Protein Alignment Trm1 and Trmt1

DIOPT Version :10

• Sequence 1: NP_609566.1
• Gene: Trm1 / 34656
• FlyBaseID: FBgn0032430
• Length: 578
• Species: Drosophila melanogaster
• Sequence 2: NP_932137.2
• Gene: Trmt1 / 212528
• MGIID: 1289155
• Length: 663
• Species: Mus musculus
• Alignment Length: 573
• Identity: 270/573 - (47%)
• Similarity: 350/573 - (61%)
• Gaps: 49/573 - (8%)

  Fly     5 EEKPQIIAENPNENV--IRERNAEIV--SGGNVFYNPVQEFNRDLSIAALNVY-RQRL------T 58
            ||:|      |.:.|  :.|..|:||  |...|||||||||||||:.|.:..: |..|      .
Mouse    47 EERP------PADPVATVTEGAAKIVFPSANEVFYNPVQEFNRDLTCAVITEFARIHLGAKGIQI 105

  Fly    59 KERSEKALKKQRKKVKEQEDE----KTTPVPED-PPVYEAGTRYEDGLRILEALAATGLRSIRYA 118
            |...||..:|....:.:||:|    .....|.| |.....|...|:|||:||.|||:||||||:|
Mouse   106 KVPGEKDSEKIAVDLSDQEEETAGKNENLAPGDWPRTAAVGEICEEGLRVLEGLAASGLRSIRFA 170

  Fly   119 QEIAGVRQIVANDLSRQAVASINTNIRHNKVEELIEPSHSDAMTLMYLSTQPEKRFDAVDLDPYG 183
            .|:.|::.:||||.|.:||..::.|:..|.|..|::|:.:||..|||...:..:|||.:||||||
Mouse   171 LEVPGLQSVVANDASARAVELMHRNVELNGVAHLVQPNQADARMLMYQHQKAPERFDVIDLDPYG 235

  Fly   184 CPNRFLDGAMQCLVDGGLLLVTATDMAVLAGNAPEACYVKYGSVPLRMKCCHEMALRILLHCIES 248
            .|..|||.|:|.:.|||||.||.|||||||||:.|.||.|||::.|:.:.||||||||:||.::.
Mouse   236 SPAPFLDAAVQAVSDGGLLCVTCTDMAVLAGNSGETCYSKYGAMALKSRACHEMALRIVLHSLDL 300

  Fly   249 HANRYGKYIEPLLSISADFYIRIFVRVYVGQAQCKLSMSKQSWIYQCTGCETFTLQPLGITKPNP 313
            |||.|.:||.||||||||||||:||||:.|||:.|.|.|||:.::||.||..|.||.||     .
Mouse   301 HANCYQRYIVPLLSISADFYIRVFVRVFTGQAKVKSSASKQALVFQCVGCGAFYLQRLG-----K 360

  Fly   314 TAGNP-QQLKFGIPTGPAVNSQCEHCGHRHHLGGPIWSAPIHNPEFVQDLLTAVQETTLQSLGTQ 377
            .:|:| .::||....||.|..:|||||.||.||||:|:.|||:.:||..:|.|| .|......|.
Mouse   361 ASGDPGGRIKFSAACGPPVTPECEHCGQRHQLGGPMWAEPIHDLDFVGRVLDAV-TTNPGRFHTS 424

  Fly   378 RRIVGVLSMVQEELQDVPLYYTPDKLCCVLKLEIVPMLKFRSAILHAGYRVSYSHASKNSLKTNA 442
            .||.||||:|.|||.|||||||.|:|...:......:|:.|||:||||:|||.|||.||::||:|
Mouse   425 MRIQGVLSVVTEELPDVPLYYTLDQLSSTIHCNTPRLLQLRSALLHAGFRVSLSHACKNAVKTDA 489

  Fly   443 PPAVLWDILRSWSKRHPVNPERMIPGSPLAAILSKECTAVYEFDELHPEANPKSRKSALSRFQEN 507
            ||..||||:|.|.|..||..||:...||...||:.|......|: :..:|||.||:..|.|||.|
Mouse   490 PPEALWDIMRCWEKECPVKRERLSESSPAFRILAVEPRLKANFN-IREDANPSSRQRGLKRFQAN 553

  Fly   508 PTPHWGPGTRA--------TIMIGDNKLPKSYRNQNKKQRHKASEQQAEDDQQ 552
            |..:|||..||        ..:.|..:|     .|||:      ::.|||..|
Mouse   554 PEANWGPRPRARPGGKAASEDLAGRRRL-----LQNKR------KEPAEDPAQ 595

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Trm1	NP_609566.1	AdoMet_MTases	17..452	CDD:473071	228/451 (51%)
Trmt1	NP_932137.2	TRM	65..499	CDD:396545	225/439 (51%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	534..574		16/39 (41%)
		Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:Q9NXH9	540..572		14/31 (45%)
		ZnF_C3H1	599..625	CDD:214632
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	632..663