DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rk and dcn

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_001093704.1	Gene:	dcn / 100101716	XenbaseID:	XB-GENE-485545	Length:	364	Species:	Xenopus tropicalis

Alignment Length:	422	Identity:	98/422 - (23%)
Similarity:	160/422 - (37%)	Gaps:	129/422 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   152 CHCTGSLEVLRLSCRGIGILAVPVNLPNEVVVLDLGNNNLTKLEANSFFMAPNLEELTLSDNSII 216
            |.|  .|.|::  |..||:..||.::|::..:|||.||.:|:::...|....||..|.|.:|.|.
Frog    63 CQC--HLRVVQ--CSDIGLEQVPKDIPSDTTLLDLQNNKITEIKEGDFKNLKNLHALILVNNKIK 123

  Fly   217 NMDPNAFYGLAKLKRLSLQNCGLKSLP---PQSFQGLAQLTSLQLNGNALVSLDGDCLGHLQKLR 278
            ::.|:||..|.||:||.|....||.||   |:|                              |:
Frog   124 SISPSAFASLTKLERLYLSKNNLKDLPANMPKS------------------------------LQ 158

  Fly   279 TLRLEGNLFYRIPTNALAGLRTLEALNLGSNLLTIINDEDFPRMPNLIVLLLKRNQIMKISAGAL 343
            .||:..|...::..:...||..:..:.||:|.:                      :...:..||.
Frog   159 ELRVHENSITKLKKSVFDGLNNMIVVELGTNPI----------------------ESSGVEKGAF 201

  Fly   344 KNLTALKVLELDDNLISSLPEGLSKLSQLQELSITSNRLRWINDTELPRSMQMLDMRANPLSTIS 408
            :.:..|..|.:.|..|:|:|:|                        ||.|:..|.:..|.::.:.
Frog   202 QGMKKLSYLRIADTNITSIPKG------------------------LPASLTELHLDGNKIAKVD 242

  Fly   409 PGAFRGMSKLRKLILSDVRTLRSFPELEACHALEILKLDRAGIQEVPANLCRQTPRLKSLELKTN 473
            ..:..|::.|.||.||               ...|:.|:...:..|        |.|:.|.|..|
Frog   243 SDSLNGLNNLAKLGLS---------------YNNIITLENGTVTGV--------PHLRELHLDHN 284

  Fly   474 SLKRIP-NLSSCRDLRLLDLSSNQIEKIQGKPFNGLKQLNDLL-LSYNRIKALPQDAFQGIPKLQ 536
            ||.::| .|...:.::::.|.:|:|..:         ..||.. |.||..||    ::.||
Frog   285 SLTQVPAGLGEHKYIQVVYLHNNKISAV---------STNDFCPLGYNTKKA----SYSGI---- 332

  Fly   537 LLDLEGNEISY--IHKEAFSGFTALEDLNLGN 566
              .|..|.:.|  |....|........:.:||
Frog   333 --SLFSNPVQYWEIQPATFRCVYERSAIQIGN 362

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	7/20 (35%)
		LRR_RI	180..>383	CDD:238064	46/205 (22%)
		leucine-rich repeat	183..204	CDD:275380	7/20 (35%)
		LRR_8	203..263	CDD:290566	21/62 (34%)
		leucine-rich repeat	205..228	CDD:275380	9/22 (41%)
		leucine-rich repeat	229..252	CDD:275380	10/25 (40%)
		LRR_8	252..311	CDD:290566	9/58 (16%)
		leucine-rich repeat	253..276	CDD:275380	0/22 (0%)
		leucine-rich repeat	277..300	CDD:275380	6/22 (27%)
		LRR_8	299..359	CDD:290566	8/59 (14%)
		leucine-rich repeat	301..324	CDD:275380	3/22 (14%)
		leucine-rich repeat	325..348	CDD:275380	2/22 (9%)
		LRR_RI	327..567	CDD:238064	51/244 (21%)
		leucine-rich repeat	349..371	CDD:275380	7/21 (33%)
		LRR_8	370..425	CDD:290566	10/54 (19%)
		leucine-rich repeat	372..393	CDD:275380	2/20 (10%)
		leucine-rich repeat	394..415	CDD:275380	2/20 (10%)
		leucine-rich repeat	418..486	CDD:275380	17/68 (25%)
		leucine-rich repeat	441..464	CDD:275378	3/22 (14%)
		LRR_8	487..545	CDD:290566	14/58 (24%)
		leucine-rich repeat	487..510	CDD:275380	3/22 (14%)
		leucine-rich repeat	511..534	CDD:275380	9/23 (39%)
		LRR_8	533..589	CDD:290566	7/36 (19%)
		leucine-rich repeat	535..558	CDD:275380	5/24 (21%)
		leucine-rich repeat	559..580	CDD:275380	2/8 (25%)
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
dcn	NP_001093704.1	LRRNT	58..90	CDD:214470	10/30 (33%)
		leucine-rich repeat	67..87	CDD:275380	8/21 (38%)
		PRK15370	<75..>303	CDD:185268	74/326 (23%)
		leucine-rich repeat	88..111	CDD:275380	7/22 (32%)
		leucine-rich repeat	112..135	CDD:275380	9/22 (41%)
		leucine-rich repeat	136..156	CDD:275380	9/19 (47%)
		leucine-rich repeat	157..180	CDD:275380	6/22 (27%)
		leucine-rich repeat	181..206	CDD:275380	5/46 (11%)
		leucine-rich repeat	207..227	CDD:275380	9/43 (21%)
		leucine-rich repeat	228..251	CDD:275380	3/22 (14%)
		leucine-rich repeat	252..275	CDD:275380	8/45 (18%)
		leucine-rich repeat	299..320	CDD:275380	5/29 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910