Protein Alignment Sirt1 and sirt2

DIOPT Version :10

• Sequence 1: NP_477351.1
• Gene: Sirt1 / 34708
• FlyBaseID: FBgn0024291
• Length: 823
• Species: Drosophila melanogaster
• Sequence 2: NP_955890.1
• Gene: sirt2 / 322309
• ZFINID: ZDB-GENE-030131-1028
• Length: 379
• Species: Danio rerio
• Alignment Length: 457
• Identity: 155/457 - (33%)
• Similarity: 221/457 - (48%)
• Gaps: 113/457 - (24%)

  Fly   112 EEEDDEEEEEDDEEGITGTSNEDEDSSSNCSSSVEPDWKLRWLQREFYTGRVPRQVIASIMPHFA 176
            ||.....|||.|..|:.|.|::..| ..:.|...|.|: ||.|                    |:
Zfish     3 EEVSKRVEEEADTPGLEGQSDDSSD-EGDASGDTEMDF-LRSL--------------------FS 45

  Fly   177 TGLAGDTDDSVLWDYLAHLLNEPKRRNKLASVNTFDDVIS--LVKKSQKIIVLTGAGVSVSCGIP 239
            ..|.....|.|| |.|                 |.|.|..  |..|.:.||.:.|||:|.|.|||
Zfish    46 RTLGLSPGDKVL-DEL-----------------TLDSVARYILSGKCKNIICMVGAGISTSAGIP 92

  Fly   240 DFRST-NGIYARLAHDFPDLPDPQAMFDINYFKRDPRPFYKFAREIYPGEFQPSPCHRFIKMLET 303
            ||||. .|:||.|..  .:||.|:|:|.|:|||:.|.||:..|||:|||:|:|:..|.|||||:.
Zfish    93 DFRSPGTGLYANLQK--YNLPYPEAIFQIDYFKKHPEPFFALARELYPGQFKPTVYHYFIKMLKD 155

  Fly   304 KGKLLRNYTQNIDTLERVAGI--QRVIECHGSFSTASCTK--CRFKCNADALRADIFAQRIPVCP 364
            ||.|.|.|:|||||||||||:  :.:||.||:|.|:.|..  ||.:.:.|.::..||::.||.|.
Zfish   156 KGLLRRCYSQNIDTLERVAGLEGEDLIEAHGTFHTSHCVSFLCRKEYSMDWMKNQIFSEEIPKCD 220

  Fly   365 QCQPNKEQSVDASVAVTEEELRQLVENGIMKPDIVFFGEGLPDEYHTVMATDKDVCDLLIVIGSS 429
            .|                        ..::|||||||||.||..:.|.|..|...|||||::|:|
Zfish   221 SC------------------------GSLVKPDIVFFGESLPSRFFTSMKADFPQCDLLIIMGTS 261

  Fly   430 LKVRPVAHIPSSIPATVPQILINREQLHHLKFDVELLG-------DSDVIINQICHRLSDNDDC- 486
            |:|:|.|.:.|.:....|::|||.|:....:|.:.|..       |||.....:.|..:.:|.|
Zfish   262 LQVQPFASLVSRVSNRCPRLLINMEKTGQSEFGMGLFSFGGGMDFDSDKAYRDVAHLSTCDDGCM 326

  Fly   487 -------WRQLCCDESVLTESKELMPPEHSNHHLHHHLLHHRHCSSESERQSQLDTDTQSIKSNS 544
                   |::         |.:|::..||:       |:.    |.::::     ||.::.:|:.
Zfish   327 TLAELLGWKK---------ELEEMVKREHA-------LID----SKDAKK-----TDKEASQSSK 366

  Fly   545 SA 546
            ||
Zfish   367 SA 368

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sirt1	NP_477351.1	SIRT1	222..476	CDD:238699	112/265 (42%)
sirt2	NP_955890.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..32		10/29 (34%)
		SIRT1	75..328	CDD:238699	115/278 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	349..379		6/29 (21%)