DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pkd2 and PKD1

DIOPT Version :10

Sequence 1:NP_609561.2 Gene:Pkd2 / 34651 FlyBaseID:FBgn0041195 Length:924 Species:Drosophila melanogaster
Sequence 2:XP_047290164.1 Gene:PKD1 / 5310 HGNCID:9008 Length:4348 Species:Homo sapiens


Alignment Length:547 Identity:116/547 - (21%)
Similarity:200/547 - (36%) Gaps:115/547 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   435 LGPPRLRQIRVRKESCYVNDAFIRYFNTCYAA-------YSSGAEDRKPMHKGS-------PFRT 485
            ||||||||:|: :|:.|.:....| .:||.||       |..|.|.   .|.||       |   
Human  3789 LGPPRLRQVRL-QEALYPDPPGPR-VHTCSAAGGFSTSDYDVGWES---PHNGSGTWAYSAP--- 3845

  Fly   486 MHDLDSTPIWTVLAFYRTGGYT----VNLDYDKDRNVKIINDLKDIHWLDRGSRLCLVEFNLFNE 546
              ||.....|...|.|.:|||.    ::|:..:||    :..|:..:|||..||...:|...::.
Human  3846 --DLLGAWSWGSCAVYDSGGYVQELGLSLEESRDR----LRFLQLHNWLDNRSRAVFLELTRYSP 3904

  Fly   547 NTDIFQSIKLIAEIPPTGGVIPQAHLQTVKMYSFFTDRSM-LMTVIYIFWYIMVIYYTIYEITEI 610
            ...:..::.|..|.|..|..:....::...:.......|: |:|.:.:.  :..:::.:.|....
Human  3905 AVGLHAAVTLRLEFPAAGRALAALSVRPFALRRLSAGLSLPLLTSVCLL--LFAVHFAVAEARTW 3967

  Fly   611 RKSGIKIYFCSMLNILDCAILLGCYLALVYNIWHSFKVMSLTA-----------RAHSDVT---- 660
            .:.                   |.:..|....|..:.:::|||           .|....|    
Human  3968 HRE-------------------GRWRVLRLGAWARWLLVALTAATALVRLAQLGAADRQWTRFVR 4013

  Fly   661 -----YQSLDVLCFWNIIYVDMMAILAFLVWIKIFKFISFNKTLVQFTTTLKRCSKDLAGFSLMF 720
                 :.|.|.:...:.....:.|.|.||:.:|..:.:.|.:....|..||.|...:|.|.:|..
Human  4014 GRPRRFTSFDQVAQLSSAARGLAASLLFLLLVKAAQQLRFVRQWSVFGKTLCRALPELLGVTLGL 4078

  Fly   721 GIVFLAYAQLGLLLFGTKHPDFRNFITSILTMIRMIL----GDFQYNLIEQANRVLGPIYFLTYI 781
            .::.:|||||.:||..       :.:.|:.::.:.:|    |.....|....:..|.|:..:...
Human  4079 VVLGVAYAQLAILLVS-------SCVDSLWSVAQALLVLCPGTGLSTLCPAESWHLSPLLCVGLW 4136

  Fly   782 LLVFFILLNMFLAIIMETYNTVKGEITQGRSHLGSY--IYRKLSGMLYWITHCGRKRRHH----- 839
            .|..:..|.:...|:...|:.::||:.:.......|  :...|..:..|:.....|...|     
Human  4137 ALRLWGALRLGAVILRWRYHALRGELYRPAWEPQDYEMVELFLRRLRLWMGLSKVKEFRHKVRFE 4201

  Fly   840 -----PQASETEDKDAEHDV---GAAHDETHEIRKNMTPAEQQYFKDIPQGENQDMVRLNNRV-- 894
                 |..|....| ...||   .|..|.:|.    .|.:.|.      .|.:..:.||..|.  
Human  4202 GMEPLPSRSSRGSK-VSPDVPPPSAGSDASHP----STSSSQL------DGLSVSLGRLGTRCEP 4255

  Fly   895 --GLLEEILEKLINNMDDILKRVEKDY 919
              ..|:.:.|.|:...|.:.:..|..|
Human  4256 EPSRLQAVFEALLTQFDRLNQATEDVY 4282

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pkd2NP_609561.2 DUF5585 <29..272 CDD:465521
Polycystin_dom 404..578 CDD:466668 45/160 (28%)
PKD_channel 579..803 CDD:462341 44/248 (18%)
PKD1XP_047290164.1 PPP1R42 <54..127 CDD:455733
leucine-rich repeat 70..92 CDD:275378
leucine-rich repeat 93..116 CDD:275378
PCC 97..2773 CDD:188093
leucine-rich repeat 117..129 CDD:275378
GPS 3056..3105 CDD:470616
PLAT_polycystin 3163..3282 CDD:238850
Polycystin_dom 3758..3936 CDD:466668 45/160 (28%)
PKD_channel 3937..4158 CDD:462341 44/248 (18%)
Blue background indicates that the domain is not in the aligned region.

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