DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10859 and dync2i2

DIOPT Version :9

Sequence 1:	NP_001285898.1	Gene:	CG10859 / 34756	FlyBaseID:	FBgn0032520	Length:	627	Species:	Drosophila melanogaster
Sequence 2:	NP_001099160.1	Gene:	dync2i2 / 794361	ZFINID:	ZDB-GENE-070928-9	Length:	501	Species:	Danio rerio

Alignment Length:	349	Identity:	80/349 - (22%)
Similarity:	121/349 - (34%)	Gaps:	71/349 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   218 WNLD----DATRPAAHYDSRRVVRVAKVCL----RDESYMVGGLQEGQVGFWLTEN-------QG 267
            ||:|    :..||....|    |....:||    ...|.:.|||..|:|..|.|..       |.
Zfish   163 WNVDRQNLNPKRPDVIID----VATPVMCLCFHPVRPSVVAGGLYSGEVVVWDTSRSQDLILAQT 223

  Fly   268 GPKSMCPLEACHREATTAICWVHSKLNTEF--YSGSLDGSIKYW-----DTRDLLMPVHEVLAEP 325
            |..:     ..|||....|.||......||  .|....|.:..|     :.:.||...:.::.:.
Zfish   224 GMSA-----DTHREPVYQINWVPGARRGEFSVLSAGSGGRVLLWTIDGSEAKLLLSSGYALVRQQ 283

  Fly   326 DPQTVQNRQDAHGVTFLEFEYTIPVRFIFCT--DMGYLFVGNRKG-------------TTPQD-- 373
            .||       :...:......||.|..:..:  |:....||:..|             ..|.|
Zfish   284 MPQ-------SGAASKTRGSLTIGVTAVALSPWDLDTFLVGSEGGLVLKCSFSSETAAAVPSDGE 341

  Fly   374 -TIVAAYQLFA-----GPIRCVMRNPFFVKNFLVVGDWRVRIWSEEVKNCPSTFYFRRPNQLLSG 432
             .|:.|...|:     |||..|..:||....|:.||...:......::.||........:.:...
Zfish   342 SVILRAPMQFSFSPRGGPIHSVHFSPFHRNLFVSVGTDGLAHLHSVLQPCPLLALRVSDSYVFGV 406

  Fly   433 AWSTGRCSLFCIGDNMGNLEFWDLLMSHKRPILTIKYK------YAVTHLVFKPDGT-MLTVSLA 490
            .||..|..:|......|.::.:||.....||:.||...      |.   |.|.|..| :|.|..|
Zfish   407 RWSPTRPLVFAAVTGQGLVQMFDLGRRSLRPVATIDQNAGGQPAYC---LEFNPKHTNLLAVGNA 468

  Fly   491 NGDCLMLRLEEGMRSATNKEKSLM 514
            :|...:.:|...:.....||.:::
Zfish   469 DGSVNIWQLSAELTEQGAKETAML 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10859	NP_001285898.1	WD40	<245..310	CDD:295369	21/78 (27%)
		WD40	261..>512	CDD:225201	65/294 (22%)
		WD40	279..492	CDD:295369	57/249 (23%)
		WD40 repeat	284..332	CDD:293791	12/54 (22%)
		WD40 repeat	386..422	CDD:293791	9/35 (26%)
		WD40 repeat	429..454	CDD:293791	5/24 (21%)
dync2i2	NP_001099160.1	WD40	66..481	CDD:225201	78/336 (23%)
		WD40 repeat	130..180	CDD:293791	5/16 (31%)
		WD40 repeat	187..229	CDD:293791	12/46 (26%)
		WD40 repeat	235..296	CDD:293791	12/67 (18%)
		WD40 repeat	301..338	CDD:293791	5/36 (14%)
		WD40 repeat	361..399	CDD:293791	8/37 (22%)
		WD40 repeat	403..442	CDD:293791	10/38 (26%)
		WD40 repeat	450..477	CDD:293791	9/29 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1587
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810