Protein Alignment Sirt1 and hst2

DIOPT Version :10

• Sequence 1: NP_477351.1
• Gene: Sirt1 / 34708
• FlyBaseID: FBgn0024291
• Length: 823
• Species: Drosophila melanogaster
• Sequence 2: NP_588147.1
• Gene: hst2 / 2538868
• PomBaseID: SPCC132.02
• Length: 332
• Species: Schizosaccharomyces pombe
• Alignment Length: 314
• Identity: 117/314 - (37%)
• Similarity: 176/314 - (56%)
• Gaps: 37/314 - (11%)

  Fly   202 RNKLASVNT---FDDVISLVK--KSQKIIVLTGAGVSVSCGIPDFRS-TNGIYARLAHDFPDLPD 260
            :|.:..|::   .:.|.||:|  |.:||.|:.|||:|.:.||||||| ..|||..|...  :||.
pombe     3 KNTVKHVDSSKHLEKVASLIKEGKVKKICVMVGAGISTAAGIPDFRSPETGIYNNLQRF--NLPY 65

  Fly   261 PQAMFDINYFKRDPRPFYKFAREIYPGEFQPSPCHRFIKMLETKGKLLRNYTQNIDTLERVAGI- 324
            .:|:||::||:::|||||:.|.|:.|.:::|:..|.||::|..|..|.:.||||||||||:||:
pombe    66 AEAVFDLSYFRKNPRPFYELAHELMPEKYRPTYTHYFIRLLHDKRLLQKCYTQNIDTLERLAGVP 130

  Fly   325 -QRVIECHGSFSTASCTKCRFKCNADALRADIFAQRIPVCPQCQPNKEQSVDASVAVTEEELRQL 388
             :.:||.||||..:.|.:|......:.:||.|..:::|.|..|:
pombe   131 DKALIEAHGSFQYSRCIECYEMAETEYVRACIMQKQVPKCNSCK--------------------- 174

  Fly   389 VENGIMKPDIVFFGEGLPDEYHTVMATDKDVCDLLIVIGSSLKVRPVAHIPSSIPATVPQILINR 453
               |::||.|||:|||||..:...|..|..|||:.:|||:||.|.|.|.:|..:|....::||||
pombe   175 ---GLIKPMIVFYGEGLPMRFFEHMEKDTKVCDMALVIGTSLLVHPFADLPEIVPNKCQRVLINR 236

  Fly   454 E---QLHHLKFDVELLGDSDVIINQICHRLSDNDDCWRQLCCDESVLTESKELM 504
            |   .....|.|:.:|||.|..:..:|..|..:|:..:.:......|||...|:
pombe   237 EPAGDFGERKKDIMILGDCDSQVRALCKLLGWSDELEKLIDTSVETLTEEISLL 290

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sirt1	NP_477351.1	SIRT1	222..476	CDD:238699	103/259 (40%)
hst2	NP_588147.1	SIRT1	28..262	CDD:238699	103/259 (40%)