Protein Alignment Sirt1 and sirt3

DIOPT Version :10

• Sequence 1: NP_477351.1
• Gene: Sirt1 / 34708
• FlyBaseID: FBgn0024291
• Length: 823
• Species: Drosophila melanogaster
• Sequence 2: XP_009301762.1
• Gene: sirt3 / 558775
• ZFINID: ZDB-GENE-070112-1762
• Length: 358
• Species: Danio rerio
• Alignment Length: 281
• Identity: 118/281 - (41%)
• Similarity: 168/281 - (59%)
• Gaps: 47/281 - (16%)

  Fly   210 TFDDVISLV--KKSQKIIVLTGAGVSVSCGIPDFRST-NGIYARLAHDFPDLPDPQAMFDINYFK 271
            |.:|:...:  :|.::|:|:.|||:|...|||||||. :|:|..|..  .:||..:|:|:||||.
Zfish    87 TLEDIAEKIRERKFKRIVVMAGAGISTPSGIPDFRSPGSGLYDNLQQ--YNLPYAEAIFEINYFH 149

  Fly   272 RDPRPFYKFAREIYPGEFQPSPCHRFIKMLETKGKLLRNYTQNIDTLERVAGI--QRVIECHGSF 334
            .:|.||:..|:|:|||.:||:..|.||:||..|.:|||.||||||.|||:|||  :.::|.||:|
Zfish   150 HNPNPFFALAKELYPGNYQPNLTHYFIRMLHDKEQLLRMYTQNIDGLERMAGIPPKMLVEAHGTF 214

  Fly   335 STASCTKCRFKCNADALRADIFAQRIPVCPQCQPNKEQSVDASVAVTEEELRQLVENGIMKPDIV 399
            :||:||.||.....:.||.||.|..:|.||.|:                        ||:|||||
Zfish   215 ATATCTVCRRDYKGEELRDDIMAGTVPKCPTCK------------------------GIIKPDIV 255

  Fly   400 FFGEGLPDEYHTVMATDKDVCDLLIVIGSSLKVRPVAHIPSSIPATVPQILINRE---------Q 455
            ||||.||..:.|.: ||..:.|||||:|:||:|.|.|.:..::..:||::||||:         |
Zfish   256 FFGEELPQHFFTYL-TDFPIADLLIVMGTSLEVEPFASLAGAVRGSVPRLLINRDLVGPFASGSQ 319

  Fly   456 LHHLKFDVELLGDSDVIINQI 476
            .|   .||..|||   ::|.:
Zfish   320 RH---TDVAELGD---VVNGV 334

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sirt1	NP_477351.1	SIRT1	222..476	CDD:238699	115/265 (43%)
sirt3	XP_009301762.1	SIRT1	101..337	CDD:238699	115/267 (43%)