Protein Alignment NimC1 and MEGF10

DIOPT Version :10

• Sequence 1: NP_001260453.1
• Gene: NimC1 / 34816
• FlyBaseID: FBgn0259896
• Length: 622
• Species: Drosophila melanogaster
• Sequence 2: XP_016865476.1
• Gene: MEGF10 / 84466
• HGNCID: 29634
• Length: 1195
• Species: Homo sapiens
• Alignment Length: 899
• Identity: 208/899 - (23%)
• Similarity: 279/899 - (31%)
• Gaps: 348/899 - (38%)

  Fly     8 LHFVCLSLS--FGTSFAILRHGLNDCSHPESVPYNRKVLKSKLVPFQQYSY-----FHGWVTKYR 65
            |.|:||.|.  .||:..:.....|.|||.||  |:..|.:|...||.|..|     ...|....|
Human    64 LSFICLLLCHWIGTASPLNLEDPNVCSHWES--YSVTVQESYPHPFDQIYYTSCTDILNWFKCTR 126

  Fly    66 HQYVYEDETAYR----TVMR--PSCCEGYEGSVENCKPVCRQQCPQHGFCSSPNTCSCNAGYGGI 124
            |:..|  .||||    |:.|  ..||.|:..|.|.|.|.|..:| .||.|.:||||.|..|:||.
Human   127 HRVSY--RTAYRHGEKTMYRRKSQCCPGFYESGEMCVPHCADKC-VHGRCIAPNTCQCEPGWGGT 188

  Fly   125 --------------------------------------------------------DCHPVCPTV 133
                                                                    |||..|.
Human   189 NCSSACDGDHWGPHCTSRCQCKNGALCNPITGACHCAAGFRGWRCEDRCEQGTYGNDCHQRCQ-- 251

  Fly   134 CGKNEFCDR-PGVCSCQNGYKRTSPSDNCL-----PVCEKECG-------HH------------- 172
            |.....||. .|.|.|..||......|.|.     |.||:.|.       ||
Human   252 CQNGATCDHVTGECRCPPGYTGAFCEDLCPPGKHGPQCEQRCPCQNGGVCHHVTGECSCPSGWMG 316

  Fly   173 SFCSEP--------------------------GKCECEPGYEKVGNGTVFPDGYKNNSNGNCSPI 211
            :.|.:|                          |:|.|.|||                :...|...
Human   317 TVCGQPCPEGRFGKNCSQECQCHNGGTCDAATGQCHCSPGY----------------TGERCQDE 365

  Fly   212 CPKD-----CGQNSRCVR-------PGVCECENGYAGD--------DG--GTNCRPVCSTCPENG 254
            ||..     |.:..:||.       .|.|.||.|:||:        :|  |..|...|....||.
Human   366 CPVGTYGVLCAETCQCVNGGKCYHVSGACLCEAGFAGERCEARLCPEGLYGIKCDKRCPCHLENT 430

  Fly   255 LCLSP--GVCVCKPGY--VMRNDLCQP-----HCEK---CSDNAHC-VAPNQCECFPGYESSGAD 306
            ....|  |.|.||||:  :..|:.|.|     .|::   |.:.|.| ....:|.|.||::.....
Human   431 HSCHPMSGECACKPGWSGLYCNETCSPGFYGEACQQICSCQNGADCDSVTGKCTCAPGFKGIDCS 495

  Fly   307 KKCVP------KCSK--GCTNGFCFAP--ETCVCSIGYQ--------------MGPNQVCEPKCS 347
            ..| |      .||.  ||.|....:|  .:|.|..|:.              .|.|..|:
Human   496 TPC-PLGTYGINCSSRCGCKNDAVCSPVDGSCTCKAGWHGVDCSIRCPSGTWGFGCNLTCQ---- 555

  Fly   348 LNCVH-GKC-TSPETCTCDPGYRFK-------------------DNSHHE--------------- 376
              |:: |.| |...||||.||:|.:                   |.||.:
Human   556 --CLNGGACNTLDGTCTCAPGWRGEKCELPCQDGTYGLNCAERCDCSHADGCHPTTGHCRCLPGW 618

  Fly   377 ----CDPICDSG-----------CSNGHCVAPN--FCICHDGYQLNSTNPVTS------MCQPIC 418
                ||.:|..|           |.||...:|:  .|.|..|::..:...:.|      .|...|
Human   619 SGVHCDSVCAEGRWGPNCSLPCYCKNGASCSPDDGICECAPGFRGTTCQRICSPGFYGHRCSQTC 683

  Fly   419 KGC--QFGDC-VAPNVCECNVGY---------------ENINGLCELQTTTD---------SYEY 456
            ..|  ..|.| ....:|:|..|:               :|..|:|   |.|:         |.:.
Human   684 PQCVHSSGPCHHITGLCDCLPGFTGALCNEVCPSGRFGKNCAGIC---TCTNNGTCNPIDRSCQC 745

  Fly   457 STTTVELQSSTVDPQLQTSTSEVPHSNCTAGCMCWIEYDG--------MGTFNTAKCAKICVDPQ 513
            ....:....|...|......:.:...||..|..| ..|||        .|.:.|.:|.   :...
Human   746 YPGWIGSDCSQPCPPAHWGPNCIHTCNCHNGAFC-SAYDGECKCTPGWTGLYCTQRCP---LGFY 806

  Fly   514 DKPCLNLDNCQ----CDLSSGQLV---------CQEDSDMDYSGENSRYVCHILPE--------- 556
            .|.|..:..||    ||..|||..         |::.......|...|.:|..|..
Human   807 GKDCALICQCQNGADCDHISGQCTCRTGFMGRHCEQKCPSGTYGYGCRQICDCLNNSTCDHITGT 871

  Fly   557 -------QGAR-SEAEVRIPDRTGSSNKWMII-------VGSCAGMIIGVAATI 595
                   :||| .:|.|.|.....|.::....       :|:.||:||.|...:
Human   872 CYCSPGWKGARCDQAGVIIVGNLNSLSRTSTALPADSYQIGAIAGIIILVLVVL 925

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NimC1	NP_001260453.1	None
MEGF10	XP_016865476.1	EMI	86..155	CDD:462204	26/72 (36%)
		EGF_Lam	336..373	CDD:214543	9/52 (17%)
		EGF_CA	597..642	CDD:473889	7/44 (16%)