Protein Alignment Sirt1 and sir-2.1

DIOPT Version :10

• Sequence 1: NP_477351.1
• Gene: Sirt1 / 34708
• FlyBaseID: FBgn0024291
• Length: 823
• Species: Drosophila melanogaster
• Sequence 2: NP_001255484.1
• Gene: sir-2.1 / 177924
• WormBaseID: WBGene00004800
• Length: 607
• Species: Caenorhabditis elegans
• Alignment Length: 735
• Identity: 238/735 - (32%)
• Similarity: 325/735 - (44%)
• Gaps: 180/735 - (24%)

  Fly    64 SELAGKANGEIKTKTLAAREEQEIGANLEHKTKNPTKSMGEDEDDEEEEEEDDEEEEEDDEEGIT 128
            ||:| ..:||::..|   .|..|||:  .|.|:         |.|..:..|.:.:......|..|
 Worm     9 SEVA-VTHGEVQEIT---EENPEIGS--MHITQ---------ETDISDAPETNTDSSRQRTESTT 58

  Fly   129 GTSNEDEDSSSNCSSSVEPDWKLRWLQREFYTGRVPRQVIASIMPHFATGLAGDTDDSVLWDYLA 193
            ..|:|...::....|:      ||..||....|..|.|:|..|.|.|.........::..:..|:
 Worm    59 SVSSESWQNNDEMMSN------LRRAQRLLDDGATPLQIIQQIFPDFNASRIATMSENAHFAILS 117

  Fly   194 HLLNEPKRRNKLASVNTFDDVISLVKKSQKIIVLTGAGVSVSCGIPDFRSTNGIYARLAHDFPDL 258
            .||.....|.||.:.|:..|.:.|.|..:.|:||||||||||||||||||.:||||||..:||||
 Worm   118 DLLERAPVRQKLTNYNSLADAVELFKTKKHILVLTGAGVSVSCGIPDFRSKDGIYARLRSEFPDL 182

  Fly   259 PDPQAMFDINYFKRDPRPFYKFAREIYPGEFQPSPCHRFIKMLETKGKLLRNYTQNIDTLERVAG 323
            |||.|||||.||:.:|.|||.|||||:||:|.||..|||||.|||.|:|||||||||||||...|
 Worm   183 PDPTAMFDIRYFRENPAPFYNFAREIFPGQFVPSVSHRFIKELETSGRLLRNYTQNIDTLEHQTG 247

  Fly   324 IQRVIECHGSFSTASCTKCRFKCNADALRADIFAQRIPVCPQCQPNKEQSVDASVAVTEEELRQL 388
            |:||:|||||||..:||:|..|.:.:.:|.::.|.|:..|.:|:
 Worm   248 IKRVVECHGSFSKCTCTRCGQKYDGNEIREEVLAMRVAHCKRCE--------------------- 291

  Fly   389 VENGIMKPDIVFFGEGLPDEYHTVMATDKDVCDLLIVIGSSLKVRPVAHIPSSIPATVPQILINR 453
               |::||:||||||.|..|:|..:..||...||::||||||||||||.||..:...||||||||
 Worm   292 ---GVIKPNIVFFGEDLGREFHQHVTEDKHKVDLIVVIGSSLKVRPVALIPHCVDKNVPQILINR 353

  Fly   454 EQLHHLKFDVELLGDSDVIINQICHRLSDNDDCWRQLCCDESVLTESK---ELMPPEHSNHHLHH 515
            |.|.|...|:||||:.|.||..||..|..:   :.:|......:.|.:   :...|..:...|..
 Worm   354 ESLPHYNADIELLGNCDDIIRDICFSLGGS---FTELITSYDSIMEQQGKTKSQKPSQNKRQLIS 415

  Fly   516 HLLHHRHCSSESERQSQLDTDTQSIKSNSSADYILGSAGTCSDSGFESSTFSCGKRSTAAEAAAI 580
            .......|..|.......|..|......|.||..:.|         |.:.|.           .|
 Worm   416 QEDFLNICMKEKRNDDSSDEPTLKKPRMSVADDSMDS---------EKNNFQ-----------EI 460

  Fly   581 ERIKTDILVELNETTALSCDRLGLEGPQTTVESYRHLSIDSSKDSGIEQCDNEATPSYVRPSNLV 645
            ::.|:    |.::.|..|.|.|         :..:|                   |..:..:.::
 Worm   461 QKHKS----EDDDDTRNSDDIL---------KKIKH-------------------PRLLSITEML 493

  Fly   646 QETKTVAPSLTPIPQQRGKRQTAAERLQPGTFYSHTNNYSYVFPGAQVFWDND------------ 698
            .:.|.||.|         ..||                   |||||:..:|.:
 Worm   494 HDNKCVAIS---------AHQT-------------------VFPGAECSFDLETLKLVRDVHHET 530

  Fly   699 ----------YSDDDDE----------------EEERSHNRHSDLFGNVGHNYKDDDEDACDLN- 736
                      .|:.|.|                :|:|.:..|.||          ...|:||.:
 Worm   531 HCESSCGSSCSSNADSEANQLSRAQSLDDFVLSDEDRKNTIHLDL----------QRADSCDGDF 585

  Fly   737 AVPLSPLLPPSLEAHIVTDI 756
            ...||..:.|...:|:..::
 Worm   586 QYELSETIDPETFSHLCEEM 605

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sirt1	NP_477351.1	SIRT1	222..476	CDD:238699	144/253 (57%)
sir-2.1	NP_001255484.1	SIRT1	146..376	CDD:238699	144/253 (57%)