Protein Alignment Sirt1 and LOC1273019

DIOPT Version :10

• Sequence 1: NP_477351.1
• Gene: Sirt1 / 34708
• FlyBaseID: FBgn0024291
• Length: 823
• Species: Drosophila melanogaster
• Sequence 2: XP_311957.5
• Gene: LOC1273019 / 1273019
• VectorBaseID: AGAMI1_003031
• Length: 615
• Species: Anopheles gambiae
• Alignment Length: 643
• Identity: 164/643 - (25%)
• Similarity: 245/643 - (38%)
• Gaps: 249/643 - (38%)

  Fly    42 ASTSTEAEAEAEATATTTEPAT---------SELAGKANGEIKTKTLAAREEQEIGA--NLEHKT 95
            |:.::.|.|.|..:...||||:         |..|...||.:..:..||   ..:||  :.:|
Mosquito    44 AAAASTASAIAGVSVALTEPASDPTITPLGPSPPASIVNGAVGPEVAAA---AAVGALPDFQH-- 103

  Fly    96 KNPTKSMGEDEDDEEEEEEDDEEEEE------DDEEGI-TGTSNEDEDSSSNCSSSVEPDWKLRW 153
                  ..|.|||.|:....:....|      .|:.|. ||...|:|:.|...:
Mosquito   104 ------YDESEDDAEDPYHSESISIERIRQYLSDKLGFHTGDGFENENGSGGAA----------- 151

  Fly   154 LQREFYTGRVPRQVIASIMPHFATGLAGDTDDSVLWDYLAHLLNEPKRRNKLASVNTFDDVISLV 218
                                                           ||..|.:|: .|.|:...
Mosquito   152 -----------------------------------------------RRRVLETVD-IDGVLKHW 168

  Fly   219 KKS--QKIIVLTGAGVSVSCGIPDFRSTN-GIYARLAHDFPDLPDPQAMFDINYFKRDPRPFYKF 280
            |..  :||:.:.|||:|.|.|||||||.| |:|..|..  .:||.|||:|::.|..::|:||:..
Mosquito   169 KSGGFKKIVTMVGAGISTSAGIPDFRSPNTGLYNNLMK--YNLPYPQAIFELEYLHQNPKPFFTL 231

  Fly   281 AREIYPGEFQPSPCHRFIKMLETKGKLLRNYTQNIDTLERVAGI--QRVIECHGSFSTASCTKCR 343
            |:|:|||.|:|:|.|.|:::||.||.|:|:||||||||||:|||  .:::|.||:|.|..|.:|:
Mosquito   232 AKELYPGTFKPTPSHYFVRLLEQKGLLVRHYTQNIDTLERIAGIPEDKIVEAHGTFYTNHCLECK 296

  Fly   344 FKCNADALRADIFAQRIPVCPQCQPNKEQSVDASVAVTEEELRQLVENGIMKPDIVFFGEGLPDE 408
            ...:.:.::..|||..:|.|| |                        .|::||||||||||||:.
Mosquito   297 IAYSLEFVKEKIFADEVPTCP-C------------------------GGVIKPDIVFFGEGLPER 336

  Fly   409 YHTVMATDKDVCDLLIVIGSSLKVRPVAHIPSSIPATVPQILINREQ------------------ 455
            :|.:...|...|||||::|:||.|:|.|.:...:.....::||||::
Mosquito   337 FHMLPHQDFAECDLLIIMGTSLTVQPFASLVEYVNDDCVRLLINRDKVGCNSFGFLRSMVFGEGL 401

  Fly   456 ----------------------------------------------------------------- 455
                                                                             
Mosquito   402 CFDLPGNRRDVAWTGNCDDGCFFLADQLGWGDELRKLVETEHAKIKPIRPIATNAIAVPDGTVVD 466

  Fly   456 ------LHH-----LKFDVELLGDSDVIINQICHRLS---------------DNDDCWRQLCC-- 492
                  :||     |..|.|.|...|...|.:...||               |::...:.:..
Mosquito   467 MEPTTDIHHTDDHCLVDDAECLLPEDEHFNDVADGLSGQGGGVVVCAGAGVDDSEGSVQAMATDP 531

  Fly   493 ----DESVLTESKELMPPEHSNHH--------------LHHHLLHHRHCSSESERQSQ 532
                ||..:.|......|.|.:||              ||||..||:|...:.::|.:
Mosquito   532 HHDHDEPTVLEPHHPNHPHHHHHHHTTEPNSHHHHHAQLHHHHAHHQHHPEQQQQQHE 589

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sirt1	NP_477351.1	SIRT1	222..476	CDD:238699	109/350 (31%)
LOC1273019	XP_311957.5	SIRT1	174..422	CDD:238699	101/274 (37%)