DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sirt1 and SIRT6

DIOPT Version :10

Sequence 1:NP_477351.1 Gene:Sirt1 / 34708 FlyBaseID:FBgn0024291 Length:823 Species:Drosophila melanogaster
Sequence 2:NP_057623.2 Gene:SIRT6 / 51548 HGNCID:14934 Length:355 Species:Homo sapiens


Alignment Length:109 Identity:23/109 - (21%)
Similarity:33/109 - (30%) Gaps:50/109 - (45%)


- Green bases have known domain annotations that are detailed below.


  Fly    31 DVLLAYLCSRPGTTLS--IKD--ISQEMAIN--------------SYDIV-------STLQALGM 70
            |:.||.|....|....  .:|  |.||:.::              ::|:|       .||..||.
Human   101 DIRLAKLYGADGLVFGALTEDGHIDQELCLSLVALCRPLPVTFHRAFDMVQDPMAALETLLTLGF 165

  Fly    71 MKYWKGKHIILKKLDVLDEYEERVKRRGNMPKIDQSCLKWTPFV 114
                                 |||...|    .|.|.|:..|.:
Human   166 ---------------------ERVLTSG----CDSSALEGLPLI 184

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sirt1NP_477351.1 SIRT1 222..476 CDD:238699
SIRT6NP_057623.2 SIRT7 45..257 CDD:238701 23/109 (21%)
Disordered. /evidence=ECO:0000269|PubMed:33067423 284..355
Blue background indicates that the domain is not in the aligned region.

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