Protein Alignment Sirt1 and sirt1

DIOPT Version :10

• Sequence 1: NP_477351.1
• Gene: Sirt1 / 34708
• FlyBaseID: FBgn0024291
• Length: 823
• Species: Drosophila melanogaster
• Sequence 2: XP_001334440.5
• Gene: sirt1 / 797132
• ZFINID: ZDB-GENE-070801-2
• Length: 742
• Species: Danio rerio
• Alignment Length: 760
• Identity: 296/760 - (38%)
• Similarity: 405/760 - (53%)
• Gaps: 141/760 - (18%)

  Fly    41 LASTSTEAEAEAEATATTTE--PATSELAGKANGEIKTKTLAAREEQEIGANLEHKTKNPTKSMG 103
            |...|.::|..|.|.|.|.:  ||..:                ..:|.:..|..:.|: ||:. |
Zfish    24 LLELSGDSEHSATAGADTLDEKPARMD----------------ESQQALSINNNNNTR-PTEP-G 70

  Fly   104 EDEDDEEEEEEDDEEEEEDDEEGITGTS--NEDEDSSSNCSSSVEPDW-------KLRWLQREFY 159
            :..|.|.|..|..:|....:  |.|...  .:|:|.||..|||   ||       ..|::|:...
Zfish    71 QPADPEPEISELTDEGVHSN--GFTSPDLLRDDDDCSSRASSS---DWTPQPQIGSYRFIQQHIM 130

  Fly   160 TGRVPRQVIASIMPHFATGLAGDTDDSVLWDYLAHLLNEPKRRNKLASVNTFDDVISLVKKSQKI 224
            .|..||.::..::|.  |.|..|.||..||..:.: ::||.:|.|...:||.:||:.|:.:.:||
Zfish   131 RGTDPRAILKDLLPE--TVLPPDLDDMTLWQIIIN-ISEPPKRKKRKDINTLEDVVRLLNERKKI 192

  Fly   225 IVLTGAGVSVSCGIPDFRSTNGIYARLAHDFPDLPDPQAMFDINYFKRDPRPFYKFAREIYPGEF 289
            :||||||||||||||||||.:|||||||.||||||||||||||:||:||||||:|||:|||||:|
Zfish   193 LVLTGAGVSVSCGIPDFRSRDGIYARLAVDFPDLPDPQAMFDIDYFRRDPRPFFKFAKEIYPGQF 257

  Fly   290 QPSPCHRFIKMLETKGKLLRNYTQNIDTLERVAGIQRVIECHGSFSTASCTKCRFKCNADALRAD 354
            |||||||||.||:.||:|||||||||||||:|||||::|:|||||:||||..|:.|.:.:|:|.|
Zfish   258 QPSPCHRFISMLDKKGRLLRNYTQNIDTLEQVAGIQKIIQCHGSFATASCLICKHKVDCEAIRED 322

  Fly   355 IFAQRIPVCPQCQPNKEQSVDASVAVTEEELRQLVENGIMKPDIVFFGEGLPDEYHTVMATDKDV 419
            ||.|.:|.||:|..:                   |...|||||||||||.||:.:|..|..|||.
Zfish   323 IFNQVVPHCPRCPSD-------------------VPYAIMKPDIVFFGENLPEFFHRAMKQDKDE 368

  Fly   420 CDLLIVIGSSLKVRPVAHIPSSIPATVPQILINREQLHHLKFDVELLGDSDVIINQICHRLSDND 484
            .||||||||||||||||.||||||..|||:|||||.|.||.||||||||.|||:|::||||  |.
Zfish   369 VDLLIVIGSSLKVRPVALIPSSIPHDVPQVLINREPLPHLNFDVELLGDCDVIVNELCHRL--NG 431

  Fly   485 DCWRQLCCDESVLTE-SKELMPPEHSNH----HLHHHLLH----------------------HRH 522
            | ::|||.:.|.|:| :::...|||:.:    |.|....|                      |.|
Zfish   432 D-FQQLCYNSSRLSEITEKPAAPEHTENTSADHSHADAEHIENTSADRDDADAEHIENTSADHSH 495

  Fly   523 CSSESERQSQLDTD---------TQSIKSNSSADYILGSAGTCSDSGFESSTFSCGKRSTAAE-- 576
            ..:|....:..|.|         |.:..|::.|::|..::....|:....:|.:....:...|
Zfish   496 ADAEHIENTSADRDDADAEHIENTSADHSHADAEHIENTSADRDDAEHTENTPTDHANAEHTEHT 560

  Fly   577 ------AAAIERIKTDILVELNETTALSCDRLGLEGPQTTVESYRHLSIDSSKDSGIEQCDNEAT 635
                  |..||.:.||.....::.::||.:...|..|  ..|::   ::||::.|...:...||.
Zfish   561 SAGHVNAEHIEHMSTDHANAKDDQSSLSVNEEELASP--AAETH---ALDSTEISAHTERSKEAD 620

  Fly   636 PSYVRPSNLVQE---TKTVAPSL-----------TPIPQQRGKRQTAAERLQPGTFYSHTNNYSY 686
            ......:..|::   |..:...:           :||.::.|..|           |.......|
Zfish   621 AVNTDDAACVKDEENTDRLRVEMRRRCWRSRICQSPISKRLGASQ-----------YLFQAPNRY 674

  Fly   687 VFPGAQVFWDNDYSDDDDEEEERSHNRHSDLFGNVGHNYKDDDED 731
            ||.||:|     ||..:||... |.:..||  |:..|...:.:|:
Zfish   675 VFHGAEV-----YSSSEDESSS-SCSSESD--GSFQHEDSEVEEN 711

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sirt1	NP_477351.1	SIRT1	222..476	CDD:238699	175/253 (69%)
sirt1	XP_001334440.5	None