Protein Alignment Pk34A and GSK3B

DIOPT Version :10

• Sequence 1: NP_609603.1
• Gene: Pk34A / 34705
• FlyBaseID: FBgn0028410
• Length: 392
• Species: Drosophila melanogaster
• Sequence 2: NP_002084.2
• Gene: GSK3B / 2932
• HGNCID: 4617
• Length: 433
• Species: Homo sapiens
• Alignment Length: 367
• Identity: 141/367 - (38%)
• Similarity: 201/367 - (54%)
• Gaps: 27/367 - (7%)

  Fly    25 SVISTYAVGRLCSEPALVRIEVKDLIGSGSFGRVYQAHVNESEEIVAVKQTLYNPKLSQGEAEIM 89
            :|::|...|.  ..|..|......:||:||||.||||.:.:|.|:||:|:.|.:.:....|.:||
Human    39 TVVATPGQGP--DRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIM 101

  Fly    90 GQLKDHNNIVRL--IMHSSVSLGFPSVD-YVLLVMEYMPMTLLDYINYHLTVLQPAERLINVRIL 151
            .:| ||.|||||  ..:||   |....: |:.||::|:|.|:.....::....|... :|.|::.
Human   102 RKL-DHCNIVRLRYFFYSS---GEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLP-VIYVKLY 161

  Fly   152 SYQMFRGLGYLHLLGISHRDVKPENLLIDNQKMVLKLSDFGSAKLLVPQEPSISYICSRLYRAPE 216
            .||:||.|.|:|..||.|||:||:|||:|....||||.||||||.||..||::||||||.|||||
Human   162 MYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPE 226

  Fly   217 LFAGYELYSCAVDIWSAGCVLAELLKGYPLFSSHKHDRKQLRLIVNMLGTDGLERAPEILSKCGN 281
            |..|...|:.::|:|||||||||||.|.|:|.... ...||..|:.:|||...|:..|:......
Human   227 LIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDS-GVDQLVEIIKVLGTPTREQIREMNPNYTE 290

  Fly   282 SLHPRTTRPSWN-------------YLLNTAVPQDLCGLLNSCFIYEAAARISPMMACSHGSYDE 333
            ...|:.....|.             .:.....|.:...|.:....|...||::|:.||:|..:||
Human   291 FKFPQIKAHPWTKDSSGTGHFTSGVRVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDE 355

  Fly   334 LRIMDAMALPMPNGNPLPPLFDFNSLEMGTDPKLWVNLLPIH 375
            ||..:   :.:|||...|.||:|.:.|:.::|.|...|:|.|
Human   356 LRDPN---VKLPNGRDTPALFNFTTQELSSNPPLATILIPPH 394

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pk34A	NP_609603.1	STKc_GSK3	39..334	CDD:271039	122/310 (39%)
GSK3B	NP_002084.2	STKc_GSK3	51..356	CDD:271039	122/310 (39%)