DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10859 and dync1i1

DIOPT Version :9

Sequence 1:	NP_001285898.1	Gene:	CG10859 / 34756	FlyBaseID:	FBgn0032520	Length:	627	Species:	Drosophila melanogaster
Sequence 2:	XP_009290517.1	Gene:	dync1i1 / 561525	ZFINID:	ZDB-GENE-061215-62	Length:	647	Species:	Danio rerio

Alignment Length:	403	Identity:	76/403 - (18%)
Similarity:	146/403 - (36%)	Gaps:	77/403 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 MDEESTMRYRKKVERDDSWGIEVNQLMHAAMDISSANNAVNIYE-------DFFVDL-------- 140
            ::||.|... ::|...:....|..|::|:...:...:.::.:.|       |.|.|.
Zfish   201 LEEEKTQEV-EEVHPRELTNEEKEQIVHSEDFLFFFDRSIRVVERVLAEDKDIFFDYSGRDMEDK 264

  Fly   141 PEDLGRGISMKIAARGTHVFHDLWIPSRRLMTCEWLNNDPNQFLLFYSNRMSLTPDYTKQLNTLP 205
            ..||..|.::..   ..|.:.:.|...|.:.:.:|                  :|.|.:.|....
Zfish   265 EGDLQAGSNLSF---NRHFYDEHWSKHRVVTSLDW------------------SPQYPELLVASY 308

  Fly   206 DFGNDNPH----AFYIWNL--DDATRPAAHYDSRRVVRVAKVCLRDESYMVGGLQEGQVGFWLTE 264
            :...|.||    ...:||:  ..|| |...:..:..|..........:.::||...||:..|  :
Zfish   309 NTNEDAPHEPDGVVLVWNMKFKKAT-PEYIFHCQSSVMSVGFAQFHPNLVIGGTYSGQIAMW--D 370

  Fly   265 NQG---GPKSMCPLEA-CHREATTAICWVHSKLNTEFYSGSLDGSIKYWDTRDLLMPVHEVLAEP 325
            |:.   .|....||.| .|......:..|.::......:.|.||.:..|..        ::|::|
Zfish   371 NRSHRRTPVQRTPLSATAHTHPVYCVNVVGTQNANNLITVSTDGKMCSWSL--------DMLSQP 427

  Fly   326 DP--QTVQNRQDAHGVTFLEFEYTIPVRFIFCTDMGYLFVGNRKGTTPQDTIVAAYQLFAGPIRC 388
            ..  :.:.|:.....||.:.|..:....::..::.|.::..:|.|:  :..|...:....||:..
Zfish   428 QESMELIYNKSKPVAVTCMAFPASDVNNYVVGSEEGTVYTASRHGS--KAGIGEIFDGHQGPVTG 490

  Fly   389 V----------MRNPFFVKNFLVVGDWRVRIWSEEVKNCPSTFYFRRPNQLLSGAWSTGRCSLFC 443
            :          ..:.|...:|    ||.|::||.: .|.|...:....:.:....||....:||.
Zfish   491 ISCHNAVGPVDFSHLFTTSSF----DWTVKLWSTK-HNKPLYSFEDNADYVYDVMWSPVHPALFA 550

  Fly   444 IGDNMGNLEFWDL 456
            ..|..|.|:.|:|
Zfish   551 TVDGNGRLDLWNL 563

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10859	NP_001285898.1	WD40	<245..310	CDD:295369	15/68 (22%)
		WD40	261..>512	CDD:225201	42/212 (20%)
		WD40	279..492	CDD:295369	36/190 (19%)
		WD40 repeat	284..332	CDD:293791	7/49 (14%)
		WD40 repeat	386..422	CDD:293791	9/45 (20%)
		WD40 repeat	429..454	CDD:293791	7/24 (29%)
dync1i1	XP_009290517.1	Dynein_IC2	147..175	CDD:288403
		WD40	215..608	CDD:225201	72/388 (19%)
		WD40	284..607	CDD:295369	61/316 (19%)
		WD40 repeat	292..337	CDD:293791	12/63 (19%)
		WD40 repeat	347..388	CDD:293791	10/42 (24%)
		WD40 repeat	394..437	CDD:293791	7/50 (14%)
		WD40 repeat	443..490	CDD:293791	9/48 (19%)
		WD40 repeat	498..530	CDD:293791	9/36 (25%)
		WD40 repeat	536..574	CDD:293791	9/28 (32%)
		WD40 repeat	582..608	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1587
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810