Protein Alignment nub and POU5F1

DIOPT Version :10

• Sequence 1: NP_001097153.1
• Gene: nub / 34669
• FlyBaseID: FBgn0085424
• Length: 961
• Species: Drosophila melanogaster
• Sequence 2: NP_002692.2
• Gene: POU5F1 / 5460
• HGNCID: 9221
• Length: 360
• Species: Homo sapiens
• Alignment Length: 220
• Identity: 104/220 - (47%)
• Similarity: 133/220 - (60%)
• Gaps: 20/220 - (9%)

  Fly   731 PSSAASLKLSGMLTPSTPTS----GTQMSQGTTTPQPKTVASAAA--ARAAGEPSPEETTDL--- 786
            |.....|...|.|..|.|..    |.:.:....:|:|.||...|.  .:...|.:|||:.|:
Human    78 PQVGVGLVPQGGLETSQPEGEAGVGVESNSDGASPEPCTVTPGAVKLEKEKLEQNPEESQDIKAL 142

  Fly   787 -EELEQFAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLQKW 850
             :|||||||..||:||.||:||.||||.:|.|:|..||||||.|||||.|||||||||:||||||
Human   143 QKELEQFAKLLKQKRITLGYTQADVGLTLGVLFGKVFSQTTICRFEALQLSFKNMCKLRPLLQKW 207

  Fly   851 LDDADRTIQATGGVFDPAALQATVSTPEIIGRRRKKRTSIETTIRGALEKAFLANQKPTSEEITQ 915
            :::||..          ..||.......::..|::||||||..:||.||..||...|||.::|:.
Human   208 VEEADNN----------ENLQEICKAETLVQARKRKRTSIENRVRGNLENLFLQCPKPTLQQISH 262

  Fly   916 LADRLSMEKEVVRVWFCNRRQKEKR 940
            :|.:|.:||:||||||||||||.||
Human   263 IAQQLGLEKDVVRVWFCNRRQKGKR 287

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nub	NP_001097153.1	POU	791..855	CDD:197673	45/63 (71%)
		Homeodomain	884..940	CDD:459649	32/55 (58%)
POU5F1	NP_002692.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..52
		9aaTAD. /evidence=ECO:0000269|PubMed:34342803	4..12
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	88..114		6/25 (24%)
		POU	138..212	CDD:197673	49/73 (67%)
		DNA-binding. /evidence=ECO:0000250|UniProtKB:P20263	180..186		5/5 (100%)
		DNA-binding. /evidence=ECO:0000250|UniProtKB:P20263	193..196		2/2 (100%)
		Homeodomain	231..287	CDD:459649	32/55 (58%)