Protein Alignment Sirt1 and SIRT5

DIOPT Version :10

• Sequence 1: NP_477351.1
• Gene: Sirt1 / 34708
• FlyBaseID: FBgn0024291
• Length: 823
• Species: Drosophila melanogaster
• Sequence 2: NP_036373.1
• Gene: SIRT5 / 23408
• HGNCID: 14933
• Length: 310
• Species: Homo sapiens
• Alignment Length: 256
• Identity: 80/256 - (31%)
• Similarity: 123/256 - (48%)
• Gaps: 48/256 - (18%)

  Fly   220 KSQKIIVLTGAGVSVSCGIPDFRSTNGIYARLAHDFPDLPDPQAMFDINYFKRDPR---PFYKFA 281
            |::.|::::|||||...|:|.||...|.:.:  ....||..|.|      |..:|.   .||.:.
Human    49 KAKHIVIISGAGVSAESGVPTFRGAGGYWRK--WQAQDLATPLA------FAHNPSRVWEFYHYR 105

  Fly   282 REIYPGEFQPSPCHRFIKMLETK----GKLLRNYTQNIDTLERVAGIQRVIECHGSFSTASCTKC 342
            ||:. |..:|:..||.|...||:    |:.:...|||||.|.|.||.:.::|.|||.....||.|
Human   106 REVM-GSKEPNAGHRAIAECETRLGKQGRRVVVITQNIDELHRKAGTKNLLEIHGSLFKTRCTSC 169

  Fly   343 RFKCNADALRADIFAQ--RIPVCPQC------QPNKEQSVDASVAVTEEELRQLVE---NGIMKP 396
                       .:.|:  :.|:||..      :|..:   |||:.|  |:|.:..|   .|:::|
Human   170 -----------GVVAENYKSPICPALSGKGAPEPGTQ---DASIPV--EKLPRCEEAGCGGLLRP 218

  Fly   397 DIVFFGEGLPDEYHTVMATDKDV--CDLLIVIGSSLKVRPVAHIPSSIPAT-VPQILINRE 454
            .:|:|||.|  :...:...|:::  |||.:|:|:|..|.|.|.....:.|. ||....|.|
Human   219 HVVWFGENL--DPAILEEVDRELAHCDLCLVVGTSSVVYPAAMFAPQVAARGVPVAEFNTE 277

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sirt1	NP_477351.1	SIRT1	222..476	CDD:238699	79/254 (31%)
SIRT5	NP_036373.1	SIRT5_Af1_CobB	51..301	CDD:238703	79/254 (31%)