Protein Alignment NimC1 and megf6b

DIOPT Version :10

• Sequence 1: NP_001260453.1
• Gene: NimC1 / 34816
• FlyBaseID: FBgn0259896
• Length: 622
• Species: Drosophila melanogaster
• Sequence 2: XP_009304569.1
• Gene: megf6b / 557764
• ZFINID: ZDB-GENE-101112-3
• Length: 1589
• Species: Danio rerio
• Alignment Length: 626
• Identity: 166/626 - (26%)
• Similarity: 231/626 - (36%)
• Gaps: 165/626 - (26%)

  Fly    12 CLSLSFGTSFAILRH-GLNDCS----------------HPESV-------PYNRKVLKSKLVPFQ 52
            ||:::.|...|.|.. |...||                ..|||       ..|:.....:|...|
Zfish   445 CLAVNGGCDHACLNSAGSFQCSCRRGYRLDEDRRSCILMEESVEALSSGQTVNKPGPGPQLTILQ 509

  Fly    53 QYSYFHGWVTKYRHQYVYEDET----AYRTVMRPSCCEGYEGSVENCKPVCRQQCPQHGFCSS-P 112
            .:...   :.||..   |||:|    |..|:.....|......|: |...| :.|...|.|:. .
Zfish   510 DFDQI---LEKYED---YEDDTGELRAESTLAEKFICLNDSFGVD-CSLSC-EDCVNGGVCNKHR 566

  Fly   113 NTCSCNAGYGGIDCHPVCPT-VCGKNEFCDRPGVCSCQNGYKRTSPSDNCLPVCEKECGHHSFCS 176
            |.|.|..|:.|:.|:..||. ..|:|  |..  :|.|:||       ..|.||
Zfish   567 NACDCPDGWTGVVCNETCPEGWFGRN--CSL--LCKCKNG-------GVCDPV------------ 608

  Fly   177 EPGKCECEPGYEKVGNGTVFPDGYKNNSNGN-CSPICPKDCGQNSRCVRP-GVCECENGYAGD-- 237
             .|.|.|.||.    :|.:..||......|. |:..|  :|..|.||.|. |.|.|:.|..|.
Zfish   609 -SGSCRCPPGV----SGELCQDGCPKGLYGKFCNKRC--NCANNGRCHRTYGACLCDPGLYGRFC 666

  Fly   238 -------DGGTNCRPVCSTCPENGL-C-LSPGVCVCKPGYVMRNDLCQPHCEKCSDNAHCVAPNQ 293
                   ..|..|...|....:|.: | ...|.|:|||||  |...|:..||.....:.|  .|:
Zfish   667 HLPCPKWMFGPGCSEECQCVQQNTIECHRHHGDCICKPGY--RGHTCKDECESGFFGSAC--ENK 727

  Fly   294 CECFPGYESSGADKKCVPKCSKGCTNGFCFAPETCVCSIGYQMGPNQVCEPKCS---LNCVHGKC 355
            |.|.||.........|.|||..|.|...|  .:.|| ...:.:|.:|.|:  ||   .:.|.|:|
Zfish   728 CSCPPGVTCDHVTGACQPKCPAGKTGDKC--DQDCV-EGRFGIGCSQSCD--CSGAPCDKVTGQC 787

  Fly   356 TSP-----ETC--TCDPGYRFKDNSHHECDPICDSG--CS--NGHCV-APNF------------- 395
            |.|     :.|  .|..| |:.......| |:|::|  |.  ||.|| :|.|
Zfish   788 TCPAGTFGKRCEKECPEG-RWGLGCQEWC-PVCENGGRCDRRNGTCVCSPGFIGRLCQNSCPAGR 850

  Fly   396 --------CICHDGYQLNSTNPVTSM-----------CQPICKGCQFG-DCVAPNVCECNVGYEN 440
                    |:|..|.:   .|||:..           |:.:|...::| ||  .:||:|    .|
Zfish   851 FGVGCQLRCVCDLGVR---CNPVSGRCSCPPGWTGHNCRKVCDAGRWGLDC--ESVCDC----RN 906

  Fly   441 INGLCELQTTTDSYEYSTTTV----ELQSSTVDPQLQTSTSEVPHSNCT-AGCMCWIEYDGMGTF 500
            .:|:|:.||.....|...|..    :..:.:..|..:........::|. .|..|..:....|||
Zfish   907 ADGVCDAQTGRCHCEAGFTGARCDQKCPAGSFGPGCKHRCQCENQASCDHVGGACTCKTGWTGTF 971

  Fly   501 NTAKCAKIC------VDPQDKPCLNLDNCQCDLSSGQLVCQ 535
                |.|.|      :|.|.| |:.|:...||..|||..|:
Zfish   972 ----CEKPCPQGFYGLDCQQK-CVCLNGGLCDHVSGQCFCK 1007

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NimC1	NP_001260453.1	None
megf6b	XP_009304569.1	EMI	32..103	CDD:462204
		FXa_inhibition	152..187	CDD:464251
		FXa_inhibition	193..228	CDD:464251
		FXa_inhibition	234..270	CDD:464251
		FXa_inhibition	276..311	CDD:464251
		vWFA	<308..350	CDD:469594
		FXa_inhibition	363..398	CDD:464251
		vWFA	<396..436	CDD:469594
		FXa_inhibition	445..480	CDD:464251	8/34 (24%)