Protein Alignment Sirt1 and SIRT3

DIOPT Version :10

• Sequence 1: NP_477351.1
• Gene: Sirt1 / 34708
• FlyBaseID: FBgn0024291
• Length: 823
• Species: Drosophila melanogaster
• Sequence 2: NP_001357239.1
• Gene: SIRT3 / 23410
• HGNCID: 14931
• Length: 417
• Species: Homo sapiens
• Alignment Length: 381
• Identity: 128/381 - (33%)
• Similarity: 196/381 - (51%)
• Gaps: 79/381 - (20%)

  Fly   161 GRVPRQVIASIMPHFATGLAGDTDDSVLWDYLAHLLNEPKRRNKLASVNTFDDVISLV--KKSQK 223
            ||  |.:..|:......|..|.:|                 :.||    :..||..|:  :..|:
Human    98 GR--RSISFSVGASSVVGSGGSSD-----------------KGKL----SLQDVAELIRARACQR 139

  Fly   224 IIVLTGAGVSVSCGIPDFRST-NGIYARLAHDFPDLPDPQAMFDINYFKRDPRPFYKFAREIYPG 287
            ::|:.|||:|...|||||||. :|:|:.|..  .|||.|:|:|::.:|..:|:||:..|:|:|||
Human   140 VVVMVGAGISTPSGIPDFRSPGSGLYSNLQQ--YDLPYPEAIFELPFFFHNPKPFFTLAKELYPG 202

  Fly   288 EFQPSPCHRFIKMLETKGKLLRNYTQNIDTLERVAGI--QRVIECHGSFSTASCTKCRFKCNADA 350
            .::|:..|.|:::|..||.|||.||||||.||||:||  .:::|.||:|::|:||.|:.....:.
Human   203 NYKPNVTHYFLRLLHDKGLLLRLYTQNIDGLERVSGIPASKLVEAHGTFASATCTVCQRPFPGED 267

  Fly   351 LRADIFAQRIPVCPQCQPNKEQSVDASVAVTEEELRQLVENGIMKPDIVFFGEGLPDEY--HTVM 413
            :|||:.|.|:|.||.|                        .|::|||||||||.||..:  |.|
Human   268 IRADVMADRVPRCPVC------------------------TGVVKPDIVFFGEPLPQRFLLHVV- 307

  Fly   414 ATDKDVCDLLIVIGSSLKVRPVAHIPSSIPATVPQILINREQL-----HHLKFDVELLGDSDVII 473
              |..:.|||:::|:||:|.|.|.:..::.::||::||||:.:     |....||..|||....:
Human   308 --DFPMADLLLILGTSLEVEPFASLTEAVRSSVPRLLINRDLVGPLAWHPRSRDVAQLGDVVHGV 370

  Fly   474 NQICHRLSDNDDCWRQLCCDESVLTESKELMPPEHSNHHLHHHLLHHRHCSSESER 529
            ..:...|.     |.:...| .|..|:.::...|..         |.|.|.|...|
Human   371 ESLVELLG-----WTEEMRD-LVQRETGKVQTAEED---------HPRGCPSHCSR 411

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sirt1	NP_477351.1	SIRT1	222..476	CDD:238699	105/263 (40%)
SIRT3	NP_001357239.1	SIRT1	138..373	CDD:238699	105/263 (40%)