Protein Alignment Smg5 and Smg5

DIOPT Version :10

• Sequence 1: NP_609685.1
• Gene: Smg5 / 34804
• FlyBaseID: FBgn0019890
• Length: 1177
• Species: Drosophila melanogaster
• Sequence 2: XP_038959679.1
• Gene: Smg5 / 681012
• RGDID: 1584731
• Length: 1018
• Species: Rattus norvegicus
• Alignment Length: 1281
• Identity: 275/1281 - (21%)
• Similarity: 455/1281 - (35%)
• Gaps: 419/1281 - (32%)

  Fly    37 ILSQEVKD------LYRSLYTASKQLDDAKRNVQSVGQLFQHEIEEKRSLLVQLCKQIIFKDYQS 95
            :..:|::|      |..::..|..:||....|..:..::|:.|....|:.|.:||.:::|.....
  Rat    10 VKKEELRDSCSLPLLTLAVVEAVHRLDLILCNKTAYQEVFKPENVSLRNKLRELCVKLMFLHPVD 74

  Fly    96 VGKKVREVMWRRGYYEFIAFVKKNWHKQCQDAATAQENMQKLERFLCAGIFNYKRLSARMEEIYD 160
            .|:|..|::||:.|||.|..:|.| .|.....:|.:   ......|.|||..|:.|...::..|.
  Rat    75 YGRKAEELLWRKVYYEVIQLIKTN-KKHIHSRSTLE---CAYRTHLVAGIGFYQHLLLYIQSHYQ 135

  Fly   161 LDLKYLIDFSIISDGYISDMIGDTMESSHSGTHAVDKSLEAVSFALDTIHSSLLSLGDLHRYFLD 225
            |:|:..||::.::|    .:||.....|.||        :.:.:|....|..|:.||||.||..:
  Rat   136 LELQCCIDWTHVTD----PLIGCKKPVSASG--------KEMDWAQMACHRCLVYLGDLSRYQNE 188

  Fly   226 FR-IDSKLSISKEQVAKYYLEAFKLNPAIGMAQNQLGTLHYGQNHDLDSTYHYLYSLVCIIPFEL 289
            .. :|::|     ...::|.:|..:.|.|||..||||||...:.:.:::.|.||..:...:.||.
  Rat   189 LAGVDTEL-----LAERFYYQALSVAPQIGMPFNQLGTLAGSKYYSVEAMYCYLRCIQSEVSFEG 248

  Fly   290 SENNLNKLF---AKHTEYLERMDPEKLD------FNIEDFFARFYLIVDIF-----FFDKEVPDF 340
            :..||.:|:   ||....|::.:..||.      .:|:.....|..:..:.     ..|.|:
  Rat   249 AYGNLKRLYDKAAKMYHQLKKSETRKLSPSKKRCKDIKRLLVNFMYLQSLLQPKSSSVDSEL--- 310

  Fly   341 NALCHCVLIDLRKILC---------------------SQQLRVPEPSIFKIVSILFFCLSKLKMI 384
            .:||..||.|..  ||                     |....:|:..||::..|....:..||..
  Rat   311 TSLCQSVLEDFN--LCLFYLPSSPSLGLTNEDEEECESGYAFLPDLLIFQMAIICLMGVHSLKRA 373

  Fly   385 NSPKVYSLHAFLVAACSDLMDACIVSIEQTILARAQDNERFQAEYEERFQEFDTVVRKSRNEYKN 449
            .|.:..:..||.:|..|.|::              ..|.|.|||.||
  Rat   374 GSKQYSAAIAFTLALFSHLIN--------------HVNIRLQAELEE------------------ 406

  Fly   450 WLAAVGECERKDKKLMPRPHSLKDCSSDSRDSQHSGEEAKTQEAADGDKIGEAVSTRSSDEAKES 514
                 ||            :.:....||..|...| :||..:|..:.:   .......:||.::|
  Rat   407 -----GE------------NPVSAFQSDGTDEPES-KEALEKEEPEPE---PPTVVPQADEGRKS 450

  Fly   515 DLKTPLSCKSKRRGMRLRRRRRKIAQSDDSSCYDSESELDTDFYSDEEDYTDLSSNFDTDFSDID 579
            ...:.|||      :|.|||.......|||                     |||..|::| |..|
  Rat   451 RKHSRLSC------LRRRRRHHPPKAGDDS---------------------DLSEGFESD-SSHD 487

  Fly   580 AADPGEPCGEERYAAANYSKKERKAGGGGGGGVGGVVYSDNEDVVIEEEKIVYPNEVERRSNSQE 644
            :|                     :|..|...|         .|..:|.....:..|.:...||||
  Rat   488 SA---------------------QASDGSDSG---------SDKSLEGRGTAFDAETDSEMNSQE 522

  Fly   645 ADSEELLRSFEVLQLNFKSAEDAQSKPVAPPPVSFSEPPKKL---------------------VY 688
            :.|:  |...|        .|:....|...||.:.||.|..|                     ::
  Rat   523 SRSD--LEDIE--------DEEGTRSPAQEPPQTRSEVPDSLNGPLGPSEASIASNLQAMSTQMF 577

  Fly   689 RNK--------YTKI------NPNIV--------------------------------------- 700
            :.|        ::.:      .||.|
  Rat   578 QTKRCFRLAPTFSNLLLQPTAEPNSVASHRPCVNGDMEKPLEPASEDGSESEGSESSSRSCRNER 642

  Fly   701 -----IDCLHNEPTIRALKMLFDWLRINPEILIGCYHSNPEFVHKIMKLLNYCNIDIFTRKVYFE 760
                 :..|..|..:.|:|:..||||.||:::|.|..|:....:::..|||.
  Rat   643 SLQEKLQALMAEGLLPAVKVFLDWLRTNPDLIIVCAQSSQSLWNRLSVLLNL------------- 694

  Fly   761 RDLLTTANVRDSLV-------------ELFDVRANVPLTEDFAFKNFDIFQSTQITLDWETIIRE 812
              |..:..::||.:             ||.|:.|::.|.||.|.:|....::.....:::. .|.
  Rat   695 --LPASGELQDSGLALCSEVQGLLEGCELPDLPASLLLPEDMALRNLPPLRAAHRRFNFDA-DRP 756

  Fly   813 RVTPQEESILRIFKMVDFGFFICKQKKFNYRFCVKTRRFTETQKKKQREEKKGGGSRRRERRTAP 877
            .::..|||::||..:..||.|:.:
  Rat   757 LLSALEESVVRICYIRSFGHFVAR----------------------------------------- 780

  Fly   878 KTNRTKRNEGRTRRYSDRKNGIVRKSYTSNEEKDTVEECRKMPRKGYLRNRNAEKAAAVITSATG 942
                                                       .:|.:...|.|....|
  Rat   781 -------------------------------------------LQGSILQFNPEVGIFV------ 796

  Fly   943 TSVAGGTSASTTTNSVIEKLNLQSSSGADEERSEAKSKKCELMGKLWLQNEVETLEEELRDSPAH 1007
                  :.|.:...|::::...|.....:|.|   :::....|.:|.||.||..||..|:...|.
  Rat   797 ------SIAQSEQESLLQQAQAQFRMAEEEAR---RNRLMRDMAQLRLQLEVSQLEGSLQQPKAQ 852

  Fly  1008 VVMSPFVVVDSKALTEYNGIVKSLVRTKKCIVLIPNAVLNELDDLKKRSENVRHVIRWLEQEFKQ 1072
            ..|||:::.|::||..:..:::.|..:.:.|::||..|::.||.|||.....|..||:||.|||:
  Rat   853 SAMSPYLIPDTQALCYHLPVIRQLATSGRFIIIIPRTVIDGLDLLKKEQPGARDGIRYLEAEFKK 917

  Fly  1073 GNRHLRAQRD-NESQPLSLLKISRKMDRDASVFLQIAQFCNHLV----ANHADPHVSELQKSVVT 1132
            |||::|.|:: .:|.....||   :.|.||....:|...|..|.    |...||      ..:||
  Rat   918 GNRYIRCQKEVGKSFERHKLK---RQDADAWTLYKILDSCRQLTLAQGAGEEDP------SGMVT 973

  Fly  1133 YLSGDNLHEKNRQQQNFSYTGILD-----SIPVRYAQIQSFYAKFK 1173
            .::|  ||..|....:......|.     |:.|:  .:..||.::|
  Rat   974 IITG--LHLDNPSALSGPMQAALQAAAHASVDVK--NVLDFYRQWK 1015

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Smg5	NP_609685.1	EST1	99..227	CDD:463062	38/127 (30%)
		EST1_DNA_bind	240..479	CDD:431239	60/273 (22%)
		MSCRAMM_ClfA	<470..>580	CDD:468110	26/109 (24%)
		PIN_Smg5-like	1012..1173	CDD:350232	50/170 (29%)
Smg5	XP_038959679.1	EST1	78..189	CDD:463062	30/110 (27%)
		EST1_DNA_bind	198..>412	CDD:431239	58/249 (23%)
		EST1_DNA_bind	<653..746	CDD:431239	26/171 (15%)
		PIN_Smg5-like	857..1015	CDD:350232	27/157 (17%)