Protein Alignment Sirt1 and Sirt3

DIOPT Version :10

• Sequence 1: NP_477351.1
• Gene: Sirt1 / 34708
• FlyBaseID: FBgn0024291
• Length: 823
• Species: Drosophila melanogaster
• Sequence 2: NP_001171275.1
• Gene: Sirt3 / 64384
• MGIID: 1927665
• Length: 334
• Species: Mus musculus
• Alignment Length: 269
• Identity: 105/269 - (39%)
• Similarity: 160/269 - (59%)
• Gaps: 37/269 - (13%)

  Fly   210 TFDDVISLV--KKSQKIIVLTGAGVSVSCGIPDFRST-NGIYARLAHDFPDLPDPQAMFDINYFK 271
            :..||..|:  :...:::|:.|||:|...|||||||. :|:|:.|..  .|:|.|:|:|::.:|.
Mouse    59 SLQDVAELLRTRACSRVVVMVGAGISTPSGIPDFRSPGSGLYSNLQQ--YDIPYPEAIFELGFFF 121

  Fly   272 RDPRPFYKFAREIYPGEFQPSPCHRFIKMLETKGKLLRNYTQNIDTLERVAGI--QRVIECHGSF 334
            .:|:||:..|:|:|||.::|:..|.|:::|..|..|||.||||||.|||.:||  .:::|.||:|
Mouse   122 HNPKPFFMLAKELYPGHYRPNVTHYFLRLLHDKELLLRLYTQNIDGLERASGIPASKLVEAHGTF 186

  Fly   335 STASCTKCRFKCNADALRADIFAQRIPVCPQCQPNKEQSVDASVAVTEEELRQLVENGIMKPDIV 399
            .||:||.||.....:.:.||:.|.|:|.||.|                        .|::|||||
Mouse   187 VTATCTVCRRSFPGEDIWADVMADRVPRCPVC------------------------TGVVKPDIV 227

  Fly   400 FFGEGLPDEYHTVMATDKDVCDLLIVIGSSLKVRPVAHIPSSIPATVPQILINRE-----QLHHL 459
            ||||.||..:...|| |..:.|||:::|:||:|.|.|.:..::..:||::||||:     .|...
Mouse   228 FFGEQLPARFLLHMA-DFALADLLLILGTSLEVEPFASLSEAVQKSVPRLLINRDLVGPFVLSPR 291

  Fly   460 KFDVELLGD 468
            :.||..|||
Mouse   292 RKDVVQLGD 300

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sirt1	NP_477351.1	SIRT1	222..476	CDD:238699	102/255 (40%)
Sirt3	NP_001171275.1	SIRT1	74..308	CDD:238699	102/254 (40%)