Protein Alignment NimC1 and Megf10

DIOPT Version :10

• Sequence 1: NP_001260453.1
• Gene: NimC1 / 34816
• FlyBaseID: FBgn0259896
• Length: 622
• Species: Drosophila melanogaster
• Sequence 2: NP_001001979.1
• Gene: Megf10 / 70417
• MGIID: 2685177
• Length: 1147
• Species: Mus musculus
• Alignment Length: 920
• Identity: 214/920 - (23%)
• Similarity: 291/920 - (31%)
• Gaps: 361/920 - (39%)

  Fly     8 LHFVCLSLS--FGTSFAILRHGLNDCSHPESVPYNRKVLKSKLVPFQQYSY-----FHGWVTKYR 65
            |..:|..|.  .||:.::.....|.|||.||  |:..|.:|...||.|..|     ...|....|
Mouse     9 LGLICSLLCHWVGTASSLNLEDPNVCSHWES--YSVTVQESYPHPFDQIYYTSCTDILNWFKCTR 71

  Fly    66 HQYVYEDETAYR----TVMR--PSCCEGYEGSVENCKPVCRQQCPQHGFCSSPNTCSCNAGYGGI 124
            |:..|  .||||    |:.|  ..||.|:..|.:.|.|.|..:| .||.|.:||||.|..|:||.
Mouse    72 HRISY--RTAYRHGEKTMYRRKSQCCPGFYESRDMCVPHCADKC-VHGRCIAPNTCQCEPGWGGT 133

  Fly   125 DCH---------PVCPTVCG-KNEFCDRP--GVCSCQNGYKRTSPSDNCLP-----VCEK--ECG 170
            :|.         |.|.:.|. ||.....|  |.|.|..||:.....|.|..     .|.:  :|.
Mouse   134 NCSSACDGDHWGPHCSSRCQCKNRALCNPITGACHCAAGYRGWRCEDRCEQGTYGNDCHQRCQCQ 198

  Fly   171 HHSFCSE-PGKCECEPGYE-----------KVG----------NGTV---------FPDGYKNNS 204
            :.:.|.. .|:|.|.|||.           |.|          ||.|         .|.|:....
Mouse   199 NGATCDHITGECRCSPGYTGAFCEDLCPPGKHGPHCEQRCPCQNGGVCHHVTGECSCPSGWMGTV 263

  Fly   205 NGNCSPICP-----KDCGQNSRCVRPGVCE-------CENGYAGD---------DGGTNCRPVCS 248
               |...||     |:|.|..:|...|.|:       |..||.|:         ..|..|...|
Mouse   264 ---CGQPCPEGRFGKNCSQECQCHNGGTCDAATGQCHCSPGYTGERCQDECPVGSYGVRCAEAC- 324

  Fly   249 TCPENGLCLS-PGVCVCKPGYVMRNDLCQPH----------CEK---CS-DNAHCVAP--NQCEC 296
            .|...|.|.. .|.|:|:.|:  ..:||:..          |:|   |. ||.|...|  .:|.|
Mouse   325 RCVNGGKCYHVSGTCLCEAGF--SGELCEARLCPEGLYGIKCDKRCPCHLDNTHSCHPMSGECGC 387

  Fly   297 FPGYESSGADKKCVP-----------KCSKG-----------CTNGF----CFAPETCVCSIGYQ 335
            .||:.....::.|.|           .|..|           |..||    |..|    |.:| :
Mouse   388 KPGWSGLYCNETCSPGFYGEACQQICSCQNGADCDSVTGRCACAPGFKGTDCSTP----CPLG-R 447

  Fly   336 MGPN----------QVCEP--------------KCSLNCVHG----------KC-------TSPE 359
            .|.|          .||.|              .||:.|..|          :|       |...
Mouse   448 YGINCSSRCGCKNDAVCSPVDGSCICKAGWHGVDCSIRCPSGTWGFGCNLTCQCLNGGACNTLDG 512

  Fly   360 TCTCDPGYRFK-------------------DNSHHE-CDPI--------------CDSGCSNG-- 388
            ||||.||:|..                   |.||.: |.|.              |||.|:.|
Mouse   513 TCTCAPGWRGAKCEFPCQDGTYGLNCAERCDCSHADGCHPTTGHCRCLPGWSGVHCDSVCAEGRW 577

  Fly   389 --HCVAPNFC--------------------------ICHDGYQ-----------LNSTNP---VT 411
              :|..|.:|                          ||..|:.           ::|:.|   :|
Mouse   578 GPNCSLPCYCKNGASCSPDDGICECAPGFRGTTCQRICSPGFYGHRCSQTCPQCVHSSGPCHHIT 642

  Fly   412 -----------SMCQPICKGCQFG-DCVAPNVCECNVGYENINGLCE-LQTTTDSYEYSTTTVEL 463
                       ::|..:|...:|| :|.  .||.|     ..||.|. :..:...|   ...:..
Mouse   643 GLCDCLPGFTGALCNEVCPSGRFGKNCA--GVCTC-----TNNGTCNPIDRSCQCY---PGWIGS 697

  Fly   464 QSSTVDPQLQTSTSEVPHSNCTAGCMCWIEYDG--------MGTFNTAKCAKICVDPQDKPCLNL 520
            ..|...|......:.:...||..|..| ..|||        .|.:.|.:|.   :....|.|..:
Mouse   698 DCSQPCPPAHWGPNCIHTCNCHNGAFC-SAYDGECKCTPGWTGLYCTQRCP---LGFYGKDCALI 758

  Fly   521 DNCQ----CDLSSGQLV---------CQEDSDMDYSGENSRYVCHILPE---------------- 556
            ..||    ||..|||..         |::.......|...|.:|..|..
Mouse   759 CQCQNGADCDHISGQCTCRTGFMGRHCEQKCPAGTYGYGCRQICDCLNNSTCDHITGTCYCSPGW 823

  Fly   557 QGARSEAEVRIPDRTGSSNKWMIIVGSC----------------AGMIIGVAATIIGIKY----- 600
            :|||.       |:.|     :||||:.                .|.|.|:...::.:.:
Mouse   824 KGARC-------DQAG-----VIIVGNLNSLSRTSTALPADSYQIGAIAGIVVLVLVVLFLLALF 876

  Fly   601 --YRRSTSRR 608
              ||....|:
Mouse   877 IIYRHKQKRK 886

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NimC1	NP_001260453.1	None
Megf10	NP_001001979.1	Necessary for interaction with AP2M1, self-assembly and formation of the irregular, mosaic-like adhesion pattern. /evidence=ECO:0000250|UniProtKB:Q96KG7	1..857		208/889 (23%)
		EMI	31..100	CDD:462204	26/72 (36%)
		EGF_Lam	281..318	CDD:214543	7/36 (19%)
		EGF_CA	542..587	CDD:473889	12/44 (27%)
		Necessary for formation of large intracellular vacuoles. /evidence=ECO:0000250|UniProtKB:Q96KG7	945..1147
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1093..1147