DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment rk and lgr5

DIOPT Version :10

Sequence 1:NP_476702.1 Gene:rk / 34819 FlyBaseID:FBgn0003255 Length:1360 Species:Drosophila melanogaster
Sequence 2:XP_002940219.2 Gene:lgr5 / 100486389 XenbaseID:XB-GENE-994091 Length:902 Species:Xenopus tropicalis


Alignment Length:901 Identity:256/901 - (28%)
Similarity:413/901 - (45%) Gaps:127/901 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly   152 CHCTGSLEVLRLSCRGIGILAVPVNLPNEVVVLDLGNNNLTKLEANSFFMAPNLEELTLSDNSII 216
            |.|.....::|:.|....:.::|.||......|||..||:|.|.:|.......||||.|:.|.:.
 Frog    36 CECEQEGMLVRVDCSDRALTSLPRNLSIFTSYLDLSMNNITNLPSNVMHNLHFLEELRLAGNDLT 100

  Fly   217 NMDPNAFYGLAKLKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNGNALVSLDGDCLGHLQKLRTLR 281
            .:...||.||..||.|.|||..|:.:|.::...|..|.||:|:.|.:..:.......|..||.|.
 Frog   101 YIPKGAFAGLGSLKVLMLQNNLLRQVPSEALHNLRSLQSLRLDANHISYVPPSSFNGLFSLRHLW 165

  Fly   282 LEGNLFYRIPTNALAGLRTLEALNLGSNLLTIINDEDFPRMPNLIVLLLKRNQIMKISAGALKNL 346
            |:.|....||..||..|..|:|:.|..|.:..|.|..|..:.:|:||.|..|:|..:.......|
 Frog   166 LDDNSLTEIPVRALESLSALQAMTLALNKIHHIPDYAFRNLSSLVVLHLHNNRIYSLGKKCFDGL 230

  Fly   347 TALKVLELDDNLISSLPEGLSKLSQLQELSITSNRLRWINDTELPRSMQMLDMR--ANPLSTISP 409
            .:|:.|:|:.|.:...|..:..|..|:||...||.::.|.:.....:..::.:.  .||:..:..
 Frog   231 HSLETLDLNYNNLDEFPAAIKTLKNLKELGFHSNNIKSIPEQAFIGNPSLITIHFYDNPIQHVGR 295

  Fly   410 GAFRGMSKLRKLILSDVRTLRSFPELEACHALEILKLDRAGIQEVPANLCRQTPRLKSLELKTNS 474
            .||:.:.:||.|||:....:..||:|....:||.|.|..|.:..:|:.:|.|.|.|:.|:|..|.
 Frog   296 SAFQHLPELRTLILNGASQITEFPDLTGTTSLESLTLTGAQLVYLPSAVCTQLPNLQVLDLSYNH 360

  Fly   475 LKRIPNLSSCRDLRLLDLSSNQIEKIQGKPFNGLKQLNDLLLSYNRIKALPQDAFQGIPKLQLLD 539
            :|.:|:.|.|:.|:.:||..|::.:|:                        ...||.:..|:.||
 Frog   361 IKDLPSFSGCQRLQKIDLRHNEVYEIR------------------------STTFQQLVGLRSLD 401

  Fly   540 LEGNEISYIHKEAFSGFTALEDLNLGNNIFPELPESGLRALLHLKTFNNPKLREFPPPDTFPRIQ 604
            |..|:|:.||..:||...:|..|:|.:|.....|.:||..|.|||...|..|::..|.:.||:::
 Frog   402 LAWNKIAVIHPNSFSSLPSLIKLDLSSNHLTSFPVTGLHGLTHLKLTGNSALQDLIPSEHFPKLR 466

  Fly   605 TLILSYAYHCCAFLPLVAMSSQKKTSQVQEAVLFPSDAEFDMTLWNNSMMNIWPQMHNLSKQLGA 669
            .:.:.|||.||||   ....:.|.:.|                               ::|...:
 Frog   467 VMEMPYAYQCCAF---AVCDNLKHSGQ-------------------------------MNKDENS 497

  Fly   670 SMHDPWETAINFNEEQLQTQTGGQIATSYMEEYFEEHDVSGPATGYGFGTGLFSGMSTEDFQP-- 732
            |..|                             |...|:           ||.......||:.  
 Frog   498 SADD-----------------------------FYRKDI-----------GLLHLQDDRDFEDFL 522

  Fly   733 ----------GSVQCLPMPGPFLPCADLFDWWTLRCGVWVVFLLSLLGNGTVVFVLLCSRSKMDV 787
                      .||||.|..|||.||..||..|..|.|||::.|||.:.|..|:..:....|.:..
 Frog   523 LDFEEDVKVLHSVQCTPSAGPFKPCDHLFGSWLTRTGVWLIVLLSFVCNALVIATVFRPLSYVPS 587

  Fly   788 PRFLVCNLAAADFFMGIYLGILAIVDAATLGEFRMFAIPWQMSVLCQLSGFLAVLSSELSVYTLA 852
            .:.|:..:|..:..||:..|:||.|||.|.|.|..:...|:..|.||::|||:|.::|.|::.|.
 Frog   588 IKLLIGLIAIMNTLMGLSSGVLATVDALTFGNFAQYGAWWESGVGCQITGFLSVFAAETSIFLLT 652

  Fly   853 VITLERNYAI-------THAIHLNKRLSLKQAGYIMSVGWVFALIMALMPLVGVSDYRKFAVCLP 910
            |..|||.::|       |.:..:|.:||:...       ::.::::|:.||:..|.|....:|.|
 Frog   653 VAALERGFSIKCTTKFETKSSFINVKLSIVFC-------FLLSIVIAVSPLLSGSTYGTSPLCFP 710

  Fly   911 FETTTGPASLTYVISLMFINGCAFLTLMGCYLKMYWAIRGSQAWNTNDSRIAKRMALLVFTDFLC 975
            . ....|:|:.::::|:.:|...||.:...|.|:|.::...:..|..|..:.|.:|||:||:.:.
 Frog   711 L-LFGDPSSMGFMVALVLLNSLCFLVMTIAYTKLYCSLEKGELENIWDCSMVKHIALLLFTNCIL 774

  Fly   976 WSPIAFFSITAIFGLQLISLEQAKIFTVFVLPLNSCCNPFLYAIMTKQFKKDCVTL 1031
            :.|:||.|.:::..|..||.|..|...:.::||.:|.||.||.:....||:|..:|
 Frog   775 YCPVAFLSFSSLLNLTFISPEVNKSILLLIIPLPACLNPLLYILFNPHFKEDIGSL 830

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
rkNP_476702.1 LRR <157..390 CDD:443914 74/232 (32%)
leucine-rich repeat 158..179 CDD:275380 5/20 (25%)
leucine-rich repeat 183..204 CDD:275380 8/20 (40%)
leucine-rich repeat 205..228 CDD:275380 10/22 (45%)
leucine-rich repeat 229..252 CDD:275380 9/22 (41%)
leucine-rich repeat 253..276 CDD:275380 6/22 (27%)
leucine-rich repeat 277..300 CDD:275380 10/22 (45%)
LRR 292..612 CDD:443914 92/321 (29%)
leucine-rich repeat 301..324 CDD:275380 7/22 (32%)
leucine-rich repeat 325..348 CDD:275380 7/22 (32%)
leucine-rich repeat 349..371 CDD:275380 6/21 (29%)
leucine-rich repeat 372..393 CDD:275380 6/20 (30%)
leucine-rich repeat 394..415 CDD:275380 4/22 (18%)
leucine-rich repeat 418..486 CDD:275380 25/67 (37%)
leucine-rich repeat 441..464 CDD:275378 8/22 (36%)
leucine-rich repeat 487..510 CDD:275380 5/22 (23%)
leucine-rich repeat 511..534 CDD:275380 2/22 (9%)
leucine-rich repeat 535..558 CDD:275380 10/22 (45%)
leucine-rich repeat 559..580 CDD:275380 7/20 (35%)
7tmA_Glyco_hormone_R 754..1028 CDD:320264 86/280 (31%)
TM helix 1 755..781 CDD:320264 9/25 (36%)
TM helix 2 788..813 CDD:320264 7/24 (29%)
TM helix 3 833..863 CDD:320264 14/36 (39%)
TM helix 4 875..897 CDD:320264 2/21 (10%)
TM helix 5 918..947 CDD:320264 8/28 (29%)
TM helix 6 956..986 CDD:320264 11/29 (38%)
TM helix 7 996..1021 CDD:320264 9/24 (38%)
lgr5XP_002940219.2 LRRNT 32..>61 CDD:214470 5/24 (21%)
leucine-rich repeat 65..88 CDD:275380 8/22 (36%)
LRR 89..459 CDD:443914 120/393 (31%)
leucine-rich repeat 89..112 CDD:275380 10/22 (45%)
leucine-rich repeat 113..136 CDD:275380 9/22 (41%)
leucine-rich repeat 137..160 CDD:275380 6/22 (27%)
leucine-rich repeat 161..184 CDD:275380 10/22 (45%)
leucine-rich repeat 185..208 CDD:275380 7/22 (32%)
leucine-rich repeat 209..232 CDD:275380 7/22 (32%)
leucine-rich repeat 233..255 CDD:275380 6/21 (29%)
leucine-rich repeat 256..279 CDD:275380 6/22 (27%)
leucine-rich repeat 280..301 CDD:275380 4/20 (20%)
leucine-rich repeat 327..350 CDD:275378 8/22 (36%)
leucine-rich repeat 351..372 CDD:275378 8/20 (40%)
leucine-rich repeat 373..396 CDD:275378 7/46 (15%)
leucine-rich repeat 397..420 CDD:275378 10/22 (45%)
leucine-rich repeat 421..433 CDD:275378 4/11 (36%)
7tm_GPCRs 554..827 CDD:475119 86/280 (31%)
TM helix 1 556..580 CDD:410628 9/23 (39%)
TM helix 2 589..610 CDD:410628 5/20 (25%)
TM helix 3 634..656 CDD:410628 9/21 (43%)
TM helix 4 679..695 CDD:410628 3/22 (14%)
TM helix 5 719..742 CDD:410628 5/22 (23%)
TM helix 6 761..783 CDD:410628 9/21 (43%)
TM helix 7 795..820 CDD:410628 9/24 (38%)

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