DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tehao and TLR1

DIOPT Version :10

Sequence 1:NP_477438.1 Gene:Tehao / 34761 FlyBaseID:FBgn0026760 Length:795 Species:Drosophila melanogaster
Sequence 2:NP_003254.2 Gene:TLR1 / 7096 HGNCID:11847 Length:786 Species:Homo sapiens


Alignment Length:823 Identity:192/823 - (23%)
Similarity:327/823 - (39%) Gaps:201/823 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    45 NVVRFHCPDEYAMLLEVSEPGASLYMSYYASTELQWLPRFNISSLVKIEFDAYIFWP--EKF--L 105
            :|.:|:...||            |.:|:....::...|..|:..| .:.|:|:...|  ::|  :
Human    87 SVFKFNQELEY------------LDLSHNKLVKISCHPTVNLKHL-DLSFNAFDALPICKEFGNM 138

  Fly   106 SDLLKTLGVQTVKTIIFRDRTLETV---VTRDVLNSGNGYMETSQPENITTWHFGSVPGLKKFKF 167
            |. ||.||:.|  |.:.:...|...   :::.:|..|..|.|...||           ||:.|. 
Human   139 SQ-LKFLGLST--THLEKSSVLPIAHLNISKVLLVLGETYGEKEDPE-----------GLQDFN- 188

  Fly   168 FSHVPELQESIFHGFDTLRDLH--LSVNVTTLPGNMLSTVNGTLKTLTIESPGIVSFGNPLLREL 230
                   .||:...|.|.::.|  |.|:|.|:....||.:...|:      ....|:...:|.:|
Human   189 -------TESLHIVFPTNKEFHFILDVSVKTVANLELSNIKCVLE------DNKCSYFLSILAKL 240

  Fly   231 Q---QLRNLSLALIHPFHE---RDKQLQPH---FFGSMTNLE-EVRLASATSSVNRSMFKGTNKL 285
            |   :|.||:|..|.....   |..||..|   ::.|::|:: :.:|.......:.:..|..:..
Human   241 QTNPKLSNLTLNNIETTWNSFIRILQLVWHTTVWYFSISNVKLQGQLDFRDFDYSGTSLKALSIH 305

  Fly   286 QLIKMNGNDDLMELPG----EIFLDQVNLKTLDLS--------CNAIVT--LHED---------V 327
            |::     .|:...|.    ||| ..:|:|...:|        |.:.::  ||.|         |
Human   306 QVV-----SDVFGFPQSYIYEIF-SNMNIKNFTVSGTRMVHMLCPSKISPFLHLDFSNNLLTDTV 364

  Fly   328 FKGLGNLTLLD---LSKNRLTNLS--STIFAPLTSLNVLRLNKNSLTAMSPSVFQDVVSLNYIEM 387
            |:..|:||.|:   |..|:|..||  :.:...:.||..|.:::|              |::|.|.
Human   365 FENCGHLTELETLILQMNQLKELSKIAEMTTQMKSLQQLDISQN--------------SVSYDEK 415

  Fly   388 VNTQFYGATLL-MNYEAVVCTNDEACQYKSAEWQCDPRCICWVQRSVGSLIVDCRGTSLEELPDL 451
            .....:..:|| :|..:.:.|:        ..::|.|..|         .::|.....::.:|  
Human   416 KGDCSWTKSLLSLNMSSNILTD--------TIFRCLPPRI---------KVLDLHSNKIKSIP-- 461

  Fly   452 PRTTLLSTV--LKVGNNSLTSLPTVSEHSGYANVSGLFLSDNNLTSLGSGDQLPDNLTHLDVRGN 514
            .:...|..:  |.|..||||.||.....|..:    :.:.|:|..|..|.|              
Human   462 KQVVKLEALQELNVAFNSLTDLPGCGSFSSLS----VLIIDHNSVSHPSAD-------------- 508

  Fly   515 QIQSLSDEFLLFLQEPNNTMTLSLSGNPITCGCESLSLLFFVRTNPQRVRDIAD-----IVCTKQ 574
                       |.|......::....||..|.||   |..||:...|...::.:     ..|...
Human   509 -----------FFQSCQKMRSIKAGDNPFQCTCE---LGEFVKNIDQVSSEVLEGWPDSYKCDYP 559

  Fly   575 K-------KSFQQMEAFELCPSYVLLISCVVGGLVIVICLLTVFYLMFQQELKIWLYNNNLCLWW 632
            :       |.|...|.  .|...:|:::.|...||:.:   ||..|....:|. | |...:|.|.
Human   560 ESYRGTLLKDFHMSEL--SCNITLLIVTIVATMLVLAV---TVTSLCSYLDLP-W-YLRMVCQWT 617

  Fly   633 --------VSEEELDKDKTYDAFISYSHKDEELI-SKLLPKLESGPHPFRLCLHDRDWLVGDCIP 688
                    :..|||.::..:.||||||..|...: ::|||.||.  ...::|||:|:::.|..|.
Human   618 QTRRRARNIPLEELQRNLQFHAFISYSGHDSFWVKNELLPNLEK--EGMQICLHERNFVPGKSIV 680

  Fly   689 EQIVRTVDDSKRVIIVLSQHFIDSVWARMEFRIAYQATLQDKRKRIIIILYRELEHMNGIDS--E 751
            |.|:..::.|.:.|.|||.:|:.|.|...|...|:.....:....:|:||...:...:...|  :
Human   681 ENIITCIEKSYKSIFVLSPNFVQSEWCHYELYFAHHNLFHEGSNSLILILLEPIPQYSIPSSYHK 745

  Fly   752 LRAYLKLNTYLKWGDP-----LFWSKLYYAMPHNRRVLKGQKK 789
            |::.:...|||:|...     |||:.|..|:  |.::.:..||
Human   746 LKSLMARRTYLEWPKEKSKRGLFWANLRAAI--NIKLTEQAKK 786

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TehaoNP_477438.1 LRR 184..>541 CDD:443914 83/399 (21%)
leucine-rich repeat 185..207 CDD:275380 7/23 (30%)
leucine-rich repeat 209..232 CDD:275380 5/25 (20%)
leucine-rich repeat 233..261 CDD:275380 10/33 (30%)
leucine-rich repeat 262..284 CDD:275380 2/22 (9%)
leucine-rich repeat 285..309 CDD:275380 6/27 (22%)
leucine-rich repeat 310..333 CDD:275380 8/41 (20%)
leucine-rich repeat 334..357 CDD:275380 8/27 (30%)
leucine-rich repeat 358..381 CDD:275380 3/22 (14%)
leucine-rich repeat 445..482 CDD:275380 11/38 (29%)
leucine-rich repeat 483..505 CDD:275380 5/21 (24%)
TIR 643..779 CDD:214587 44/143 (31%)
TLR1NP_003254.2 LRR <29..>152 CDD:443914 20/80 (25%)
leucine-rich repeat 47..70 CDD:275378
LRR 1 54..77
leucine-rich repeat 71..94 CDD:275378 2/6 (33%)
LRR 2 78..101 5/25 (20%)
leucine-rich repeat 95..115 CDD:275378 5/31 (16%)
LRR 3 102..125 4/23 (17%)
leucine-rich repeat 116..140 CDD:275378 5/24 (21%)
LRR 4 126..150 8/26 (31%)
leucine-rich repeat 141..152 CDD:275378 6/12 (50%)
LRR 5 151..175 3/23 (13%)
LRR 6 176..199 9/41 (22%)
LRR 7 200..223 7/22 (32%)
LRR 215..>526 CDD:443914 78/384 (20%)
LRR 8 224..250 7/31 (23%)
LRR 9 251..278 6/26 (23%)
LRR 10 279..308 4/28 (14%)
LRR 11 309..337 8/28 (29%)
Interaction with bacterial lipopeptide 313..316 0/2 (0%)
LRR 12 338..361 4/22 (18%)
leucine-rich repeat 352..373 CDD:275380 6/20 (30%)
LRR 13 362..388 9/25 (36%)
leucine-rich repeat 374..399 CDD:275380 6/24 (25%)
LRR 14 389..414 6/38 (16%)
leucine-rich repeat 400..424 CDD:275380 6/37 (16%)
LRR 15 415..437 3/21 (14%)
leucine-rich repeat 425..446 CDD:275380 6/28 (21%)
LRR 16 438..457 4/27 (15%)
leucine-rich repeat 447..469 CDD:275380 4/32 (13%)
LRR 17 458..478 4/21 (19%)
leucine-rich repeat 470..492 CDD:275380 9/21 (43%)
LRR 18 479..500 7/24 (29%)
leucine-rich repeat 494..515 CDD:275380 7/45 (16%)
LRR 19 501..524 5/47 (11%)
LRRCT 524..577 CDD:214507 13/57 (23%)
TIR 636..779 CDD:214587 45/146 (31%)
Blue background indicates that the domain is not in the aligned region.

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