DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rk and lgr5

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	XP_002940219.2	Gene:	lgr5 / 100486389	XenbaseID:	XB-GENE-994091	Length:	902	Species:	Xenopus tropicalis

Alignment Length:	901	Identity:	256/901 - (28%)
Similarity:	413/901 - (45%)	Gaps:	127/901 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   152 CHCTGSLEVLRLSCRGIGILAVPVNLPNEVVVLDLGNNNLTKLEANSFFMAPNLEELTLSDNSII 216
            |.|.....::|:.|....:.::|.||......|||..||:|.|.:|.......||||.|:.|.:.
Frog    36 CECEQEGMLVRVDCSDRALTSLPRNLSIFTSYLDLSMNNITNLPSNVMHNLHFLEELRLAGNDLT 100

  Fly   217 NMDPNAFYGLAKLKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNGNALVSLDGDCLGHLQKLRTLR 281
            .:...||.||..||.|.|||..|:.:|.::...|..|.||:|:.|.:..:.......|..||.|.
Frog   101 YIPKGAFAGLGSLKVLMLQNNLLRQVPSEALHNLRSLQSLRLDANHISYVPPSSFNGLFSLRHLW 165

  Fly   282 LEGNLFYRIPTNALAGLRTLEALNLGSNLLTIINDEDFPRMPNLIVLLLKRNQIMKISAGALKNL 346
            |:.|....||..||..|..|:|:.|..|.:..|.|..|..:.:|:||.|..|:|..:.......|
Frog   166 LDDNSLTEIPVRALESLSALQAMTLALNKIHHIPDYAFRNLSSLVVLHLHNNRIYSLGKKCFDGL 230

  Fly   347 TALKVLELDDNLISSLPEGLSKLSQLQELSITSNRLRWINDTELPRSMQMLDMR--ANPLSTISP 409
            .:|:.|:|:.|.:...|..:..|..|:||...||.::.|.:.....:..::.:.  .||:..:..
Frog   231 HSLETLDLNYNNLDEFPAAIKTLKNLKELGFHSNNIKSIPEQAFIGNPSLITIHFYDNPIQHVGR 295

  Fly   410 GAFRGMSKLRKLILSDVRTLRSFPELEACHALEILKLDRAGIQEVPANLCRQTPRLKSLELKTNS 474
            .||:.:.:||.|||:....:..||:|....:||.|.|..|.:..:|:.:|.|.|.|:.|:|..|.
Frog   296 SAFQHLPELRTLILNGASQITEFPDLTGTTSLESLTLTGAQLVYLPSAVCTQLPNLQVLDLSYNH 360

  Fly   475 LKRIPNLSSCRDLRLLDLSSNQIEKIQGKPFNGLKQLNDLLLSYNRIKALPQDAFQGIPKLQLLD 539
            :|.:|:.|.|:.|:.:||..|::.:|:                        ...||.:..|:.||
Frog   361 IKDLPSFSGCQRLQKIDLRHNEVYEIR------------------------STTFQQLVGLRSLD 401

  Fly   540 LEGNEISYIHKEAFSGFTALEDLNLGNNIFPELPESGLRALLHLKTFNNPKLREFPPPDTFPRIQ 604
            |..|:|:.||..:||...:|..|:|.:|.....|.:||..|.|||...|..|::..|.:.||:::
Frog   402 LAWNKIAVIHPNSFSSLPSLIKLDLSSNHLTSFPVTGLHGLTHLKLTGNSALQDLIPSEHFPKLR 466

  Fly   605 TLILSYAYHCCAFLPLVAMSSQKKTSQVQEAVLFPSDAEFDMTLWNNSMMNIWPQMHNLSKQLGA 669
            .:.:.|||.||||   ....:.|.:.|                               ::|...:
Frog   467 VMEMPYAYQCCAF---AVCDNLKHSGQ-------------------------------MNKDENS 497

  Fly   670 SMHDPWETAINFNEEQLQTQTGGQIATSYMEEYFEEHDVSGPATGYGFGTGLFSGMSTEDFQP-- 732
            |..|                             |...|:           ||.......||:.
Frog   498 SADD-----------------------------FYRKDI-----------GLLHLQDDRDFEDFL 522

  Fly   733 ----------GSVQCLPMPGPFLPCADLFDWWTLRCGVWVVFLLSLLGNGTVVFVLLCSRSKMDV 787
                      .||||.|..|||.||..||..|..|.|||::.|||.:.|..|:..:....|.:..
Frog   523 LDFEEDVKVLHSVQCTPSAGPFKPCDHLFGSWLTRTGVWLIVLLSFVCNALVIATVFRPLSYVPS 587

  Fly   788 PRFLVCNLAAADFFMGIYLGILAIVDAATLGEFRMFAIPWQMSVLCQLSGFLAVLSSELSVYTLA 852
            .:.|:..:|..:..||:..|:||.|||.|.|.|..:...|:..|.||::|||:|.::|.|::.|.
Frog   588 IKLLIGLIAIMNTLMGLSSGVLATVDALTFGNFAQYGAWWESGVGCQITGFLSVFAAETSIFLLT 652

  Fly   853 VITLERNYAI-------THAIHLNKRLSLKQAGYIMSVGWVFALIMALMPLVGVSDYRKFAVCLP 910
            |..|||.::|       |.:..:|.:||:...       ::.::::|:.||:..|.|....:|.|
Frog   653 VAALERGFSIKCTTKFETKSSFINVKLSIVFC-------FLLSIVIAVSPLLSGSTYGTSPLCFP 710

  Fly   911 FETTTGPASLTYVISLMFINGCAFLTLMGCYLKMYWAIRGSQAWNTNDSRIAKRMALLVFTDFLC 975
            . ....|:|:.::::|:.:|...||.:...|.|:|.::...:..|..|..:.|.:|||:||:.:.
Frog   711 L-LFGDPSSMGFMVALVLLNSLCFLVMTIAYTKLYCSLEKGELENIWDCSMVKHIALLLFTNCIL 774

  Fly   976 WSPIAFFSITAIFGLQLISLEQAKIFTVFVLPLNSCCNPFLYAIMTKQFKKDCVTL 1031
            :.|:||.|.:::..|..||.|..|...:.::||.:|.||.||.:....||:|..:|
Frog   775 YCPVAFLSFSSLLNLTFISPEVNKSILLLIIPLPACLNPLLYILFNPHFKEDIGSL 830

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	5/20 (25%)
		LRR_RI	180..>383	CDD:238064	68/202 (34%)
		leucine-rich repeat	183..204	CDD:275380	8/20 (40%)
		LRR_8	203..263	CDD:290566	24/59 (41%)
		leucine-rich repeat	205..228	CDD:275380	10/22 (45%)
		leucine-rich repeat	229..252	CDD:275380	9/22 (41%)
		LRR_8	252..311	CDD:290566	20/58 (34%)
		leucine-rich repeat	253..276	CDD:275380	6/22 (27%)
		leucine-rich repeat	277..300	CDD:275380	10/22 (45%)
		LRR_8	299..359	CDD:290566	18/59 (31%)
		leucine-rich repeat	301..324	CDD:275380	7/22 (32%)
		leucine-rich repeat	325..348	CDD:275380	7/22 (32%)
		LRR_RI	327..567	CDD:238064	67/241 (28%)
		leucine-rich repeat	349..371	CDD:275380	6/21 (29%)
		LRR_8	370..425	CDD:290566	15/56 (27%)
		leucine-rich repeat	372..393	CDD:275380	6/20 (30%)
		leucine-rich repeat	394..415	CDD:275380	4/22 (18%)
		leucine-rich repeat	418..486	CDD:275380	25/67 (37%)
		leucine-rich repeat	441..464	CDD:275378	8/22 (36%)
		LRR_8	487..545	CDD:290566	12/57 (21%)
		leucine-rich repeat	487..510	CDD:275380	5/22 (23%)
		leucine-rich repeat	511..534	CDD:275380	2/22 (9%)
		LRR_8	533..589	CDD:290566	21/55 (38%)
		leucine-rich repeat	535..558	CDD:275380	10/22 (45%)
		leucine-rich repeat	559..580	CDD:275380	7/20 (35%)
		7tm_4	764..>892	CDD:304433	39/134 (29%)
		7tm_1	770..1017	CDD:278431	74/253 (29%)
lgr5	XP_002940219.2	LRRNT	32..>61	CDD:214470	5/24 (21%)
		PLN00113	56..>449	CDD:215061	129/416 (31%)
		leucine-rich repeat	65..88	CDD:275380	8/22 (36%)
		leucine-rich repeat	89..112	CDD:275380	10/22 (45%)
		leucine-rich repeat	113..136	CDD:275380	9/22 (41%)
		leucine-rich repeat	137..160	CDD:275380	6/22 (27%)
		leucine-rich repeat	161..184	CDD:275380	10/22 (45%)
		leucine-rich repeat	185..208	CDD:275380	7/22 (32%)
		leucine-rich repeat	209..232	CDD:275380	7/22 (32%)
		leucine-rich repeat	233..255	CDD:275380	6/21 (29%)
		leucine-rich repeat	256..279	CDD:275380	6/22 (27%)
		leucine-rich repeat	280..301	CDD:275380	4/20 (20%)
		leucine-rich repeat	327..350	CDD:275378	8/22 (36%)
		leucine-rich repeat	351..372	CDD:275378	8/20 (40%)
		leucine-rich repeat	373..396	CDD:275378	7/46 (15%)
		leucine-rich repeat	397..420	CDD:275378	10/22 (45%)
		leucine-rich repeat	421..433	CDD:275378	4/11 (36%)
		7tm_GPCRs	554..827	CDD:391938	86/280 (31%)
		TM helix 1	556..580	CDD:341315	9/23 (39%)
		TM helix 2	589..610	CDD:341315	5/20 (25%)
		TM helix 3	634..656	CDD:341315	9/21 (43%)
		TM helix 4	679..695	CDD:341315	3/22 (14%)
		TM helix 5	719..742	CDD:341315	5/22 (23%)
		TM helix 6	758..783	CDD:341315	9/24 (38%)
		TM helix 7	795..820	CDD:341315	9/24 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	95	1.000	Domainoid score	I7300
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20807
Inparanoid	1	1.050	416	1.000	Inparanoid score	I1776
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D171884at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.970