD:290566
		leucine-rich repeat	535..558	CDD:275380
		leucine-rich repeat	559..580	CDD:275380
		7tm_4	764..>892	CDD:304433	30/130 (23%)
		7tm_1	770..1017	CDD:278431	63/305 (21%)
adra1a	XP_002933012.2	7tmA_alpha1A_AR	51..361	CDD:320448	70/327 (21%)
		TM helix 1	52..78	CDD:320448	7/21 (33%)
		TM helix 2	85..111	CDD:320448	8/35 (23%)
		TM helix 3	123..153	CDD:320448	7/29 (24%)
		TM helix 4	165..188	CDD:320448	6/22 (27%)
		TM helix 5	205..234	CDD:320448	8/33 (24%)
		TM helix 6	289..319	CDD:320448	9/31 (29%)
		TM helix 7	329..354	CDD:320448	9/24 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910